Interpretation of the key points of Cancer Incidence and Mortality in China, 2016 / 中国胸心血管外科临床杂志

@#In 2022, the National Cancer Center (NCC) of China reported the nationwide statistics of 2016 using population-based cancer registry data from all available cancer registries in China, which was mainly about the cancer incidence and mortality. Cancer remains a major health problem currently in our country and requires long term cooperation to deal with. This article provided a key point interpretation and analysis of cancer prevalence data in China, and provided an analysis of several main risk factors for cancer, which was conducive to the development of cancer prevention and control programs in different regions.

Estratégias utilizadas por enfermeiros da atenção primária na prevenção do câncer de colo do útero: revisão integrativa / Strategies used by primary care nurses in the prevention of cervical cancer: integrative review

Objetivo: identificar, na literatura científica, as estratégias utilizadas por enfermeiros da Atenção Primária para a prevenção do câncer de colo do útero. Métodos: revisão integrativa nas bases de dados EMBASE, LILACS (BVS), SCOPUS e Web of Science, entre março e abril de 2023. Após a busca, seguiu-se com leitura na íntegra dos artigos selecionados e extração dos dados para análise. A amostra final foi constituída por 5 estudos. Resultados: as principais estratégias utilizadas foram intervenções educativas, com predominância de palestras e posterior convite ou coleta de material para a realização do exame preventivo. Também foram utilizadas rodas de conversa (círculo de cultura), orientações por contato telefônico e oferta de ficha clínica auto preenchível na consulta de enfermagem. Conclusões: os estudos possibilitaram identificar estratégias positivas na prevenção do câncer de colo do útero, podendo direcionar enfermeiros a investir cada vez mais em metodologias voltadas a uma maior autonomia das mulheres

Objective: to identify, in the scientific literature, the strategies used by primary care nurses to prevent cervical cancer. Methods: An integrative review of the EMBASE, LILACS (BVS), SCOPUS, and Web of Science databases between March and April 2023. After the search, the selected articles were read in full, and the data were extracted for analysis. The final sample consisted of 5 studies. Results: the main strategies used were educational interventions, with a predominance of lectures and subsequent invitations or collection of material to carry out the preventive exam. Conversation circles (culture circles), telephone guidance, and the provision of a self-completed clinical form during the nursing consultation were also used. Conclusions: the studies made it possible to identify positive strategies for preventing cervical cancer, which could direct nurses to increasingly invest in methodologies aimed at increasing women's autonomy

A importância do enfermeiro na prevenção do câncer de mama - revisão de literatura / The importance of the nurse in the prevention of breast cancer - literature review / La importancia de la enfermera en la prevención del cáncer de mama - revisión bibliográfica

O Câncer de mama é uma doença que afeta as células mamarias, e é uma das principais causas da mortalidade em muitas mulheres, principalmente se detectado tardiamente. Objetivo: Demonstrar a importância do enfermeiro na prevenção do câncer de mama, sensibilização e conscientização das mulheres. Metodologia: Trata-se de uma revisão integrativa da literatura. Resultados e discussão: Foram selecionados 15 artigos para a amostra desta revisão, o período de publicação analisada foi de 2013 a 2023, sendo o buscador principal as bases de dados Literatura Latino-Americana em Ciências em Saúde (LILACS) e Scientific Eletronic Library Online (SCIELO). Os resultados encontrados na pesquisa mostram a importância da prática profissional do enfermeiro relacionado a orientação, educação e diagnóstico precoce da neoplasia. Conclusão: Foi possível concluir que o enfermeiro é profissional qualificado e comprometido com atributos para orientar, prevenir e promover ações de educação em saúde, visando melhorar a qualidade de vida.

Breast Cancer is a disease that affects breast cells, and is one of the main causes of mortality in many women, especially if detected late. Objective: To demonstrate the importance of nurses in the prevention of breast cancer, awareness and awareness of women. Methodology: This is an integrative literature review. Results and discussion: 15 articles were selected for the sample of this review, the publication period analyzed was from 2013 to 2023, the main search engine being the Latin American Literature in Health Sciences (LILACS) and Scientific Electronic Library Online databases ( SCIELO). The results found in the research show the importance of professional nursing practice related to guidance, education and early diagnosis of cancer. Conclusion: It was possible to conclude that the nurse is a qualified and committed professional with attributes to guide, prevent and promote health education actions, aiming to improve the quality of life.

El Cáncer de Mama es una enfermedad que afecta a las células mamarias, y es una de las principales causas de mortalidad en muchas mujeres, especialmente si se detecta tarde. Objetivo: Demostrar la importancia de las enfermeras en la prevención del cáncer de mama, concienciación y sensibilización de las mujeres. Metodología: Se trata de una revisión bibliográfica integradora. Resultados y discusión: 15 artículos fueron seleccionados para la muestra de esta revisión, el período de publicación analizado fue de 2013 a 2023, siendo el principal motor de búsqueda las bases de datos Literatura Latinoamericana en Ciencias de la Salud (LILACS) y Scientific Electronic Library Online ( SCIELO). Los resultados encontrados en la investigación muestran la importancia de la práctica profesional de enfermería relacionada con la orientación, educación y diagnóstico precoz del cáncer. Conclusiones: Fue posible concluir que la enfermera es una profesional cualificada y comprometida con atributos para orientar, prevenir y promover acciones de educación para la salud, con el objetivo de mejorar la calidad de vida.

