Quercetin-Loaded Ceria Nanoparticles Induce Autophagy Blockage in Hepatoma Cells / 中国生物化学与分子生物学报

The biosafety of rare earth oxide nanomaterials has attracted more and more attention, and the autophagy response induced by such nanomaterials is also of great significance for cancer treatment. Autophagy plays a dual role in cell survival and death. Quercetin can promote autophagy, and rare earth oxides have been shown to induce different types of autophagy. Dextran-coated cerium oxide nanoparticles-loaded quercetin composite DCQ was synthesized, characterized, and studied for its effects on cell viability, oxidative damage, autophagy and apoptosis in human hepatoma cells HepG2. The results showed that the composite material was more toxic to HepG2 cells, and had no obvious toxic effect on normal cells, human umbilical vein endothelial cells (HUVEC). The composite material was found to induce production of reactive oxygen, block autophagy and promote apoptosis of HepG2 cells. This result shows that this nanocomposite can effectively kill human liver cancer cells, which may provide a new strategy for liver cancer treatment.

Research progress of ceria nanoparticles in the field of radiation / 中国辐射卫生

With the rapid development of nuclear technology in the fields of industry and medicine, the possibility of people suffering from radiation damage has also increased. Radiation injury prevention and treatment drugs are the most effective and direct means for the treatment and protection of radiation injury, but the current radiation injury prevention and treatment drugs have limited effects. Due to the unique valence structure of cerium nanomaterials, it has a variety of enzymatic simulation activities and reproducibility. It shows superior oxidation resistance, powerful free radical scavenging function, and can protect cells from radiation damage. It can be used as an ideal it is a radioprotective agent, and is used in a variety of biological fields. A review of relevant literature shows that the antioxidant properties, high SOD mimicking activity, free radical scavenging ability and radiation resistance of ceria nanoparticles are derived from the mutual conversion of Ce3+/Ce4+ and the formation of oxygen vacancies. This article mainly introduces the basis of anti-radiation activity of ceria nanoparticles, radiation protection effects and the research progress of radiotherapy sensitization, and provides theoretical basis and reference for ceria nanoparticles in the field of radiation direction.