Association between subjective sleep quality and blood pressure at rest and during exercise in free-living conditions in young women: A pilot study / 体力科学

Sleep disorders are risk factors for hypertension. This adverse effect is especially affected in women. Nevertheless, the impact of sleep habits on the cardiovascular response remains unclear in young women. This study aimed to determine whether sleep habits could affect blood pressure regulation at rest and during exercise in young women. Twenty-two young women participated in this study. The Pittsburgh Sleep Quality Index (PSQI), resting blood pressure (BP), and BP response to the 2-minute isometric handgrip exercise, which consists of 25% maximum force production using left hand, were measured. Beat-by-beat arterial BP changes during exercise was measured using the Finapres™ device, and it was averaged every 30 sec before and during exercise; BP reactivity was evaluated by the delta change from rest to exercise. The PSQI score was 5.2 ± 2.2. The resting systolic and diastolic BPs were 105 ± 7 mmHg and 62 ± 7 mmHg, respectively. BP reactivity to the exercise were Δ 4 ± 7 mmHg, Δ 4 ± 7 mmHg, Δ 6 ± 7 mmHg, and Δ 7 ± 9 mmHg, for each 30-sec interval. Poorer sleepers (PSQI > 4.5) showed a tendency toward lower resting systolic BP compared with better sleepers (PSQI < 4.5) (p = 0.069). Systolic BP reactivity to the last 30 sec of exercise was correlated with the PSQI score (r = 0.484, p = 0.022). In conclusion, sleep quality may affect the cardiovascular regulation at rest and during exercise in young women.

Gαq-RGS2 loop activator modulates the activity of vario us agonists on isolated heart and aorta of normal rats

The Gαq-RGS2 loop activator, 1-(5-chloro-2-hydroxyphenyl)-3-(4-(trifluoromethyl)-phenyl)-1H-1,2,4-triazol-5(4H)-one has demonstrated Gαq signaling inhibitor activity. Therefore, we aimed to study the effect of Gαq-RGS2 loop activator on isolated heart and aorta of normal rats. Heart and aorta were isolated from the sacrificed rats (n=6) and mounted on the langendroff's and organ bath assembly, respectively. The effect of various receptor-dependent (acetylcholine, angiotensin II and adrenaline) and independent (calcium chloride and sodium nitroprusside) agonists in absence and presence of Gαq-RGS2 loop activator on left ventricular systolic pressure (LVSP) and the contractile responseswere evaluated in isolated heart and aorta, respectively. Gαq-RGS2 loop activator (100 µM) significantly attenuated the adrenaline (p<0.001,) and angiotensin II (p<0.001) induced increase in LVSP in isolated heart and contractile response of adrenaline (p<0.01) and angiotensin II (p<0.01) in the aorta. However, effect calcium chloride did not significantly alter by Gαq-RGS2 loop activator. The effect of acetylcholinewas significantly (p<0.01, p<0.05) increased by Gαq-RGS2 loop activator in isolated heart and aorta. The effect of sodium nitroprusside significantly (p<0.01) potentiated by Gαq-RGS2 loop activator (100 µM) in isolated heart while it did not significantly alters in the aorta. Ultimately, the Gαq-RGS2 loop activator modulated the action of receptor-dependent agonists in isolated heart and aorta

To Compare the Cardiovascular Reactivity to Mobile Games Induced Stress In Medical Students