Perception of the risk factors for oral cancer and access to preventive actions in the perspective of the population in street situation and health professionals Rio Branco, Acre, Brazil / Percepção dos fatores de risco do câncer bucal e acesso as ações de prevenção na perspectiva da população em situação de rua e profissionais de saúde no município de Rio Branco - Acre

Backgroung: in Brazil, the homeless population is a phenomenon that involves a variety of factors that, among the most frequent, are: the rupture of family bonds, the inexistence of work and the absence or insufficiency of income and frequent use of alcohol and other drugs.Objective: to analyze the perception of oral cancer, its risk factors and preventive actions from the perspective of the homeless population and health professionals from the team Clinic on the Street in the city of Rio Branco, Acre, Brazil. Methods: a qualitative study, developed through Content Analysis, carried out from January to April 2018, with the homeless population and health professionals' team of Clinic on the Street in Rio Branco, Acre, Brazil. Results: it was evidenced that the homeless population' situation and the health professionals of Clinic on the Street have perception about the risk factors related to this aggravation, however the users are not concerned with preventive actions. The professionals of the team do not develop actions aimed at the prevention of the disease. From the perspective of the team and the users, preventive actions can be developed, however what is predominant is the accomplishment of punctual actions with emphasis on changing harmful habits. Conclusion: the homeless population and the professionals from Clinic on the Street are aware of the main risk factors for oral cancer. The team does not develop specific actions to prevent this disease and users understand the need for prevention. The difficulty of access and the period of return to the dental surgeon are factors that make prevention difficult.

Introdução: no Brasil, a População em Situação de Rua (PSR) é um fenômeno que envolve uma multiplicidade de fatores, dentre os mais frequentes se encontram: as rupturas dos vínculos familiares, a inexistência de trabalho e a ausência ou insuficiência de renda e o uso frequente de álcool e outras drogas.Objetivo: analisar a percepção sobre o câncer bucal, seus fatores de risco e ações de prevenção na perspectiva dos população em situação de rua e profissionais de saúde da equipe do Consultório na Rua no município de Rio Branco ­ Acre. Método: estudo de abordagem qualitativa, desenvolvida por meio da Análise de Conteúdo, realizada no período de janeiro a abril de 2018 com a população em situação de rua e a equipe de saúde do Consultório na Rua em Rio Branco ­ Acre. Resultados: evidenciou-se que as pessoas em situação de rua e a equipe de saúde do consultório na rua têm percepção sobre os fatores de risco relacionados a este agravo, porém não se tem uma preocupação com a prevenção pelos usuários. Os profissionais da equipe não desenvolvem ações voltadas para prevenção da doença e na perspectiva da equipe e dos usuários, podem ser desenvolvidas ações preventivas, entretanto predomina o olhar para a realização de ações pontuais com ênfase na mudança de hábitos nocivos.Conclusão: a população em situação de rua e profissionais da equipe do consultório na rua têm conhecimento dos principais fatores de risco do câncer bucal. A equipe não desenvolve ações específicas para prevenção deste agravo e os usuários compreendem a necessidade de prevenção. A dificuldade de acesso e o tempo de retorno ao cirurgião dentista são fatores que dificultam a prevenção.

Prevención de cáncer de piel en el Hospital de Clínicas: ¿qué sabe el personal de salud? / Prevention of skin cancer in the Hospital de Clínicas: what do health personnel know? / Prevenção do câncer de pele no Hospital de Clínicas: o que sabem os profissionais de saúde?

El cáncer de piel es la neoplasia maligna más frecuente en Uruguay así como a nivel mundial, donde muere una persona cada menos de cuatro días por ésta causa. La medida de prevención primaria más efectiva es tener hábitos de fotoprotección, lo cual se consigue mediante la educación en salud y campañas preventivas. En el presente trabajo se resumen los resultados del examen físico realizado a funcionarios del Hospital de Clínicas en el contexto de la Campaña de Prevención de Cáncer de Piel 2017 y los hábitos y conocimientos de fotoprotección de los mismos. La amplia mayoría de los asistentes considera que cuenta con información suficiente sobre cómo protegerse del sol, que proviene, en un 39% de los casos de la televisión. Aún asi, el 41% de ellos, sólo se protege en ocasiones especiales como viajes y verano y únicamente 3 de los participantes emplea medidas adecuadas. Con respecto a campañas previas, 94% no recordaba otra campaña de prevención de cáncer de piel y era la primera vez que concurría a una el 99% de los individuos, lo que pone en manifiesto la necesidad de reforzar la planificación y ejecución de campañas y medidas efectivas para la promoción y prevención del cáncer de piel en los próximos años a fin de lograr disminuir la incidencia de cáncer de piel que continúa en aumento.

