Dynamic effect of Huanglian Jiedu Tang on Nimodipine disposition in rat brain / 中草药

10 ng/mL). But berberine (10 ng/mL) showed no effect on the uptake of Nimodipine. Conclusion The experimental findings indicate that HLJDT pretreatment might alter the pharmacokinetic behavior of Nimodipine both in plasma and brain tissue. The change of pharmacokinetic behavior of Nimodipine in brain tissue might partly result from the effect of baicalin in HLJDT.