ABSTRACT
Objective: In this study our main goal is to find out theassociation of cardiac troponin I level on admission with theangiographic severity of coronary artery disease in acuteSTEMI patients.Method: This cross-sectional observational study was done inthe NICVD, Dhaka from October 2010 to September 2011. Atotal of 100 consecutive patients were included. Studypopulations were sub-divided into two groups on the basis ofcTn I level. In group I cTn I level ≥20ng/ml and in group II cTnI level <20ng/ml. 50 patients were included in group I and 50patients were included in group II.Results: Most of the patients presented with more than 4hours chest pain which was 68% vs. 60% patients in group Iand group II respectively. Where mean heart rate was higher ingroup I than group II (83.08.4 vs. 78.210.6). It wasstatistically significant (p=0.01) in student-test. Vessel score 2and 3 together formed the main bulk of the patients (68%) ingroup I, while vessel score 0 and 1 were frequently common ingroup II (80%). In group I there was no patient with vesselscore 0, in group II 12(24%) patients had vessel score 0 (5patients had normal coronaries and 7 patients had insignificantlesions, p-value from Chi square test).Conclusion: From our study we can say that, estimation ofserum cardiac troponin I might facilitate the triage of patientswith acute myocardial infarction by clinicians and moreaggressive approach to promote myocardial reperfusion mightbe warranted in the patients with high cardiac troponin I level.
ABSTRACT
To study the effect and mechanism of Dendrobium candidum on isoproterenol-induced myocardial hypertrophy in rats, 60 healthy SD rats(30 males and 30 females) were randomly divided into 5 groups(12 in each group): normal group, model group, three D. candidum preventive administration groups(0.09, 0.18, 1.1 g·kg⁻¹). Except for the normal group, rats of other groups were injected back subcutaneously with ISO(5 mg·kg⁻¹) for 10 consecutive days. At the same time, preventive administration groups began to give different doses of the sample for 30 days and model group began to give normal saline. Left ventricular systolic pressure(LVSP) was measured in each group by common carotid artery cannulation, and the left ventricle(LW)/tibia length, heart weight index(HWI) and myocardial hydroxyproline(Hydro) content were calculated. Myocardial tissue HE staining and Masson staining were used to observe the myocardial structure and the degree of myocardial fibrosis respectively. Atrial natriuretic peptide(ANP), brain natriuretic peptide(BNP), and cardiac troponin I(cTN-I) concentration were measured by enzyme-linked immunosorbent assay(ELISA). The results showed that as compared with the normal group, the levels of ANP, BNP and cTN-I in plasma were significantly increased in ISO-induced hypertrophic rats; as compared with the model group, D. candidumcan inhibit ISO-induced ventricular pressure and ventricular hypertrophy, reduce myocardial collagen synthesis, improve myocardial fibrosis and ventricular remodeling, and significantly down-regulate ANP, BNP and cTN-I levels in plasma. This study shows that D. candidum has a protective effect on isoproterenol-induced cardiac hypertrophy.
Subject(s)
Animals , Female , Male , Rats , Cardiomegaly , Drug Therapy , Dendrobium , Chemistry , Drugs, Chinese Herbal , Pharmacology , Isoproterenol , Myocardium , Pathology , Rats, Sprague-DawleyABSTRACT
Objective To observe the value of serum cardiac troponin Ⅰ(cTn-Ⅰ) on the diagnosis of acute myocardial infarction (AMI). Methods The serum cTn-Ⅰand CK-MB of 30 elderly patients(≥65 y) and 30 middle-aged patients(