ABSTRACT
Dietary advice forms the cornerstone in the management of cardiometabolic disease. Though various national and international guidelines suggest different macronutrient proportions, locally framed person-centric diet prescriptions are likely to have a better compliance. In this article, we propose an indigenous traditional Indian Ocean (TRIO) diet, which constitutes a similar pattern of the dietary practices followed by inhabitants of the Indian Ocean littoral region. The TRIO diet highlights on concepts of procurement, preparation, presentation, prioritization, preservation and partaking and may be a good alternative to the Mediterranean diet followed in western countries.
ABSTRACT
Cardiometabolic disease （CMD） is a clinical syndrome in which there is a causal relationship between metabolic abnormalities and cardiovascular damage. The incidence and mortality rates of CMD remain high despite the use of potent pharmacologic interventions and clinical therapeutic approaches. There is an urgent need for effective evidence-based comprehensive management measures to improve patients' lifespan and quality of life. From the concept of "nourishing through food" proposed in the Huangdi's Internal Classic （Huang Di Nei Jing） to the widespread application of modern dietary patterns such as dietary restriction， plant-based diets， and Jiangnan cuisine， dietary regulation plays a significant role in preventing diseases， early treatment of existing diseases， and recovery. This article systematically reviewed the traditional Chinese medicine （TCM） theory related to dietary patterns， elucidated the cutting-edge evidence and mechanisms of modern dietary patterns like dietary restriction in preventing and treating CMD， and explored the strategy of integrating TCM theory with dietary patterns， aiming to establish a new food-nutrition-medicine approach that combines traditional Chinese and western medicine and provide novel insights and directions for the clinical management of CMD.
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Objective: To explore the distribution patterns of cardiometabolic diseases (CMD) in elderly patients with colorectal cancer, and provide a reference for the prevention and treatment of cardiovascular metabolic diseases in these patients. Methods: Clinical data of 3 894 elderly patients with colorectal cancer from January 2008 to March 2018 admitted in the Chinese PLA General Hospital were recruited and the incidence rate of CMD was retrospectively analyzed. The influence factors of elderly patients with colorectal cancer combined with CMD were analyzed by multivariate Logistic regression model. Results: The morbidity rate of CMD in elderly patients with colorectal cancer is 33.4% (1 301/3 894), among them, the morbidity rate of the male was 31.9% (768/2 409), and that of the female was 35.9% (533/1 485). There was not significant difference between these two sex (P=0.074). The morbidity rates of CMD in patients of 65-74 years, 75-84 years and ≥85 years were 30.6% (754/2 462), 37.0% (479/1 294) and 49.3% (68/138), respectively, with significant differences (P<0.001). Multiple Logistic regression analysis revealed that female (OR=1.213, 95%CI: 1.056-1.394), age (75-84 years group: OR=1.344, 95%CI: 1.164-1.552; ≥85 years group: OR=2.345, 95%CI: 1.651-3.331) and body mass index (BMI 18.5-24.9 kg/m(2) group: OR=1.319, 95%CI: 1.065-1.638; ≥25 kg/m(2) group: OR=2.041, 95%CI: 1.627-2.561) were independent risk factors for elderly colorectal cancer patients with CMD. Conclusion: The morbidity rate of CMD in elderly patients with colorectal cancer increases with age and it is urgent to strengthen multidisciplinary cooperation and develop reasonable treatment plans to extend the survival and life quality of these patients.
Subject(s)
Aged , Aged, 80 and over , Female , Humans , Male , Cardiovascular Diseases , China/epidemiology , Colorectal Neoplasms , Retrospective Studies , Risk FactorsABSTRACT
Early adulthood is a critical stage in life cycle. Weight change during this period boasts several significant physiological features, and is suggested to have an effect on future cardiometabolic health. However, few studies have systematically described the association of weight change in early adulthood with long-term cardiometabolic risk. Therefore, we tried to comprehensively summarize the influence of different weight change patterns during early adulthood on cardiovascular diseases, and discuss some potentials in future research.
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Cardiometabolic disease is an interrelated constellation of diseases such as hypertension, diabetes, dyslipidemia, coronary heart disease and stroke, leading to great threats to public health and increasing burden of diseases in China. The important and essential action to prevent cardiometabolic diseases is to promote healthy lifestyle throughout life. This guideline provides recommendations on diet and beverage, physical activity, smoking, drinking and other lifestyle habits, mainly based on evidence derived from Chinese studies. The recommendations are developed to guide actions in living a healthy lifestyle for primary prevention of cardiometabolic diseases among Chinese adults, and also to promote the implementation of the Healthy China initiative.