Background: Students usually prefer to play games on theirmobile phones to avoid stress which is a major cause of CVDnowadays. CVR to stress can be assessed throughcardiovascular parameters such as blood pressure, heart rateand pulse transit time. The present study was conducted tocompare the Cardiovascular Reactivity (Heart rate, bloodpressure, pulse transit time) before, during and after playingmobile games and to compare cardiovascular parameters onthe 1st day and last day of study.Materials and Methods: This cross-sectional study wasconducted among 100 MBBS students in the age group of 19to 22 years at KD Medical College, Hospital and ResearchCentre, Mathura. Subjects over the period of 2 months wereselected for the study. The subjects were asked to have a lightbreakfast. Then in the sitting position; cardiovascularparameters and anthropometric data of the subjects weretaken 10 minutes before the game. All the rules of(CRASHLAND) mobile game were explained to the subjectsbefore letting him/her to start the game. After taking theseparameters the subject were asked to play the mobile game for30 minutes. Then the game was withdrawal and within 10minutes of interval; all these parameters were taken again. Ifany discomfort was reported by the subject then he/she wasexcluded from this study. Data was analyzed using SPSSversion 20. Variation of Cardiovascular Reactivity before,during and after playing mobile games were accessed byRepeated Measure ANOVA. Comparison of cardiovascularparameters on the 1st day and last day of study of a subjectwas accessed by Paired “t” Test.Results: A positive correlation was found between the BMIand various CVR parameters such as heart rate, SBP, DBP,MAP, pulse transit time, pulse wave velocity during and afterplaying the game. Repeated measure ANOVA analysed thatthere was no significant increase in pulse wave velocity of thesubject before, during and after playing mobile game. One wayANOVA analysed that there was significant increase in SBPand DBP of the subject, suggesting increased stressassociated with playing mobile games.Conclusion: Our study concluded that a positive correlationwas found between the BMI and various CVR parameters suchas heart rate, SBP, DBP, MAP, pulse transit time, pulse wavevelocity during and after playing the game.

Symptoms of anxiety and depression are related to cardiovascular responses to active, but not passive, coping tasks

Objective: Anxiety and depression have been linked to blunted blood pressure (BP) and heart rate (HR) reactions to mental stress tests; however, most studies have not included indices of underlying hemodynamics nor multiple stress tasks. This study sought to examine the relationships of anxiety and depression with hemodynamic responses to acute active and passive coping tasks. Methods: A total of 104 participants completed the Hospital Anxiety and Depression Scales and mental arithmetic, speech, and cold pressor tasks while BP, HR, total peripheral resistance, and cardiac output (CO) were assessed. Results: After adjustment for traditional risk factors and baseline cardiovascular activity, depression scores were negatively associated with systolic BP, HR, and CO responses to the mental arithmetic task, while anxiety scores were inversely related to the systolic BP response to mental arithmetic. Conclusion: High anxiety or depression scores appear to be associated with blunted cardiac reactions to mental arithmetic (an active coping task), but not to the cold pressor test or speech tasks. Future research should further examine potential mechanisms and longitudinal pathways relating depression and anxiety to cardiovascular reactivity. Clinical trial registration number: TCTR20160208004

Cardiovascular reactivity in young adults with hypertensive and normotensive parents: A gender based comparative study

Introduction: Essential hypertension begins due to mutation of specific genes that contribute to the risk of developing hypertension. Genetic contribution was recognized 25 years ago, now formulated from time to time. Some studies have also proven that the hypertension in father had strong contribution in their individual than mother. The aim of the study is to compare the cardiovascular reactivity in male and female subjects with hypertensive and normotensive parents. Materials and methods: This comparative study was conducted in physiology department of Teerthanker Mahaveer medical college and research center, Moradabad. The research work was initiated after taken the ethical clearance from the ethical committee of the college. Three different stressors: cold pressor task, cycling and videogame were used. Total 120 subjects were taken for the study in which 77 were male and 43 were female. Result: Male subjects of normotensive parents had slightly higher HR rate (mean: 76.73/min) compared to the female subjects (mean: 75/min) with p value >0.05. Female subjects of hypertensive parents had higher HR rate (mean: 82.72/min) compared to the male subjects (mean: 73.95/min) with p value <0.001. Conclusion: Male subjects with normotensive parents had higher resting HR, SBP &DBP than Female subjects with normotensive parents, but the difference was significant only in SBP. Female subjects with hypertensive parents group was showing higher resting HR than male subjects with hypertensive parents group, remains higher after stress also with insignificant difference. Thus, subjects with hypertensive parents showing increased CVR to stress are more likely to develop future hypertension, and the risk is greater for male subjects.