O câncer de pele é a neoplasia maligna mais frequente no Uruguai e no mundo, onde uma pessoa morre a cada menos de quatro dias por essa causa. A medida de prevenção primária mais eficaz é ter hábitos fotoprotetores, o que é alcançado por meio de educação em saúde e campanhas preventivas. Este artigo sintetiza os resultados do exame físico realizado em funcionários do Hospital de Clínicas no contexto da Campanha de Prevenção do Câncer de Pele 2017 e seus hábitos e conhecimentos sobre fotoproteção. A grande maioria das pessoas considera que possui informações suficientes sobre como se proteger do sol, o que ocorre em 39% dos casos de televisão. Ainda assim, 41% deles são protegidos apenas em ocasiões especiais, como viagens e verão, e apenas 3 dos participantes usam medidas adequadas. Com relação às campanhas anteriores, 94% não se lembraram de outra campanha de prevenção do câncer de pele e foi a primeira vez que 99% dos indivíduos compareceram, o que evidencia a necessidade de reforçar o planejamento e a execução de campanhas e medidas eficazes para a promoção e prevenção do câncer de pele nos próximos anos, a fim de reduzir a incidência de câncer de pele que continua a aumentar.

Skin cancer is the most frequent malignancy in Uruguay as well as worldwide, where a person dies every less than four days for this cause. The most effective prevention measure is to have photoprotective habits, which is achieved through health education and preventive campaigns. This paper summarizes the results of the physical examination performed on officials of the Hospital de Clínicas in the context of the 2017 Skin Cancer Prevention Campaign and their habits and knowledge of photoprotection. The vast majority of individuals consider that they have enough information on how to protect themselves from the sun, which comes in 39% of television cases. Still, 41% of them are only protected on special occasions such as trips and summer and only 3 of the participants use adequate measures. With respect to previous campaigns, 94% did not remember another skin cancer prevention campaign and it was the first time that 99% of the individuals attended, which highlights the need to reinforce the planning and execution of campaigns and effective measures for the promotion and prevention of skin cancer in the coming years in order to reduce the incidence of skin cancer that continues to increase.

Survey on physician attitudes and knowledge toward colorectal cancer screening in primary health care centers, Qassim, Saudi Arabia

Background:Colorectal cancer (CRC) is one of the leading causes of cancer incidence worldwide. In Saudi Arabia, it is ranked first most common cancer in males and second most common in females. CRC is an ideal for prevention because of the high incidence rate and the relative slow progression into an adenocarcinoma. Primary health care (PHC) setting is the ideal place where CRC screening should take place. This study was intended to evaluate awareness, knowledge and attitude towards CRC screening.Methods:A survey was performed among PHC physicians in Qassim province, Saudi Arabia. An electronic questionnaire adopted from the national cancer institute was formulated. Demographic data, specialty, qualifications, years of experience, knowledge and attitudes towards CRC screening, and perceived barriers regarding CRC screening were obtained.Results:A total of 94 physicians were recruited. 39.4% from the sample are females, and 60.6% are males. 99% of physicians agree that colorectal cancer screeningis needed when age appropriate. However, 68% were very compliant in CRC screening in clinical practice. Only 52% of physicians were familiar with national CRC cancer screening guidelines. 53% of physicians scored correct on the age appropriate to initiateCRC screening for average risk patients.Conclusions:More efforts should be given to improve knowledge of primary healthcare providers regarding CRC prevention. More funding and planning are needed to provide primary health care providers with the required tools and systems in order to make CRC prevention more efficient.

Understanding analysis of core knowledge of cancer prevention and treatment in residents of Shanxi Province / 肿瘤研究与临床

Objective:To realize the understanding level of cancer awareness of residents in Shanxi Province, and to provide a scientific basis for cancer prevention and treatment.Methods:In April 2020, 1 897 local residents in Shanxi Province were recruited to fill in the core knowledge questionnaire of cancer prevention and treatment. The basic demographic information and the core knowledge of cancer prevention and control were collected, and the influencing factors for the understanding of the core knowledge of cancer prevention and treatment were analyzed by using multivariate logistic regression model.Results:In the survey on the awareness rate of core knowledge of cancer prevention and control among residents in Shanxi Province, 37 940 items were answered, among which 29 396 items were known, and the awareness rate of the population was 77.48% (29 396/37 940). The single-factor results showed that there were statistically significant differences in awareness rates of core knowledge of cancer prevention and treatment among the population with different gender, household registration, ethnic groups, education degree, occupation and different frequency of the health examination were statistically significant (all P < 0.05); there were no statistically significant differences in awareness rates of core knowledge among the population with different age, and smokers or non-smokers (all P >0.05).Multivariate logistic regression analysis showed that education degree of junior middle school or above ( OR = 3.412-16.767, 95% CI 1.755-32.476) and receiving physical examination once a year ( OR = 2.291, 95% CI 1.154-4.549) were the favorable factors for knowing the core knowledge of cancer prevention and treatment. Household location in rural area ( OR = 0.522, 95% CI 0.378-0.722) and non-Han nationality ( OR = 0.369, 95% CI 0.151-0.904) were the unfavorable factors for knowing the core knowledge of cancer prevention and treatment. Conclusions:The awareness of core knowledge of cancer prevention and treatment among residents in Shanxi Province is good, so it is necessary to continue to strengthen the publicity of cancer prevention and control and improve the awareness of cancer prevention and control in the future.

