Buspirone Hydrochloride Sustained-release Tablets:Preparation and Release in Vitro / 中国药房

OBJECTIVE:To prepare buspiron hydrochloride sustained-release tablets and to study its release characterization in vitro and the factors affecting drug release.METHODS:Buspiron hydrochloride sustained-release tablets were prepared with hydroxypropyl methylcellulose(HPMC)as hydrophilic gel-matrix material and ethylcellulose(EC)as retarder by wet granulation.The impacts of releasing transmitters,contents of HPMC and EC,and viscosity on the drug release in vitro of the tablets were studied.RESULTS:For the prepared sustained release tablets,the 24h drug release amount was over 90%,and the drug release curve conformed to Higuchi equation.The more contents of HPMC and EC and the higher viscosity of HPMC in the tablets,the slower drug release velocity was obtained;but the viscosity of EC and the releasing transmitters had no significant impacts on the drug release velocity.CONCLUSION:With HPMC and EC as matrix materials,the 24h continuous drug release is available for buspirone hydrochloride sustained-tablets.

Eficácia e tolerabilidade do cloridrato de buspirona no tratamento dos sintomas psicossomáticos na clínica cardiológica / Efficacy and Tolerability of Buspirone Hydrochloride in the Treatment of Psychosomatic Symptoms in Cardialogy

Objetivo - Avaliar a eficácia e a segurança do cloridato de buspirona em pacientes de clínica cardiológica com manifestaçöes de ansiedade generalizada. Métodos - Cinquenta pacientes ambulatoriais de clínica cardiológica com sintomas psicossomáticos cardiovasculares foram tratados com cloridato de buspirona na dose inicial de 5mg 3 vezes ao dia, por 6 semanas. Resultado - Os resultados obtidos foram considerados bons em 76//, regulares em 18// e ineficazes em 6// dos casos. Treze pacientes (26//) relatarm pelo menos uma reaçäo adversa, os efeitos colaterais relatados foram sonolência, cefaléia, flatulência, zumbido, congestäo nasal e boca seca. Näo houve necessidade de interrupçäo do tratamento. Conclusäao - O cloridato de buspirona é uma alternativa válida no tratamento da ansiedade patológica em pacientes onde o estado de vigilância e habilidade psicomotora devem ser preservados

Purpose - To evaluate the efficacy of buspirone hydrochloride in patients of the cardiologic clinic with generalized anxiety. Méthods - Fifty out-patients with psychossomatic cardiovascular symptons in cardialogy were treated for six weeks with initial dose of 5mg of baspirone hydrochloride t.i.d. Results - The results obtained were good in 76% of the patients, foir in 18% and ineffective in 6% of the cases. Thirteen patients (26%) reported at least one adverse event, the side effects reported were: somnolence, headache, flatulence, tinnitus, nasal congestion and dry mouth. No interruption of the treatment was needed. Conclusion - Buspirone hydrochloride is a valid alternative for treating pathological anxiety in patients in which the state of alertness and good psychomotor skills must be preserved