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In this study, the fibers of invasive species
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This research was aimed to optimize the synthesis of copper oxide (CuO) nanoparticles with the highest antifungalproperties against Candida albicans as an oral fungal pathogen. To this end, nine experiments involving differentsynthesis conditions were designed using the Taguchi method and the copper oxide nanoparticles synthesized bycoprecipitation method. The antifungal activity of synthesized nanoparticles against C. albicans was evaluatedusing the colony forming unit and disk diffusion methods. According to the results, the synthesized copper oxidenanoparticles under the five experimental conditions (CuCl2 0.1 M, NaOH 0.1 M, and a 75 minutes stirring time)showed the highest antifungal activity against C. albicans (71.72%). The optimization results demonstrated thatall three studied factors were effective in improving the antifungal activity of copper oxide nanoparticles and theantifungal activity in the proposed conditions can be improved by 77.85%. The synthesis of nanoparticles in optimalconditions confirmed the improved antifungal activity of the nanoparticles. The results of this study proved that CuOnanoparticles have a potential ability as an antifungal agent against oral fungal pathogens of C. albicans.
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Gold nanoclusters (AuNCs) are gold atom aggregates less than 2 nm (excluding the ligand shell) or 150 atoms. It has been widely studied due to its small size effect, fluorescence property, and catalytic activity. In this review, research progress in the preparation of gold nanoclusters containing accurate atom numbers using biomolecules and chemically synthesized molecules as ligands have been summarized. The factors that affect the preparation of gold nanoclusters have been discussed. The applications of AuNCs having accurate atomic numbers in the fields of analyte assay, catalysis, bioimaging, and drug delivery have been introduced. This review provides references to the further researches on the preparation technology and biomedical applications of AuNCs.
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Raman imaging yields high specificity and sensitivity when compared to other imaging modalities, mainly due to its fingerprint signature. However, intrinsic Raman signals are weak, thus limiting medical applications of Raman imaging. By adsorbing Raman molecules onto specific nanostructures such as noble metals, Raman signals can be significantly enhanced, termed surface-enhanced Raman scattering (SERS). Recent years have witnessed great interest in the development of SERS nanoprobes for Raman imaging. Rationally designed SERS nanoprobes have greatly enhanced Raman signals by several orders of magnitude, thus showing great potential for biomedical applications. In this review we elaborate on recent progress in design strategies with emphasis on material properties, modifying factors, and structural parameters.
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Objective Supramolecular hydrogels were the hydrogels consisting of a solid 3D network with noncovalent bonds.Its unique properties such as biocompatibility,biodegradability,free sol-gel transformation and stable drug release ability make it widely exploited for various biomedical applications.This paper mainly focused on the use of supramolecular hydrogels in all types of biomedical application such as biosensor,cell culture,tissue engineering,gene engineering and drug delivery by research literature reviews.They hope that this focus review will contribute topromote the use of supramolecular hydrogels.
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As many naturally-derived proteins,keratins have intrinsic biological activity,good biocompatibility and are biodegradable.Human hair keratins,as one type of the autogenous proteins,also have low immune rejection.Compared to other autogenous materials,human hair keratins come from a variety of sources and show attraction in field of regenerative medicine.The human hair keratins applied in neural implant materials,wound dressing,cell culture substrates,drug delivery system and soft tissue reconstructions,which are based on hydrogels,scaffolds coating,films and composite materials present huge development potential in regenerative medicine.
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Tumor markers of breast cancer are closely related to its biological behaviors and are essential for treatment strategy making. Although traditional immunohistocbemistry(IHC) is the most commonly used molecular pathological method for tumor marker detection, it can not meet the clinical requirements for quantitative and individualized treatment. With the unique photo-physical properties of quantum dots(QDs), QDs conjugated probes have been successfully used in molecular and in vivo imaging, in the study on mechanism of drug delivery and targeted therapy and especially in the detection of tumor markers in vitro and molecular targeted diagnosis of breast cancer and individualized treatment strategy making. The technique has a broad prospect in clinical application.
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Tumor markers have been of vital importance in cancer diagnosis and treatment.However,the sensitivity of tumor markers for early diagnosis is low and can not be widely used.Quantum dots are new fluorescent nanoparticles with unique photophysical and chemical properties,thus having a great potential impact on cancer pathogenesis,early diagnosis,targeted therapy,prognosis and monitoring by combining with tumor marker.The current research is focused on the detection of specific tumor markers or molecules based on tangible carriers such as cells and tissues.One of the most promising clinical applications would be to explore the potential of this highly sensitive labeling technique for the detecting and imagining of tumor markers in serum and other body fluids,where some progress has already been made recently.How to detect early cancer based solely on invisible carriers would be the next step of quantum dots bio-probes in clinical use,so as to develop a new detection technique with greater sensitivity,specificity,rapidity and convenience.