Abstaining from annual health check-ups is a predictor of advanced cancer diagnosis: a retrospective cohort study

BACKGROUND@#Cancer prevention is a crucial challenge in preventive medicine. Several studies have suggested that voluntary health check-ups and recommendations from health professionals are associated with increased participation in cancer screening. In Japan, it is recommended that individuals aged 40-74 years should undergo annual health check-ups; however, the compliance to this recommendation is approximately <50%. According to the national survey, individuals who do not undergo annual health check-ups are at a higher risk for cancer. However, to the best of our knowledge, no previous study has investigated the association between the use of health check-ups and the incidence rate of cancer. We hypothesised that not undergoing periodic health check-ups and/or less use of outpatient medical services are predictors for advanced cancer.@*METHODS@#To explore the relationship between health check-up or outpatient service utilisation and cancer incidence, this retrospective cohort study used data at two time points-baseline in 2014 and endpoint in 2017-from the National Health Insurance (NHI) claims and cancer registry. A multivariable logistic regression analysis was performed to investigate whether cancer diagnosis was associated with health check-up or outpatient service utilisation.@*RESULTS@#A total of 72,171 participants were included in the analysis. The results of the multivariable logistic regression showed that individuals who skipped health check-ups had a higher risk of cancer diagnosis (odds ratio [OR], 1.21; 95% confidence interval [CI], 1.04-1.40). Moreover, not undergoing health check-ups increased the risk of advanced-stage cancer (OR, 1.78; 95% CI, 1.29-2.44). Furthermore, increased rate of outpatient service utilisation was negatively associated with advanced cancer diagnosis.@*CONCLUSIONS@#This is the first study reporting that not undergoing health check-ups is a predictor of cancer diagnosis and advanced cancer stage. Primary prevention strategies for NHI members who do not undergo health check-ups must be reassessed. Moreover, future research should examine secondary prevention strategies, such as health education and recommendations from health professionals to facilitate adequate utilisation of preventive health services.

Cognition of prevention and control of cervical cancer and influencing factors of HPV vaccination intention among college students in Xiangyang / 公共卫生与预防医学

Objective The knowledge of cervical cancer prevention and control，the cognition of human papillomavirus (HPV) vaccine and the willingness to vaccinate HPV vaccine among college students in Xiangyang were investigated and analyzed to provide a reliable scientific basis for the primary prevention of cervical cancer prevention and control in Xiangyang. Methods By means of stratified sampling method and self-made questionnaire, this paper conducted a questionnaire survey among college students in 3 universities in Xiangyang. Results A total of 8 523 college students participated in the questionnaire survey, and 4 473 of them had sufficient knowledge of cervical cancer prevention and control and HPV vaccine, with the awareness rate of 52.48%. Male students, rural residents and non-medical majors were the influencing factors of insufficient knowledge of cervical cancer prevention and control and HPV vaccine. Among the 6 459 female college students who participated in the survey, 5,993 (92.79%) were willing to be vaccinated, and 859 (13.30%) were already vaccinated. Major, educational background, living expenses and cognitive scores were the influencing factors of HPV vaccination intention. Conclusion College students in Xiangyang City are relatively deficient in the knowledge of cervical cancer prevention and control and HPV vaccine. Targetable science popularization and education can improve college students' correct understanding of cervical cancer prevention and control knowledge, promote the HPV vaccine vaccination plan, and reduce the occurrence of HPV-related diseases and cervical cancer.

The value of PCPT-RC high risk probability combined with Gleason score for predicting the risk of metastasis in newly diagnosed prostate cancer / 西安交通大学学报(医学版)

