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Objective To investigate the effect of Tanreqing injection on pulmonary function, blood gas index and clinical symptoms in patients with chronic obstructive pulmonary disease.Methods 90 cases of chronic obstructive pulmonary disease patients from January 2010 to December 2013 in Xinjiang Tuha Petroleum Hospital were selected as the research object.They were randomly divided into the observation group and the control group, 45 cases in each group.The control group received routine western medicine, on the basis of this, the patients in the observation group were treated with Tanreqing injection.Before treatment and 15 days after treatment, compared the two groups of patients with pulmonary function , blood gas index and the improvement of clinical symptoms.Results Before treatment, there were no significant differences between the two groups of patients with FEV1 , FVC, FEV1/FVC and other pulmonary function index, PaO2 , PaCO2 , SaO2 and other blood gas index and the scores of clinical symptoms.15 days after treatment, the two groups of patients with FEV1 , FVC, FEV1/FVC and other indicators of pulmonary function significantly increased, while its PaO2 , SaO2 levels also increased significantly, the level of PaCO2 in the two groups was decreased, and the clinical symptom scores were significantly decreased.However, the improvement rates of the observation group were significantly higher than that of the control group, the differences between the groups were statistically significant (P<0.05).Conclusion On the basis of conventional western medicine treatment, add Tanreqing injection to treat chronic obstructive pulmonary disease, can significantly improve the pulmonary function and blood gas index level, the clinical symptoms have been effectively relieved.
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Objective To investigate the effect of Tanreqing injection assisted ganciclovir on children with respiratory syncytial virus pneumonia . Methods 145 cases of RSVP pediatric patientsin from February 2013 to January 2016 in our hospital were retrospectively chosen,according to different drug regimen,they were divided into two groups,the contronl group of 71 cases with ganciclovir injection treatment and study group of 74 cases,with Tanreqing injection treatment on the basis of the contronl group.The blood gas analysis was performed on the arterial blood of the two groups before treatment and 7 and 14 days after continuous administration.The changes of blood gas indexes (pH,PaO2,PaCO2) were compared.The lung rales, wheezing, fever, cough, wheeze disappearance of time and side effects of the children were recorded.Results After 7 and 14 days of treatment, the Ph of blood gas parameters in the study group were (7.38 ±0.21) and (7.41 ±0.26), the level of PaO2 were (96.45 ±4.06) mmHg and (98.84 ± 5.27) mmHg,which were significantly higher than those of the control group (P<0.05);the level of PaCO2 in the study group were(45.02 ±4.23) mmHg and (41.26 ±3.16) mmHg, which were significantly lower than those in the contronl group (P<0.05).The rale resorption time in the study group was (4.47 ±1.06) days, the duration of wheezing subsided was (5.03 ±0.43) days, the duration of wheezing was (4.89 ±0.72) days, the duration of fever subsided was (2.46 ±0.32) days, the duration of cough was (8.41 ±1.54) days,were significantly lower than the control group(P<0.05).The adverse reaction rate in the study group was 8.11%, significantly lower than that in the control group 21.13%(P<0.05).Conclusion The combination of Tanreqing injection combined with ganciclovir has a good effect on children with RSVP , and can significantly shorten the time of clinical evidences such as wheezing, wheezing and pulmonary rales, and improve the blood gas level in children,reduce adverse reactions.
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OBJECTIVE:To observe the clinical effect of tiotropium bromide combined with salmeterol xinafoate and fluticasone propionate in the treatment of medium and severe COPD. METHODS:119 patients with medium and severe COPD were divided into control group(54 cases)and observation group(65 cases)according to admission order. Control group was treated with Salmeterol xi-nafoate and fluticasone propionate powder for inhalation 50 μg,bid;observation group was additionally given Tiotropium bromide powder for inhalation 18μg,qn. Both groups received 1 month of treatment. Lung function indexes as FEV1,FVC and IC,blood gas indexes as SaO2,PaCO2 and PaO2 and inflammatory factors as IL-8 and TNF-α,COPD assessment test(CAT)score were observed in 2 groups,and the occurrence of ADR was also observed. RESULTS:Before treatment,there was no statistical significance in above indexes between 2 groups(P>0.05). After treatment,FEV1,EVC,IC of observation group were increased significantly,SaO2 and PaO2 of observation group were increased significantly,while PaCO2,IL-8 and TNF-αlevels was decreased significantly;those index-es of observation group were significantly better than those of control group,with statistical significance(P<0.05). CAT score of 2 groups were decreased significantly compared to before treatment,and the observation group was significantly lower than control group,with statistical significance(P<0.05). No obvious ADR was found in 2 groups. CONCLUSIONS:Tiotropium bromide com-bined with salmeterol xinafoate and fluticasone propionate shows good clinical efficacy and safety in the treatment of medium and se-vere COPD.
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Objective To evaluate the effect of long term home non-invasive positive pressure ventilation (HNIPPV ) in stable severe chronic obstructive pulmonary disease (COPD) .Methods Forty-two patients with stable severe COPD after hospital dis-charge were divided into 2 groups :The observation group (conventional treatment + HNIPPV ,22 patients) and control group (con-ventional treatment ,20 patients) .Parameters before and after one year follow-up observation were compared ,which includes arterial bloods gases ,lung function test ,6-min walking distance(6MWD) ,dyspnea grade ,scoring for emotional disorders ,the hospitalization rates .Results PaCO2 ,PaO2 ,6MWD ,dyspnea grade ,scoring for emotional disorders ,the hospitalization rates improved after one year in the observation group (P < 0 .05) .There were no significance of FVC and FEV1 between the two groups after one year . There were no patients who were dead or exited with other reason after one year in the two groups .Conclusion Long term HNIP-PV could decrease exacerbations ,respiratory failure and increase life quality ,this therapy is effective and safe for patients with sta-ble severe COPD .