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Objective:To search and summarize the best evidence of aromatherapy in alleviating chemotherapy-related nausea and vomiting in cancer patients, so as to provide reference for nursing staff to implement symptom management.Methods:All evidences on the application of aromatherapy in the relief of chemotherapy-related nausea and vomiting in cancer patients were searched from the guideline collaboration network, professional association websites, and well-known databases at home and abroad from July 2011 to July 2021. The literature quality evaluation tool was used to evaluate the quality of the included literature, and extracted evidence from the literature that met the quality requirements.Results:Ten articles were included at last, including 2 clinical practice guidelines, 1 clinical decision, 2 expert consensus, 1 evidence to summarize, and 1 system evaluation. A total of 11 best evidences of aromatherapy to relieve chemotherapy-related nausea and vomiting were obtained. They were from five aspects: intervention population, aromatherapy practitioners, effectiveness, aromatherapy administration route and adverse reactions.Conclusions:The available evidence indicates that either essential oil aroma therapy or oral aroma therapy has a certain efficacy in alleviating chemotherapy-related nausea and vomiting, and more clinical studies, systematic reviews, and other evidences are still needed to be clarified in the future to promote the normative application of aroma therapy.
ABSTRACT
Objective::To explore the mechanism of Xiao Banxiatang in preventing and treating chemotherapy-induced nausea and vomiting by using network pharmacology. Method::The targets of chemotherapy-related nausea and vomiting were collected by therapeutic target database (TTD), Drugbank database and DisGeNET database. The target genes were normalized by Uniprot database. The traditional Chinese medicine systems pharmacology database and analysis platform (TCMSP) was selected according to oral bioavailabilityc (OB) ≥ 30%, drug-likeness (DL) ≥ 0.14 and the literature research. The active constituents of pinellia ternata and ginger were collected through the PubChem database, the ALOGPS2.1 database and the Swiss Target Prediction database, and the target of ginger was collected and standardized through the Uniprot database, the molecular inverse docking of the important component 6-gingerol was carried out through the DRAR-CPI database, gene ontology (GO) analysis and kyoto encyclopedia of genes and genomes (KEGG) pathway analysis were performed through DAVID 6.8 database, and relationship diagrams were drawn by Cytoscape 3.2.1 software and network topology parameters were analyzed, GO and KEGG bubble maps were drawn by ImageGP tool. Result::A total of 148 targets for chemotherapeutic nausea and vomiting, and 27 active ingredients of Xiao Banxiatang were collected, including 22 associated with chemotherapeutic nausea and vomiting, 38 control targets, 67 biological processes based on GO analysis, 11 cell components, 18 molecular functions, 21 KEGG pathways, involving cyclic Adenosine monophosphate (cAMP) signaling pathway, calcium signaling pathway, Rap1 signaling pathway. Conclusion::Based on network pharmacology, chemotherapy-related nausea and vomiting and Xiao Banxiatang were analyzed to provide ideas for the prevention and treatment of chemotherapy-induced nausea and vomiting.