【Objective】 To investigate the value of prostate cancer prevention trial risk calculator （PCPT-RC） combined with biopsy Gleason score for predicting the risk of metastasis in newly diagnosed prostate cancer patients. 【Methods】 We retrospectively collected the data of 74 patients with newly diagnosed prostate cancer confirmed by biopsy from April 2019 to August 2021， concurrent with 18F-PSMA-1007 PET/CT whole body imaging in the same period. Based on this， a binary logistic regression model was established to obtain the high risk probability of PCPT. We calculated the receiver operating characteristic curve （ROC） was drawn and the area under the curve， Yuden index， sensitivity， specificity， positive predictive value and negative predictive value. We compared the predictive value of the prostate cancer prevention trial risk calculator and Gleason score alone or in combination in predicting the risk of prostate cancer metastasis. 【Results】 Based on the PSMA PET/CT results， 74 patients were divided into non-metastatic group （46/74） and metastatic group （28/74）. PCPT high risk probability ［41.14% （16%-67%）］ vs. ［30.89% （5%-65%）］， Gleason score ［8.5（6-10） score］ vs. ［7.7（6-9） score］， tPSA ［26.24（5.70-42.32） ng/mL］ vs. ［19.58（2.47-49.35） ng/mL］， and fPSA ［3.94（0.82-12.00） ng/mL］ vs. ［2.33（0.35-10.20） ng/mL］ were significantly higher in metastatic group than in non-metastatic group. Binary Logistic regression analysis showed that Gleason score and PCPT low risk probability may be independent predictors of prostate cancer metastasis. PCPT low risk probability alone did not predict the risk of prostate cancer metastasis （P=0.172）. The predictive accuracy of Gleason score and high probability of PCPT in predicting prostate cancer metastasis were 0.715 and 0.679， respectively， and the accuracy of the combined prediction was 0.809. 【Conclusion】 PCPT-RC combined with Gleason score is valuable for predicting the metastasis risk of newly diagnosed prostate cancer patients， which has certain guiding significance for clinical individualized treatment.

Sistema de acciones educativas para desarrollar habilidades psicosociales en el Equipo Básico de Salud para la prevención del cáncer / System of educational actions to develop psychosocial skills in the Basic Health Team for cancer prevention

RESUMEN La investigación tiene como objetivo fundamentar, desde el punto de vista teórico, un sistema de acciones educativas para el desarrollo de habilidades psicosociales del Equipo Básico de Salud para la prevención del cáncer en el Consejo Popular San Juan de Dios. El estudio se llevó a cabo de febrero a julio del 2018 y extiende sus acciones hasta el 2022 pues forma parte de la carpeta de proyectos del Centro para el Desarrollo de las Ciencias Sociales y Humanísticas en Salud. Se realizó un diagnóstico en el cual se utilizaron instrumentos como la entrevista y la encuesta, aplicados a miembros del equipo de salud, a los pacientes oncológicos, sus familiares y población en general, así como a profesionales de la salud de los 13 consultorios del Consejo Popular, aunque fue escogido el número 29 para el estudio piloto. Los resultados obtenidos evidenciaron que existe un insuficiente abordaje psicosocial de la enfermedad por parte del Equipo Básico de Salud.

ABSTRACT The research aims at establishing, from the theoretical point of view, a system of educational actions for the development of psychosocial skills of the Basic Health Team for the prevention of cancer in the San Juan de Dios Popular Council. The study was carried out from February to July 2018 and extends its actions until 2022 as it is part of the project portfolio of the Center for the Development of Social and Humanistic Sciences in Health. A diagnosis was made in which instruments such as the interview and the survey were used, applied to members of the health team, cancer patients, their relatives and the general population, as well as health professionals from the 13 medical offices of the Popular Council. Number 29 was chosen for the pilot study. The results obtained showed that there is insufficient psychosocial approach to the disease bythe Basic Health Team.

Conductas de exposición y protección solar en adolescentes y adultos de la Ciudad de México / Sun exposure and sun protection behaviors among teenagers and adults in Mexico City

Resumen Objetivo: Conocer la prevalencia de las conductas exposición y protección solar en un grupo de adolescentes y compararlos con un grupo de adultos en la Ciudad de México. Material y métodos: Estudio transversal descriptivo en estudiantes de 16 a 18 años y en adultos mayores de 18 años. Resultados: Se encuestaron 748 alumnos, 60 % mujeres y 40 % hombres. El 90 % busca la sombra, el 70.1 % evita exponerse al sol de las 10 a las 16 horas y el 30.6 % usa filtro solar. De 620 adultos, 67.5 % mujeres y 32.4 % hombres, el 82.6 % buscan la sombra, el 60.2 % evita el sol de las 10 a las 16 horas y el 48.1 % utiliza filtro solar. El 72.9 % de adultos y el 80.8 % de adolescentes se exponen al sol debido a actividades domésticas. Discusión: Existe una tendencia similar en las conductas de protección y exposición solar en adolescentes y adultos. Es alta la prevalencia de uso de fotoprotector en adultos en comparación con los adolescentes.

Abstract Objective: To know the prevalence of sun exposure and protection behaviors in a group of adolescents and to compare them with a group of adults in Mexico City. Material and methods: Descriptive, cross-sectional study in students aged 16 to 18 years and in adults older than 18 years. Results: Seven-hundred and forty-eight students were surveyed; 60 % were females and 40 % males; 90 % seek shade, 70.1 % avoid exposing themselves to the sun from 10.00 to 16.00 hours and 30.6 % use sunscreen. Out of 620 adults, 67.5 % were women and 32.4 % were men; 82.6 % seek shade, 60.2 % avoid the sun from 10.00 to 16.00 hours and 48.1% use sunscreen; 72.9 % of adults and 80.8 % of adolescents are exposed to the sun due to domestic activities. Discussion: There is a similar trend in sun protection and exposure behaviors in adolescents and adults. The prevalence of sunscreen use in adults is high in comparison with adolescents.

