Cardiomiopatía dilatada en un cachorro: reporte de un caso / Cardiomiopatia dilatada em um cachorro: reporte de um caso / Dilated cardiomiopathy in a puppy: a case report

En este reporte se expone el caso de una cachorra de raza Springer Spaniel que presentaba taquipnea, ascitis, intolerancia al ejercicio, leve cianosis y baja condición corporal. A la auscultación cardiaca se evidenció un soplo 5/6 mitral que irradiaba a ambos hemitórax. En la ecocardiografía se apreció una disminución de la función contráctil del ventrículo izquierdo, hipertrofia excéntrica del atrio y ventrículo izquierdo, e insuficiencia mitral.

This is a case of a Springer spaniel puppy which presented tachypnea, ascitis, exercise intolerance, mild cyanosis and a poor body condition. At cardiac auscultation a 5/6 mitral murmur was detected that irradiated to both hemithorax. Echocardiography revealed diminished left ventricular contractility, eccentric hypertrophy of the left atrium and ventricle and mitral insufficiency.

Este relatório descreve o caso de uma cachorra da raça Springer spaniel de baixa condição corporal que tinha taquipnéia, ascite, intolerância ao exercício, cianose leve. Na ausculta cardíaca foi mostrado um fôlego 5/ 6 mitral que irradiava ambos hemitórax. Em ecocardiografia revelou uma diminuição na função contrátil do ventrículo esquerdo, excêntrica hipertrofia do ventrículo direito e átrio esquerdo e insuficiência mitral.

The Effect of Esmolol Combined with Nitroglycerin on Cardiac Hemodynamics and Myocardial Oxygen Balance during Cross-Clamping of Thoracic Aorta in Induced Ischemic Canene Heart / 대한마취과학회지

The purpose of this study is to investigate the protective role of esmolol during cross-clamping of descending thoracic aorta on the ischemic myocardium induced by the ligation of the left anterior descending coronary artery(LAD) in dogs. LAD was ligated for 15 min followed by reperfusion. Nitroglycerin with or without esmolol were continuously infused throughout procedure and the thoracic aorta was cross-clamped for 45 mins. Eighteen dogs were divided into three groups; group C-no drug administerd, group N-nitroglycerin(5 ug/kg/min), and group NE-nitroglycerin(5 ug/kg/min) with esmolol(0.5 mg/kg as loading dose following 50 ug/kg/min as maintenance dose). Heart rate(HR), mean arterial pressure(MAP), stroke volume(SV), cardiac index(CI), left ventricular stroke work index(LVSWI), pulmonary capillary wedge pressure(PCWP), triple index(TI), mixed venous oxygen tension of great cardiac vein(PgvO2), Ca-vDO2(carotid arterial oxygen content-great cardiac vein oxygen content) and lactate were measured three times in each group before ligation of LAD(stage 1), 15 minutes after LAD ligation(stage 2) and 45 minutes after cross-clamping of descending thoracic aorta(stage 3). The results were as follows: 1) MAP of group NE at stage 3 was significantly high compared with group C but low compared with group N (P<0.05). 2) SV of group NE at stage 3 was significantly high compared with group C and group N. A significant change was observed between group C and group N(P<0.05). 3) CI, LVSWI, PgvO2 of group NE at stage 3 were significantly high compared with group C but not significantly high compared with group N(P<0.05). 4) HR, PCWP, Lactate level of group NE at stage 3 were significantly low compared with group C and group N. A significant change was also observed between group C and group N(P<0.05). 5) TI, Ca vDO2 of group NE at stage 3 were significantly low compared with group C and group N, but no significant change was observed between group C and group N(P<0.05). These results suggest that esmolol could protect ischemic myocardium from progressive damage via reduction of myocardial oxygen consumption without decrease of cardiac output and left ventricular stroke work index.