A Prospective Comparative Study Comparing Cardiovascular Reactivity in Obese Young Adult Male and Female Individuals.

Background: Cardiovascular reactivity (CVR) is defined as increase in heart rate (tachycardia) and blood pressure (hypertension) due to stress by the activation of sympathetic nervous system. Methods: Students of 18-25 years of age of various courses at Teerthanker Mahaveer Medical College, Body Mass Index (BMI) > 18 kg/m2 and self-reported teetotallers was enrolled for the study. After recording the basal parameters, all subjects underwent various pressor stimuli and haemodynamic parameters were recorded accordingly. Results: All values dPulse was higher in female (0.87/min) than obese male (0.38/min), dSBP & dDBP was higher in Obese male (1.88mmHg &2.14mmHg) than obese female (1.16mmHg &1.09mmHg) with significant difference. HR showed insignificant difference by all stressors except just after 1min of Videogame. Blood pressure was higher in male subject’s after1min/5min of stress with significant difference after 1min.of CPT/cycling/videogame. This is due to progesterone and due to their large musculature body. Conclusion: Obese male individual showing lower resting pulse rate but higher SBP &DBP than obese female subjects.CVR to stress, result was remains same dPulse was higher in female & the blood pressure was higher in obese male group with insignificant difference except 1min after 1min of VG.

Resposta da pressão arterial ao estresse agudo traumático em urgências ortopédicas / Blood pressure response to acute traumatic stress in orthopedic emergencies

JUSTIFICATIVA E OBJETIVOS: Pacientes vítimas de trauma ortopédico apresentam como resposta ao estresse, elevação transitória da frequência cardíaca e da pressão arterial (PA), fenômenos da reatividade cardiovascular, sendo erroneamente classificados como hipertensos, e medicados como tal. O objetivo deste estudo foi avaliar os pacientes com elevação transitória da PA, bem comoos hipertensos. MÉTODO: Estudo transversal, realizado em hospital de referencia, na cidade de Dourados, MS. A amostra foi de 50 indivíduos, vítimas de trauma ortopédico, com idade ? 18 anos. Foram excluídos os pacientes com período de internação menor que 24h, trauma grave ou instabilidade hemodinâmica. Foram realizadas diariamente, três medidas da PA em um dos membros superiores,com intervalo de um minuto entre as medidas, e a média das duas últimas medidas foi considerada a PA do indivíduo. Para as aferições foi utilizado aparelho de coluna de mercúrio de acordo comas V Diretrizes Brasileiras de Hipertensão. Para o diagnostico de hipertensão o critério foi pressão arterial sistólica (PAS) ? 140 oupressão arterial diastólica (PAD) ? 90 mmHg. As variáveis analisadas foram: idade, sexo, estado civil, raça, escolaridade, diagnóstico prévio de hipertensão arterial sistêmica (HAS), tratamento farmacológico para HAS, comorbidades associadas, PAS e PAD. RESULTADOS: A idade média dos pacientes foi de 31,9 ± 14,7 anos para normotensos, 41,2 ± 17,7 para elevação transitória e 41,0 ± 19,8 para hipertensos. Foram classificados como: em normotensos (50%), elevação transitória (26%) e hipertensos (24%). CONCLUSÃO: A reatividade cardiovascular ao trauma provoca elevação transitória da PA. A sua interpretação correta na urgência tem papel importante no diagnóstico e cuidados da doença hipertensiva.