ABSTRACT
Cardiometabolic disease is an interrelated constellation of diseases such as hypertension, diabetes, dyslipidemia, coronary heart disease and stroke, leading to great threats to public health and increasing burden of diseases in China. The important and essential action to prevent cardiometabolic diseases is to promote healthy lifestyle throughout life. This guideline provides recommendations on diet and beverage, physical activity, smoking, drinking and other lifestyle habits, mainly based on evidence derived from Chinese studies. The recommendations are developed to guide actions in living a healthy lifestyle for primary prevention of cardiometabolic diseases among Chinese adults, and also to promote the implementation of the Healthy China initiative.
ABSTRACT
La importancia de la nutrición en modificar el riesgo de enfermedad cardiovascular aterosclerótica (ECVA) se ha enfatizado repetidas veces. Históricamente, el papel de los componentes dietarios ha sido el foco predominante; sin embargo, los alimentos, típicamente, se consumen en combinación más que aisladamente. En los últimos años, se ha puesto una mayor atención a los patrones dietarios y su relación con eventos clínicos del tipo de la ECVA, diabetes mellitus tipo 2 y obesidad; paradójicamente, existe una brecha en la educación nutricional en las escuelas de medicina de todo el mundo. Por lo general, una dieta no saludable está asociada con alteraciones cardiometabólicas, una condición clínica que, gradualmente, puede empeorar y conducir a diversos factores comunes de riesgo de enfermedades crónicas, a mayor morbilidad y mortalidad y menoscabo en la calidad de vida. El público en general debe satisfacer la cantidad de calorías requeridas con una variedad de alimentos densos en nutrientes que abarquen todos los grupos de alimentos para mantener la salud a largo plazo. El estilo de patrones saludables de comer varía individualmente y frecuentemente refleja las preferencias culturales y personales. Una alimentación no saludable puede causar una elevación de la producción posprandial de insulina e hipersecreción crónica de insulina e hiperinsulinemia, lo cual promueve la acumulación de grasa, previene la lipólisis y causa incremento en el riesgo de desarrollar ECVA, obesidad y diabetes tipo(AU)
The importance of nutrition in modifying the risk of atherosclerotic cardiovascular disease (ACVD) has been repeatedly emphasized. Historically, the role of dietary components has been the predominant focus; however, foods are typically consumed in combinations rather than individually. Over the last few years, increasing attention has been given to dietary patterns and their relationship to clinical events such as ACVD, type 2 diabetes and obesity; paradoxically, there is a gap in nutrition education in medical school around the globe. An unhealthy diet is usually associated with cardiometabolic alterations, a clinical situation that can progressively worse, potentially leading to various common risk factors, increased morbidity and mortality, and reduced quality of life. People should aim to fulfill their recommended calorie intake with a variety of nutrient-dense foods that span all food groups to boost long-term health. Healthy eating styles may vary from individual to individual and frequently reflect cultural and personal preferences. An unhealthy diet may cause a high postprandial insulin production and chronic insulin hypersecretion and hyperinsulinemia, which promote fat storage, prevent lipolysis and cause increased the risk for developing ACVD, obesity and type 2 diabetes
Subject(s)
Humans , Male , Female , Cardiovascular Diseases/physiopathology , Diabetes Mellitus, Type 2 , Atherosclerosis , Obesity , Nutritional Sciences , Diet, Food, and Nutrition , Nutritional RequirementsABSTRACT
Microvesicles (MVs, also known as microparticles) are small vesicles that originate from plasma membrane of almost all eukaryotic cells during apoptosis or activation. MVs can serve as extracellular vehicles to transport bioactive molecules from their parental cells to recipient target cells, thereby serving as novel mediators for intercellular communication. Importantly, more and more evidence indicates that MVs could play important roles in early pathogenesis and subsequent progression of cardiovascular and metabolic diseases. Elevated plasma concentrations of MVs, originating from red blood cells, leukocytes, platelets, or other organs and tissues, have been reported in various cardiometabolic diseases. Circulating MVs could serve as potential biomarkers for disease diagnosis or therapeutic monitoring. In this review, we summarized recently-published studies in the field and discussed the role of MVs in the pathogenesis of cardiometabolic diseases. The emerging values of MVs that serve as biomarker for non-invasive diagnosis and prognosis, as well as their roles as novel therapeutic targets in cardiometabolic diseases, were also described.