Therapeutic effects of lamb′s tripe extract and vitamin B12 capsule on precancerous lesions of gastric mucosa in rats / 中华消化杂志

Objective:To explore the therapeutic effects of lamb′s tripe extract and vitamin B12 (hereinafter referred to as lamb′s tripe) capsule on precancerous lesions of gastric mucosa in rats.Methods:Thirty-two rats of the 42 Wistar rats (model group) were selected for modelling, and in model group six rats died due to gavage, 10 rats were sacrificed for observing the results of modeling, and the left 16 rats were divided into administration group (eight rats) and non-administration group (eight rats). After modeling, five of the 10 rats without modelling treatment were selected as the normal control of the model group, the other five (negative control group) rats were included in drug intervention experiment. The drug intervention program was as follows: in administration group, rats were gavaged with lamb′s tripe 0.2 g/kg once per day for three months; in non-administration group and negative control group, rats were gavaged with 0.9% sodium chloride solution 0.2 g/kg once per day for three months. One rat died in each for the administration group and non-administration group due to gavage. Body weight gain, pH value of gastric juice and pathological changes of gastric mucosa of the three groups were evaluated. The number of nodules on gastric mucosal surface and the incidence and scores of precancerous lesions (intraepithelial neoplasia) in gastric mucosal were analyzed. The therapeutic effects of lamb′s tripe capsule on gastric mucosal precancerous lesions in rats were evaluated. Independent sample t test , Mann Whitney U test and chi-square test were used for statistical analysis. Results:The body weight gain of rats at the 6th week in the administration group was higher than that of rats in the non-administration group ((508.26±33.96) g vs. (495.50±23.01) g), and the pH value of gastric juice of rats in the administration group was lower than that of rats in the non-administration group (3.07±0.55 vs. 4.45±0.72), and the differences were statistically significant (both P<0.05). The number of proliferative nodules on the gastric mucosal surface of the rats in the administration group was less than that of rats in the non-administration group (the ratio of gastric fundus: 6.00(3.00, 7.00) vs. 11.00(7.00, 13.00); the ratio of gastric antrum: 0.00(0.00, 1.00) vs. 3.00(2.00, 4.00); the ratio of whole stomach: 7.00(3.00, 10.00) vs. 15.00(13.00, 17.00)), and the differences were statistically significant ( U=43.50, 49.00, 49.00, all P<0.05). The score of gastric mucosal precancerous lesions in the administration group was lower than that in the non-administration group(1.00±0.00 vs.1.14±0.38), and the incidence of precancerous lesions in the administration group was lower than that in the non-administration group (1/7 vs. 5/7), and the differences were statistically significant ( t=2.45, χ2=4.67, both P=0.031). Conclusions:Lamb′s tripe capsule can significantly inhibit the progression of precancerous lesions of gastric mucosa in rats, so as to play a role in preventing the occurrence of gastric cancer.

Aqueous extracts from / 浙江大学学报（英文版）（B辑：生物医学和生物技术）

Hepatocellular carcinoma (HCC), which is the most frequent primary liver malignancy, is ranked as the sixth most common cancer and the third leading cause of cancer-related deaths worldwide, with its incidence expected to continue rising. One of the reasons is that most patients are diagnosed at an advanced stage when therapeutic options are ineffective. The development of HCC is attributed to a chronic exposition to either one or a combination of low amounts of different hepatotoxins, such as in hepatitis virus infection, alcohol consumption, aflatoxin from contaminated foods, metabolic factors, and exposure to chemical carcinogens from tobacco smoke (Forner et al., 2018). Integrative studies combining exome sequencing, transcriptome analysis, and the genomic characterization of HCC have shown that these etiological factors may raise the frequency of particular genetic alterations, resulting in intra-tumor heterogeneity that presents a huge challenge for treatment. For example, mutations in the catenin β-1 (CTNNB1) gene (a proto-oncogene in the WNT signaling pathway that encodes the β‍-catenin transcription factor) are strongly associated with alcohol-related HCC, whereas mutations in the telomerase reverse transcriptase (TERT) promoter and tumor protein p53 (TP53) genes are the most commonly observed in hepatitis B virus (HBV)‍-associated HCC (Calderaro et al., 2017; Cancer Genome Atlas Research Network, 2017). The above findings emphasize the molecular diversity of HCC and the associations of different etiologies with distinct mechanisms in HCC progression. Consequently, prevention strategies are still attractive for HCC management.

Construction of an Information Platform for Cervical Cancer Prevention in the Digital Era / 中国医学科学院学报

The advent of the digital era brings new challenges and opportunities for cervical cancer prevention and research.With the development of digital techniques in China,the construction of an information platform for cervical cancer prevention based on the current achievements has become an important trend.This paper expounds the importance,existing problems,and challenges of the data integration of population-based cervical cancer screening and the information platform construction,and puts forwards effective measures to promote its construction.The establishment of an information platform for cervical cancer prevention in the digital era has far-reaching significance for the global elimination of cervical cancer.

