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Objective To investigate the effect of pidotimod granules and Carboxymethyl starch sodium solution in treating children with recurrent respiratory tract infection curative effect and effect on immune function of children.Methods 128 cases of children with recurrent respiratory tract infection in our hospital from June 2013 to June 2016 were selected and divided into treatment group and control group with 64 cases in each group. Children in the control group were treated with Carboxymethyl starch sodium solution, the treatment group was given pidotimod granules on the basis of the control group.Two groups of children were treated for 12 weeks.The therapeutic effects of the two groups were compared, the changes of immune function before and after treatment, cough, fever, lung rales disappear time, and the incidence of adverse reactions.Results The total effective rate of the treatment group (90.62%) was higher than the control group (75.00%), the difference was statistically significant (P<0.05), the levels of IgA, IgM and IgG increased after treatment in both groups, the levels of IgA, IgM and IgG in the treatment group were higher than those in the control group, the difference was statistically significant (P<0.05), the levels of CD3 +, CD4 +and CD4 +/CD8 +increased after treatment in both groups, and the levels of CD3 +, CD4 +and CD4 +/CD8 +in the treatment group were higher than those in the control group, the difference was statistically significant (P<0.05), the treatment group in children with cough, fever, pulmonary rales disappeared faster than the control group, the difference was statistically significant (P <0.05), two groups were no obvious adverse reactions.Conclusion Pidotimod granules combined with carboxymethyl starch sodium solution in treating children with recurrent respiratory tract infections is effective, and could significantly improve the immune function of children.
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Objective To observe the curative efficacy of adjuvant therapy of Yupingfeng particles in bronchial asthma children with recurrent respiratory tract infection (RRTI) and its influence on humoral immunity function. Methods 98 patients of bronchial asthma children with RRTI meeting the inclusion criteria were collected as observation objects. Retrospectively analyzing their clinical materials, those patients were divided into the control group (n=42) and the observation group (n=56) according to therapeutic schemes. The control group was given conventional treatments. Besides that, the observation group was given adjuvant therapy of Yupingfeng particles. Then, curative efficacy, humoral immunity related indices and adverse reactions were compared between the two groups. Results As to curative efficacy related indices after six-month follow-up, the observation group had less times of respiratory tract infection [(2.53±0.94) vs.(4.06±1.38)times], shorter asthma wheeling time and shorter time of using antibiotics [(0.67±0.12) vs. (1.74±0.52) d, (8.29±2.15) vs. (15.37±3.42) d] with all statistical differences (all P<0.05). After treatment, in comparison with the control group, levels of humoral immunity indices of serum IgA, IgG were statistically higher in the observation group [(0.93±0.17) vs. (0.49±0.11) g/L; (7.52±0.78) vs. (6.35±0.70) g/L, both P<0.05]. During the treatment, there's no case of severe adverse reactions. And the incidences of adverse reactions in the control group and the observation group were statistically same (4.8% vs. 8.9%). Conclusion Adjuvant therapy of Yupingfeng particles has well curative efficacy in bronchial asthma children with RRTI. And it can reduce occurrence of respiratory tract infection and promote humoral immunity function with minor adverse reactions.
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Objective To observe the curative efficacy of adjuvant therapy of Yupingfeng particles in bronchial asthma children with recurrent respiratory tract infection (RRTI) and its influence on humoral immunity function. Methods 98 patients of bronchial asthma children with RRTI meeting the inclusion criteria were collected as observation objects. Retrospectively analyzing their clinical materials, those patients were divided into the control group (n=42) and the observation group (n=56) according to therapeutic schemes. The control group was given conventional treatments. Besides that, the observation group was given adjuvant therapy of Yupingfeng particles. Then, curative efficacy, humoral immunity related indices and adverse reactions were compared between the two groups. Results As to curative efficacy related indices after six-month follow-up, the observation group had less times of respiratory tract infection [(2.53±0.94) vs.(4.06±1.38)times], shorter asthma wheeling time and shorter time of using antibiotics [(0.67±0.12) vs. (1.74±0.52) d, (8.29±2.15) vs. (15.37±3.42) d] with all statistical differences (all P<0.05). After treatment, in comparison with the control group, levels of humoral immunity indices of serum IgA, IgG were statistically higher in the observation group [(0.93±0.17) vs. (0.49±0.11) g/L; (7.52±0.78) vs. (6.35±0.70) g/L, both P<0.05]. During the treatment, there's no case of severe adverse reactions. And the incidences of adverse reactions in the control group and the observation group were statistically same (4.8% vs. 8.9%). Conclusion Adjuvant therapy of Yupingfeng particles has well curative efficacy in bronchial asthma children with RRTI. And it can reduce occurrence of respiratory tract infection and promote humoral immunity function with minor adverse reactions.
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ObjectiveTo evaluate clinical efficacy ofYupingfeng Granules combined with western medicine for children with recurrent respiratory tract infection (RRTI).Methods CNKI, VIP, WANFANG DATA, SinoMed, PubMed, Embase, and Cochrane Library were searched for the randomized controlled trials (RCTs) that investigated the clinical and immune effects ofYupingfeng Granules in children with RRTI from inception to October 2015. Two researchers independently screened studies according to the inclusion and exclusion criteria, extracted data and evaluated the methodological quality of included studies. Then Meta analysis was performed through the software RevMan 5.3.Results A total of 8 articles involving 550 patients were included. The results of Meta analysis showed effective rate ofYupingfeng Granules combined with western medicine for children with RRTI [OR=4.16, 95%CI (2.49, 6.95),P0.05). ConclusionYupingfeng Granules combined with western medicine can improve effective rate, antibody level and T-cell level in the treatment of children with RRTI. The overall clinical efficacy is better than single western medicine treatment. However, RCTs with large samples, multiple centers and high quality are needed for further verification.