Subject(s)
Humans , Biomarkers , Metabolism , Cardiovascular Diseases , Blood , Diagnosis , Therapeutics , Cell Communication , Cell-Derived Microparticles , Metabolism , Metabolic Diseases , Blood , Diagnosis , TherapeuticsABSTRACT
A national nutrition surveillance system is an essential instrument for the detection of nutrition and nutrition-related health problems that can assist on policy implementation. The role of nutritional surveillance in detecting trends of nutritional problems and predicting their risks has become more important as its strong scientifically based method and evidences may provide insights on chronic disease risks. In this review, we attempted to identify dietary issues of Korean cardiometabolic disease (CMD) based on the national nutrition surveillance system and addressed gaps and limitations in the system. In addition, an alternative way on how the system can overcome these problems with the view of ultimately improving public health in Korea was discussed.
Subject(s)
Chronic Disease , Korea , Methods , Nutrition Policy , Public HealthABSTRACT
PURPOSE: In line with epidemiological and sociocultural changes in Korea over the past decades, reliable estimation of diseases as a result of dietary and metabolic risks is required. In this study, we aimed to evaluate the contributions of dietary and metabolic factors to cardiometabolic diseases (CMDs) in Korean adults (25–64 years old) during 2012–2013. MATERIALS AND METHODS: Distribution of risk factors and cause-specific mortality by gender and age per year was obtained from the Korea National Health and Nutrition Examination Survey and Statistics Korea, respectively. The association between the two was obtained from published meta-analyses. The population-attributable fraction attributable to the risk factors was calculated across gender and age strata (male and female, age groups 25–34, 35–44, 45–54, and 55–64) in 2012 and 2013. RESULTS: The results showed that during the period studied, high body mass index [5628 deaths; uncertainty intervals (UIs): 5473–5781] and blood pressure (4202 deaths; UIs: 3992–4410) were major metabolic risks for CMD deaths, followed by dietary risks such as low intake of whole grain (4107 deaths; UIs: 3275–4870) and fruits (3886 deaths; UIs: 3227–4508), as well as high intake of sodium (2911 deaths, UIs: 2406–3425). Also, males and the younger population were seen more prone to be exposed to harmful dietary risk than their female and older counterparts. CONCLUSION: The findings provide the necessary information to develop targeted government interventions to improve cardiometabolic health at the population level.
Subject(s)
Adult , Female , Humans , Male , Blood Pressure , Body Mass Index , Cardiovascular Diseases , Diabetes Mellitus , Fruit , Korea , Mortality , Nutrition Surveys , Risk Factors , Sodium , Uncertainty , Whole GrainsABSTRACT
Las enfermedades cardiometabólicas ocupan el primer lugar en morbimortalidad en todo el mundo, como enfermedades crónicas no transmisibles. La detección de los factores de riesgo para el desarrollo de estas enfermedades representa la herramienta fundamental del clínico para evitar la morbimortalidad de la población por enfermedad cardiometabólica. El proceso ateroesclerótico comienza a desarrollarse desde la primera década de la vida, detectándose cada vez más a menor edad la presencia de enfermedad cardiovascular y metabólica en la población infantojuvenil. Por tal motivo, la identificación temprana del paciente en riesgo es prioritaria y debe generar intervención del equipo de salud para evitar complicaciones a futuro (prevención primordial y prevención primaria). Al identificar el individuo en riesgo, se realiza una intervención positiva modificando sus factores de riesgo para enfermedad cardiovascular, logrando cambiar su riesgo global y la prevención será más eficiente. El objetivo de este proyecto es desarrollar un instrumento sencillo y práctico que pueda aplicarse fácilmente en la mayoría de la población, dirigido al médico pediatra, de familia o general, para identificar precozmente el paciente en riesgo cardiometabólico global en edades pediátricas, con el fin de modificar estos factores y educar sobre la prevención de las enfermedades cardiometabólicas.
Cardiometabolic diseases occupy the first place in morbidity and mortality worldwide, as non-communicable chronic diseases. The detection of risk factors for the development of these diseases represents a fundamental tool for the clinician in order to prevent cardiometabolic disease morbidity and mortality. The atherosclerotic process begins to develop during the first decade of life, with cardiovascular and metabolic disease appearing with increasing frequency at early ages. For this reason, early identification of patients at risk is a priority and should motivate intervention of the health team in order to prevent future complications (primary prevention and primordial prevention). Individuals at risk are submitted to a positive intervention by modifying risk factors for cardiovascular disease, which will change overall risk and achieve a more efficient prevention. The objective of this project is to develop a simple and practical tool that can be applied in the majority of the population, aimed for pediatricians and family or general physicians, in order to identify patients with global cardiometabolic risk at an early age, and to modify these factors and educate in the prevention of cardiometabolic disease.
