Choroidal neovascularization associated with coloboma of the choroid: A series of three cases.

Choroidal neovascularization (CNV) is a rare complication associated with coloboma of the choroid. We describe three cases of coloboma choroid where there was loss of vision due to CNV development at the edge of the coloboma. One was managed by photodynamic therapy alone and two were managed by a combination of reduced fluence PDT and intravitreal bevacizumab. Significantly we noted that one treatment session was sufficient to achieve regression of the CNV and improvement in visual acuity.

The Development of Recurrent Choroidal Neovascularization in a Patient with Choroidal Coloboma

We report a case of recurrent choroidal neovascularization (CNV) in an eye with chorioretinal coloboma. A 36-year-old woman presented complaining of decreased visual acuity (VA) in her left eye. Best corrected visual acuity (BCVA) was 20/200 and iris coloboma was observed. Funduscopy and fluorescein angiography (FA) showed CNV in the superior extrafoveal region with chorioretinal coloboma reaching just inferior to the optic disc. No other cause for CNV was observed except for the chorioretinal coloboma. BCVA improved to 20/30 after laser photocoagulation. She revisited our clinic for deteriorating VA (20/400) in the same eye 3 years after treatment. Funduscopy and FA demonstrated recurrent CNV with subfoveal hemorrhage. Photodynamic therapy (PDT) was followed by three consecutive intravitreal bevacizumab injections (IVB) for the subfoveally-located CNV. However, the CNV persisted with the appearance of a fresh subretinal hemorrhage. Additional PDT was combined with IVB on the same day 6 months after the initial PDT. The CNV regressed 3 months after treatment and has not recurred as of 8 months after the last treatment. The patient's BCVA improved to 20/60. This case suggests that PDT combined with IVB can be an alternative treatment for the management of recurrent CNV after laser photocoagulation in eyes with chorioretinal coloboma.

Two Cases of Choroidal Coloboma Associated Retinal Detachment in Infant

Choroidal coloblma, which is uncommon but not rare. occurs in areas in which both the neurosensory and the retinal pigment epithelium precursors fail to become confluent. Retinal detachment usually occurs due to breaks in the colobomatous area and has been noted in nearly 40% of the patients with choroidal ccloboma. Retinal detachment may be associated with a coloboma of the choroid soon after birth and can present a diagnostic dilemma. We experienced the choroidal coloboma associated with retinal detachment in an 18-day-old premature baby and a 40-day-old infant, one of which had multiple congenital anomalies. We present our two cases with a brief review of the literature related to choroidal coloboma.

Two Cases of Choroidal Coloboma Associated Retinal Detachment in Infant

Choroidal coloblma, which is uncommon but not rare. occurs in areas in which both the neurosensory and the retinal pigment epithelium precursors fail to become confluent. Retinal detachment usually occurs due to breaks in the colobomatous area and has been noted in nearly 40% of the patients with choroidal ccloboma. Retinal detachment may be associated with a coloboma of the choroid soon after birth and can present a diagnostic dilemma. We experienced the choroidal coloboma associated with retinal detachment in an 18-day-old premature baby and a 40-day-old infant, one of which had multiple congenital anomalies. We present our two cases with a brief review of the literature related to choroidal coloboma.