Fundamentos teóricos de la Estrategia de atención psicológica domiciliaria para la prevención y tratamiento del cáncer / Theoretical foundations of the Home Psychological Care Strategy for the prevention and treatment of cancer

RESUMEN La labor psicológica relacionada con la lucha y control del cáncer cobra cada vez mayor importancia, teniendo en cuenta que este se declara entre las primeras causas de muerte a nivel mundial. El presente trabajo científico tiene como objetivo fundamentar, desde el punto de vista teórico, la Estrategia de atención psicológica domiciliaria dirigida a mejorar la prevención y tratamiento del cáncer en el Consejo Popular San Juan de Dios, desde un enfoque biopsicosocial, con énfasis en la atención integral a domicilio al paciente dispensarizado por cáncer y a su familia. Además, se exponen las distintas etapas que la conforman, sus objetivos y las acciones que se ejecutaron. Para el estudio piloto se seleccionó el consultorio médico 29 del área de salud perteneciente al Policlínico Universitario José Martí Pérez, de Camagüey. Los resultados actuales derivan del proyecto de investigación Estrategia de intervención sociopsicológica para la prevención y tratamiento del cáncer en la atención primaria de Salud, que gestiona el Centro para el Desarrollo de las Ciencias Sociales y Humanísticas en Salud, de la Universidad de Ciencias Médicas de Camagüey y cuyo proceso de ejecución corresponde al período 2016-2021.

ABSTRACT Psychological work related to the fight and control of cancer is becoming increasingly important, taking into account that it is declared among the leading causes of death worldwide. The present scientific work aims to establish, from a theoretical point of view, the Home Psychological Care Strategy aimed at improving the prevention and treatment of cancer in the San Juan de Dios Popular Council, from a biopsychosocial approach, with an emphasis on Comprehensive home care for cancer patients and their families. In addition, the different stages that comprise it, their objectives and the actions that were carried out are exposed. For the pilot study, medical office 29 of the health area belonging to the José Martí Pérez University Polyclinic, in Camagüey, was selected. The current results derive from the research project Socio-psychological intervention strategy for the prevention and treatment of cancer in primary health care, which manages the Center for the Development of Social and Humanistic Sciences in Health, of the University of Medical Sciences of Camagüey and whose execution process corresponds to the period 2016-2021.

UV protection for young athletes: using participatory program planning to develop a sports schools program

BACKGROUND@#The incidence of melanoma increased rapidly throughout the last decades, with overexposure to ultraviolet (UV) radiation being an established risk factor. Due to their intensive sun exposure, many student athletes (SAs) have an increased risk for skin cancer. The Clever in Sun and Shade Program (CSSP) aims at enforcing positive attitudes toward UV protection (UVP) and at supporting sports schools in establishing UVP strategies.@*METHODS@#CSSP was developed in 2019 using participatory program planning (PPP) as well as following WHO recommendations for UVP at schools. After drafting first material, within a PPP groups were conducted at a partner school (convenience sample 1) with students (n = 20), teachers (n = 5), school administration (n = 2), and coaches (n = 5). Materials were then adapted. Program acceptance and feasibility were tested at two further schools (convenience sample 2) with PPP groups of students (n = 95) and school administration (n = 2). Content analyses and descriptive statistics were conducted.@*RESULTS@#Less than 50% of SAs and coaches of sample 1 expressed positive attitudes toward UVP, less than 10% reported appropriate UVP behavior. By using PPP, program material was adapted to the target groups' needs, i.e., by including specific barriers and solutions. Only the most accepted video drafts were produced. The majority of SAs of sample 2 (80-86%) used predominantly positive adjectives such as "important" and "positive" to describe the completed videos and the behavior self-check poster.@*CONCLUSIONS@#PPP process has greatly influenced concept and materials of CSSP for sports schools. Integration of future program participants has proven to be an important component in creating a fitting and feasible program. CSSP for sports schools is a program free of charge that enables sports schools to integrate UVP into their daily routine. It will be disseminated in cooperation with German Olympic Sports Confederation and German Cancer Aid in 2021.

