ABSTRACT
This study was carried out to evaluate the structure activity relationship and biochemical effects of some novel of anti-inflammatory triazoloquinazolines and triazinoquinazolines containing sulfacetamide moiety. Some of the newly synthesized compounds 4-17 showed good anti-inflammatory activities. Also, the median lethal doses (LD50s) of compounds 8, 10 and 17 in mice were 370, 338 and 295 mg/100g b.w., respectively. Oral administration of compounds 8, 10 and 17 to the rats at dose of 300 mg/kg.b.w. for 10 days showed non-significant changes in liver enzymes SGOT, SGPT, ALP, LDH, γ –GT, SOD and GPx and blood GSH and serum TBARs as compared with the control group. But, administration of indomethacin orally to the rats at a concentration of 600 mg/kg b.w daily for 10 days to rats showed significant increase in serum SGOT, SGPT, ALP, LDH, γ –GT and TBARs and significant decrease in blood GSH, SOD and GPx. These findings suggest that compounds 8, 10 and 17 exhibited good anti-inflammatory activity and more safe on rat liver enzymes.