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Transient receptor potential vanilloid type-1 channel (TRPV1) is a non-selective cation channel with a preference for calcium ions that is able to sense a vast range of endogenous physical and chemical stimuli and plays an important role in transducing the sensations of noxious heat and pain signaling. Recent studies showed that TRPV1 is widely expressed in different tissues and organs beyond the sensory nerves and has multiple biological effects that are involved in functional regulation in the pancreas, blood vessel, adipose tissue and liver. To further understand the link between TRPV1 and cardiometabolic diseases, we reviewed the role of TRPV1 in hypertension, diabetes, obesity, and dyslipidemia. This review provides new insights into the involvement of TRPV1 channels in the pathogenesis of cardiometabolic disorders and implicates this channel as a potential therapeutic target for the management of cardiometabolic diseases.
Subject(s)
Adipose Tissue , Aluminum Hydroxide , Blood Vessels , Calcium , Capsaicin , Carbonates , Dyslipidemias , Glycosaminoglycans , Hot Temperature , Hypertension , Ions , Liver , Obesity , Pancreas , SensationABSTRACT
El objetivo del estudio fue categorizar el riesgo a sufrir enfermedades cardiometabólicas a partir del uso de biomarcadores del metabolismo de los lípidos y proteínas en estudiantes deportistas o sedentarios de la Universidad Central de Venezuela. Se determinó en suero de 103 sujetos (55 deportistas y 48 sedentarios), por método colorimétrico: creatinina (Cr), proteína total (Pt), albúmina (Al), triglicéridos (Tg), colesterol total (Col-T), y lipoproteínas de alta densidad (HDL-C), mientras que la de baja densidad (LDL-C) se obtuvo por la fórmula de Friedewald y las globulinas por la resta entre Pt y Al. Los niveles séricos de los biomarcadores se encontraron dentro de los rangos de referencia. Sólo en las HDL-C y las globulinas no se observaron diferencias significativas entre sedentarios y deportistas. En estos últimos se consiguieron los Tg notablemente bajos, mientras que el Col-T fue alto, principalmente a expensa de la LDL-C. En este grupo, la condición de los diferentes componentes del perfil lipídico y del índice Col-T/HDL-C estuvieron influenciadas por una distorsión transitoria de la lipemia, posiblemente asociada a procesos inflamatorios mediados por respuesta inmune que se presenta en actividad física de alta intensidad. Se detectó baja proporción de HDL-C elevado en sedentarios y deportistas. Apenas 2,1 por ciento de los sedentarios y 1,0 por ciento de la muestra total tuvieron albúmina sérica baja, la cual está asociada a riesgo incrementado a sufrir enfermedades cardiovasculares (ECV). Una pequeña proporción de la muestra evaluada pudiera ser susceptible a sufrir algún tipo de enfermedad cardiometabólica
The main objective of this study was to categorize the risk of suffering of cardiometabolic disease. For this, lipids and proteins metabolic biomarkers were used on sporting or sedentary students from Universidad Central de Venezuela. The following parameters were determined by colorimetric methods: Creatinine (Cr), Total protein (Tp), Albumin (Al), Triglycerides (Tg), Total cholesterol (T-Cho) and High density lipoproteins (HDL-C). The low density lipoproteins (LDL-C) were calculated by using the Friedewald formulae and globulins values were obtained by subtracting Tp from Al. The seric biomarkers levels were in the normal reference ranges. There were not significant differences on the HDL-C and globulins values between sporting and sedentary students. The sporting group showed very low Tg levels, with high T-Cho, due mainly to LDL-C. In this group, the conditions of the different components of the lipidic profile and T-Cho/HDL-C rate were influenced by a transitory lipemic distortion, possibly due to inflammatory mechanism mediated by immune response, which is observed in physical activity of high intensity. Low levels of HDL-C were obtained from both studied groups. Only 2,1 percent from the sedentary group and 1,0 percent of total sample showed low levels of albumin, which is associated to high risk of suffering from cardiovascular disease. Only a small part of the evaluated sample could be susceptible of suffering cardiometabolic disease