ABSTRACT
Introduction: Both kenaf (Hibiscus cannabinus) and roselle (Hibiscus sabdariffa) belong to the Malvaceae family. Method: In this study, the phytochemical analysis and anti-inflammatory activity of kenaf seed oil (KSO), kenaf seed extract (KSE), roselle seed oil (RSO) and roselle seed extract (RSE) were investigated. Results:The flavonoids content present in the roselle seed oil (RSO), roselle seed extract (RSE), kenaf seed oil (KSO) and kenaf seed extract (KSE) ranged from 52.94±7.31 mg catechin/100g of sample (KSE) to 290.05±12.04 mg catechin/100 g of (RSE); phenolic content ranged from 108.46±6.40mg GAE/ 100g of sample (RSO) to 229.65±7.91 mg GAE/ 100g of sample (RSE); saponin content ranged from 68.14±3.46 mg saponin/ 100 g of sample (KSO) to 98.50±2.44 mg saponin/ 100g of sample (RSE); terpenoid content ranged from 148.76±9.69 mg linaloo1/100g of sample (KSO) to 294.74±16.14 mg linaloo1/100g of sample (RSE); and alkaloid content ranged from 17.40±1.346%/g (KSO) to 46.95±1.792%/g (RSE). The results showed that KSE, RSO and RSE significantly inhibited (p<0.05) inflammation compared to the control. Conclusion: The present study demonstrates that KSE, RSO and RSE exhibit potent anti-inflammatory property and offer potential for use as a therapeutic regiment in managing inflammatory conditions.
ABSTRACT
Effects of ethanolic extract of Desmodium pulchellum Benth. (Fabaceae) barks on alloxan-induced diabetic rats were investigated. In diabetic rats, blood glucose levels were reduced by 18.64 – 34.04 % on consumption of the extracts, with greater effect exhibited by the 1000mg/kg extract whereas in Glibenclamide treated diabetic rats, blood glucose levels were reduced upto 73.55%. The results suggested ethanolic extract of barks may contribute to the reduction of blood glucose levels and can be useful in the management of diabetes. The acute oral toxicity showed that the ethanolic extract of D. pulchellum barks was safe until 4000mg/kg body weight and no macroscopical organ abnormalities were observed in acute oral models. The investigations on Albino (Wistar) rats at dosage of 100, 200 and 400 mg/kg of ethanolic extract of D. pulchellum barks were made for anitiinflammatory action by using carrageenan induced paw edema and cotton pellete granuloma technique. The results of the study suggested significant dose dependent activity of extracts as compared to control group for both acute and chronic inflammation.
ABSTRACT
Ethanolic extract of Sterculia villosa barks were studied for anti-inflammatory and antidiabetic activity. The acute oral toxicity showed that the ethanolic extract of S. villosa barks was safe until 4000mg/kg body weight and no macroscopical organ abnormalities were observed in acute oral models. The investigations on Albino (Wistar) rats at dosage of 100, 200 and 400 mg/kg of ethanolic extract of Sterculia villosa barks were made for aniti-inflammatory action by using carrageenan induced paw edema and cotton pellete granuloma technique. The results of the study suggested significant dose dependent activity of extracts as compared to control group for both acute and chronic inflammation. Ethanolic extract also showed significant antidiabetic activity at dose dependent manner compared to diabetic untreated group.