BACKGROUND AND OBJECTIVES: In response to stress, orthopedic trauma patients present transient elevation in heart rate and blood pressure (BP), cardiovascular reactivity phenomena, being wrongly classified as hypertensive, and treated as such. The aim of this study was to evaluate patients with transient elevation of BP, as well as hypertension. METHOD: Cross-sectional study in reference hospital in the city of Dourados, state of Mato Grosso do Sul (MS). The sample consisted of 50 patients, victims of orthopedic trauma, aged ? 18 years. We excluded patients hospitalized for less than 24 hours, with severe trauma, or hemodynamicaly instable. Three BP measurements were performed daily in either upper limb, with an interval of one minute, and the average of the last two measurements was considered the subject's BP. For the measurements, a mercury column device according to the V Brazilian Guidelines on Hypertension was used. The criterion for diagnosing hypertension was systolic blood pressure (SBP) ? 140 or diastolic blood pressure (DBP) ? 90 mmHg. The variables analyzed were: age, gender, marital status, race, education level, previous diagnosis of systemic hypertension (SH), pharmacological treatment for SH, associated comorbidities, SBP and DBP. RESULTS: The average age of patients was 31.9 ± 14.7 years for normotensives, 41.2 ± 17.7 to transient elevation and 41.0 ± 19.8 for hypertensive patients. They were classified as normotensive (50%), transient elevation (26%) and hypertensive (24%). CONCLUSION: The cardiovascular reactivity to trauma causes transient elevation of blood pressure. The correct interpretation of BP levels in trauma patients has an important role in the diagnosis and care of hypertensive disease.

Effect of gender on the association of adiposity with cardiovascular reactivity in Gujarati Indian adolescents.

Studies have reported that both gender and adiposity influence cardiovascular reactivity amongst adolescents. However, not much is known about the effect of gender on the association of adiposity with cardiovascular reactivity. The current study was conducted to learn how gender affects the association of adiposity with cardiovascular reactivity in the Gujarati Indian adolescents so as to develop preventive strategies for the local population. A cross-sectional study was conducted on 428 (Girls-173, Boys- 255) Gujarati Indian adolescents of age group 16-19 years. Adiposity was assessed in terms of Body Mass Index (BMI), Body Fat Percentage (BF %), Fat Mass (FM), Fat Mass Index (FMI) and Waist Circumference (WC). Percentage Rise in Pulse Rate (%RPR) and Percentage Rise in Diastolic Blood Pressure (%RDBP) during Isometric Handgrip Test were used to assess the cardiovascular reactivity to acute sympathetic stress. Pearson’s correlation coefficient was determined to find the association of adiposity with cardiovascular reactivity. Boys were found to have a significantly larger WC, higher physical fitness and greater %RDBP in comparison to girls while girls had a significantly higher BF% and FMI in comparison to boys. In both boys and girls, BMI, BF%, FMI and WC showed significant positive association with %RDBP with stronger correlationship found in girls. Girls also showed a significant negative correlationship between physical fitness and vascular reactivity. It could thus be concluded that gender affected the association of adiposity with vascular reactivity in Gujarati Indian adolescent such that girls tend to have a larger correlationship between adiposity and vascular reactivity than boys which is most likely due to lower physical fitness.

Family history of hypertension is associated with exaggerated cardiovascular reactivity to mental, but not to physical test.

Aim To investigate whether normotensive young adults with family history of hypertension demonstrate exaggerated cardiovascular responses to both mental and physical stimuli as compared to normotensive young adults without family history of hypertension. Methods Normotensive undergraduate students of normotensive parents (n = 40) and of hypertensive father/ mother/ both (n = 40), aged 20 – 30 years, performed serial subtraction test in a sitting position for three minutes. After taking a rest, subjects performed cold pressor test in ninety seconds. In each test, blood pressure and pulse rate were recorded in pre-test, during test, and post-test using an automated oscillometric device. Changes score rather than absolute scores were analyzed using independent t-test or Mann-Whitney. Results There were no signifi cantly differences in age, body mass index, fasting blood sugar, and plasma creatinine between the two groups. Normotensives of hypertensive parents had signifi cantly higher offi ce systolic blood pressure (108.33+1.6 vs 103.00+1.6 mmHg) and delta change score of cardiovascular reactivity to serial subtraction test (MABP 19.13+1.4 vs 15.5+1.0 mmHg, P= 0.04), but not to cold pressor test (MABP 24.26+1.7 vs 21.74+1.7 mmHg) than those of normotensive parents. Conclusion Normotensive young adults with family history of hypertension demonstrated exaggerated cardiovascular reactivity to mental test but not to physical test. As compared to normotensive young adults without family history of hypertension However, this familial difference in cardiovascular reactivity to mental test is confused with offi ce blood pressure.

