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Objective:To detect depression in stroke patients and observe its influence on rehabilitation of neurological function and the effect of fluxetine therapy Methods:132 acute stroke patients (78 with infarction, 54 with hemorrhage) were included in the study After inclusion, we did five times of assessments at the end of 2 weeks, 1 month, 3 months, 6 months and 1 year respectively using HAMD assessment to determine whether there had depression or not, as well as SSS (modified Edingburgh-Scandinavian Scoring Scale) for neurological function, ADL (activity of daily living), and self rate depression and anxiety (Zung's self rate depression scale and anxiety scale) Of those with depression, 25 received fluxetine 20mg/d, other 32 with only regular treatment of stroke as control Results:According to results of HAMD, 59 of the 132 had depression (44 7%) The rate of depression had no significant difference between male and female, between those with infarction and with hemorrhage Depression had negative influence on neurological function and activity of daily living Depression had no relation to location, size and unilateral or bilateral of the loci Fluxetine improved depression, neurological function and activity of daily living from 3 months after stroke; its influence on neurological impairment was most significant at 1 year after stroke Conclusion: Post stroke depression is common after cerebral infarction or hemorrhage, it has negative influence on rehabilitation of neurological function and activity of daily living Fluxetine improves both neurological impairments and activity of daily function, as the same time of its improvement of depression
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0.05).Conclusion:It is similar in both incidence rate of depression symptoms and clinical manifestations between ET and PD.Depression symptoms in ET are common,so clinicians should pay attention to it.