1.
Chinese Pharmacological Bulletin
;
(12): 579-584, 2021.
Article
in Chinese
| WPRIM
| ID: wpr-1014401
ABSTRACT
Aim To investigate the effect of compatibility of phellodendron amurense on the pharmacokinetics of mangiferin(MGF) in INS-1 cells, and the distribution of mangiferin in normal and oxidatively damaged INS-1 cells. Methods INS-1 cells were administered in equal doses of mangiferin, anemarrhena and anemarrhena-phellodendron herb pair. LC-MS/MS was used to determine the content of MGF in INS-1 cells. The normal and model groups (INS-1 cells were treated with 140 μmol · L