Study on the risk factors of gastric cancer / Монголын Анагаах Ухаан

Introduction@#In 2018, a total of 901 new cases of gastric cancer were recorded, of which 64.8% in males and 34.2% in females. The incidence rate of gastric cancer was 28.5 per 100 000 population, which 38.2 for males and 19.2 for females.@*Goal@#We aimed to investigate the associations between some risk factors and gastric cancer among the Mongolian population. @*Materials and Methods@#A case-control study was conducted between November 2017 and September 2019. We selected 120 cases from National cancer center of Mongolia who newly diagnosed gastric cancer. And 120 controls were selected by matching by sex, age and the place of residence. Informed consents were obtained from all subjects. All subjects were personally interviewed with researchers used by a structured questionnaire consisting of 86 questions. The SPSS 21 (version 16.0, SPSS Inc., Chicago, IL, USA) software was used for all analyses.@*Results@#The mean age was 59.2±11.4 (26-85) years. Habits of having dinner after 6.00 pm (OR 1.42, 95%CI 1.11-1.83, p=0.008), having leftover meals (OR 2.22, 95%CI 1.27-3.86, p=0.008), daily consumption of tea with salt (OR 1.97, 95%CI 1.18-3.30, p=0.01), smoking on an empty stomach (OR 2.44, 95%CI 1.11-5.37, p=0.033), weekly consumption of ham and smoked meat (OR 1.5, 95%CI 1.17- 2.13, p=0.02), and consumption of fat grease (OR 2.09, 95%CI .03-4.24, p=0.038) were significantly increased gastric cancer risk. In contrast, habit of eating at regular times (OR 0.43, 95%CI 0.25-0.73, p=0.002), chewing thoroughly (OR 0.39, 95%CI 0.23-0.67, p=0.001), cooking meat thoroughly until it’s tender (OR 0.48, 95%CI 0.25-0.97, p=0.047), daily consumption of vegetables (OR 0.45, 95%CI 0.27-0.76, p=0.003), and daily consumption of fruit juice (OR 0.36, 95%CI 0.15-0.85, p=0.026) were significantly reduced gastric cancer risk. Furthermore, having first-degree relatives diagnosed with gastric cancer had 2-3 fold higher increased risk of gastric cancer (parents OR 2.88, 95%CI 1.07- 7.78, p=0.038, sibling (OR 3.09, 95%CI 1.09-8.81, p=0.036). Also, previous records of the digestive disease increased risk of gastric cancer (OR 3.65, 95%CI 2.10-6.35, p<0.0001).@*Conclusion@#Dietary habits, family history of gastric cancer and previous records of digestive disease were associated with risk of gastric cancer. Thus, prevention effort could be focused on the population with a family history of gastric cancer, changing bad dietary habit and screening precancerous disease of gastric cancer.

Health literacy and cancer prevention / 中华预防医学杂志

This article reviews the literature on health literacy and cancer prevention, screening, treatment and prognosis. A large number of studies have shown that health literacy is positively correlated with public cancer risk awareness, cancer knowledge awareness rate, and cancer screening behavior, and positively correlated with the health service resource utilization ability of cancer patients, treatment compliance, and quality of life, and negatively correlated with the unhealthy lifestyle such as smoking and drinking. Some studies have problems such as small sample size, limited population, and inappropriate design. Some studies do not support the conclusions above. Therefore, multi-center, large-scale clinical studies and cohort studies should be conducted to provide more robust evidence for the relationship between the health literacy and cancer prevention, screening, and treatment.

Study on the health literacy and related factors of the cancer prevention consciousness among urban residents in China from 2015 to 2017 / 中华预防医学杂志

Objective@#To understand the health literacy and relevant factors of cancer prevention consciousness in Chinese urban residents from 2015 to 2017.@*Methods@#A cross-sectional survey was conducted in 16 provinces covered by the Cancer Screening Program in Urban China from 2015 to 2017. A total of 32 257 local residents aged ≥18 years old who could understand the investigation procedure were included in the study by using the cluster sampling method and convenient sampling method. All local residents were categorized into four groups, which contained 15 524 community residents, 8 016 cancer risk assessment/screening population, 2 289 cancer patients and 6 428 occupational population, respectively. The self-designed questionnaire was used to collect the information of demographic characteristics and cancer prevention consciousness focusing on nine common risk factors, including smoking, alcohol, fiber food, food in hot temperature or pickled food, chewing betel nut, helicobacter pylori, moldy food, hepatitis B infection, estrogen, and exercise. The logistic regression model was adopted to identify the influencing factors.@*Results@#The overall health literacy of the cancer prevention consciousness was 77.4% (24 980 participants), with 77.4% (12 018 participants), 79.9% (6 406 participants), 77.2% (1 766 participants) and 74.5% (4 709 participants) in each group (P<0.001). The correct response rates for nine risk factors ranged from 55.2% to 93.0%. The multivariate logistic regression analysis showed that compared with community residents, people with primary school level education or below, and the number of people living together in the family <3, the cancer risk assessment/screening intervention population, cancer patients, those with junior high school level educationor above and the number of people living in the family ≥3 had better health literacy of the cancer prevention consciousness (all P values <0.05). Compared with females, 39 years old and below, government-affiliated institutions or civil servants, from the eastern region, males, older than 40 years, company or enterprise employees, and from the middle or western region had worse health literacy of the cancer prevention consciousness (all P values <0.05).@*Conclusion@#The health literacy of the cancer prevention consciousness in Chinese urban residents should be improved. The cancer screening intervention, gender, age, education, occupation, the number of people co-living in the family, and residential region were associated with the health literacy of the cancer prevention consciousness.