Resposta cardiovascular ao Stroop: comparação entre teste computadorizado e verbal / Cardiovascular response to Stroop test: comparison between the computerized and verbal tests

FUNDAMENTO: O teste de Stroop requer que o indivíduo responda a elementos específicos de um estímulo enquanto inibe processos mais automatizados. OBJETIVO: Comparar a reatividade cardiovascular induzida pela versão computadorizada do teste palavra-cor de Stroop - TESTINPACS® com versão tradicional baseada na leitura de palavras impressas. MÉTODOS: A amostra de conveniência foi constituída por 20 mulheres (22,4 ± 4,1 anos). Análises de variância com medidas repetidas foram utilizadas para comparar efeitos principais entre testes (computadorizado, verbal), assim como entre etapas do teste (linha de base, Stroop 1, Stroop 3) das variáveis fisiológicas (pressão arterial, arritmia sinusal respiratória, frequência cardíaca e frequência respiratória). Testes t para amostras pareadas foram utilizados para comparar as médias pressóricas entre o Stroop 3 e a linha de base. Ademais, a magnitude dos efeitos (d') foi estimada a fim avaliar o impacto das diferenças entre as medidas fisiológicas relativas ao Stroop 3 e a linha de base. RESULTADOS: As duas versões do instrumento produziram elevação significativa em frequência cardíaca (p<0,01) e pressão arterial sistólica (p<0,05) quando medidas resultantes do Stroop 3 foram comparadas às de base. Não se verificaram, contudo, diferenças significativas produzidas pelas diferentes versões do teste sobre as demais variáveis investigadas. Estatísticas d' confirmaram a grande magnitude dos efeitos (-1,04 a +1,49) entre as medidas do Stroop 3 e da linha de base. CONCLUSÃO: Conclui-se que a presente versão computadorizada TESTINPACS® do teste de Stroop constitui instrumento útil para induzir reatividade cardiovascular em mulheres.

BACKGROUND: The Stroop test requires the individual to respond to specific elements of a stimulus, whereas inhibiting more automated processes. OBJECTIVE: To compare the cardiovascular reactivity induced by the computerized version of the Stroop word-color test TESTINPACS® with the traditional version based on the reading of printed words. METHODS: The sample of convenience consisted of 20 women (22.4 ± 4.1 years). Analyses of variance with repeated measures were used to compare the main effects between the tests (computerized vs verbal), as well as between phases of the test (baseline, Stroop 1, Stroop 3) on the physiological variables (arterial pressure, respiratory sinus arrhythmia, heart failure and respiratory rate). The t tests for paired samples were used to compare the pressure means between Stroop 3 and baseline. Additionally, the magnitude of the effects (d') was estimated in order to assess the impact of the changes in the physiological measurements between Stroop 3 and the baseline. RESULTS: The two versions of the assessment tool caused significant increase in heart rate (p<0.01) and systolic arterial pressure (p<0.05) when the measurements obtained at the Stroop 3 were compared to that of baseline. However, no significant differences were observed regarding the different versions of the test on the other investigated variables. The d' statistics confirmed the high magnitude of the effects (-1.04 to +1.49) between the measurements from the Stroop 3 and the baseline ones. CONCLUSION: It is concluded that the current computerized version (TESTINPACS TM) of the Stroop test constitutes a useful instrument to induce cardiovascular reactivity in women.