ABSTRACT
Botulinum toxin type A (BTA) injection, marketed as BOTOX, is commonly used as a treatment for a variety of clinical indications and is widely viewed as safe, effective and largely devoid of serious side effects. Anaphylactic reactions to BTA are typically unheard of in the scientific literature. BOTOX is approved by the Food and Drug Administration for the treatment of cervical dystonia and prophylaxis for chronic migraines. This case report documents a unique instance of allergic reaction to BTA in a 29-year-old woman with cervicogenic headache and cervical dystonia who reported immediate flushing, light-headedness and nausea after receiving BTA injections.
A injeção de toxina botulínica tipo A (BTA), comercializada como BOTOX, é comumente usada como tratamento para uma variedade de indicações clínicas e é amplamente considerada segura, eficaz e amplamente desprovida de efeitos colaterais graves. As reações anafiláticas ao BTA são normalmente inéditas na literatura científica. BOTOX é aprovado pela Food and Drug Administration para o tratamento de distonia cervical e profilaxia de enxaquecas crônicas. Este relato de caso documenta um caso único de reação alérgica ao BTA em uma mulher de 29 anos com dor de cabeça cervicogênica e distonia cervical que relatou rubor imediato, tontura e náusea após receber injeções de BTA.
ABSTRACT
Affecting 1-2% of the world's population and representing up to 40% of patients in specialist headache services, medication overuse headache remains a challenge. Starting with the need to make professionals aware since basic care, through patient education and ending with adequate (and successful) management, there is still much to be done. This literature review seeks to draw attention not only to the importance of recognizing the condition, but mainly to bring out the latest in the best management of patients who suffer from pain more than 14 days a month and who still see analgesics as the only way to manage their pain.
Afectando 1-2% da população mundial e representando até 40% dos pacientes em serviços especializados em cefaleias, a cefaleia por uso excessivo de medicamentos continua a ser um desafio. Começando pela necessidade de conscientizar os profissionais desde a atenção básica, passando pela educação do paciente e terminando no manejo adequado (e bem sucedido), ainda há muito a ser feito. Esta revisão de literatura busca chamar a atenção não apenas para a importância do reconhecimento da condição, mas principalmente trazer à tona o que há de mais moderno no melhor manejo de pacientes que sofrem com dores por mais de 14 dias por mês e que ainda veem os analgésicos como a única forma de administrar sua dor.
Subject(s)
Humans , Child , Adolescent , AdultABSTRACT
Introduction: Chronic headache is a common health problem in general medical practice and there is increasing demand of CT scan from specialist as well as non-specialist doctors to refer patients for CT head scan. Patients and methods: The present study was done on 2800 CT head scans of patients with problem of chronic headache. While patients in Group 1 (n=1900) had only chronic headache without any neurological findings, Group B comprised of cases (n=900) referred by specialist doctors after neurological examination. CT scan was done by trained technicians and contrast was injected where necessary. Results: Present study showed majority of patients in both group 1 and group 2 (90% and 87.7% respectively) had normal CT findings or insignificant findings. However, difference was not significant in both groups when significant findings (10.0% Gr. A and 12.2% Group B) were compared. Discussion: Our findings are consistent with other studies concluding that routine CT scan may not provide clinically useful information in chronic headache.
ABSTRACT
Botulinum toxin (BoNT) injections have been used not only in the field of cosmetic surgery such as forehead and eye wrinkle treatment but also in the treatment of chronic migraine, dystonia, spasticity, temporomandibular disorders (TMD). BoNT injections are the only approved therapies to date for prophylactic treatment of chronic migraine patients. Unlike the previously known paralysis of motor neurons, the mechanism of action for migraine is to block the release of non-cholinergic neurotransmitters such as substance P, CGRP, and glutamate, which are associated with peripheral sensitization and neurogenic inflammation in the sensory nerve, it is hypothesized that the signal is blocked. This review focuses on the analgesic effects of BoNT and suggests the direction for the development of injection methods for chronic migraine patients.
Subject(s)
Humans , Botulinum Toxins , Dystonia , Forehead , Glutamic Acid , Headache Disorders , Migraine Disorders , Motor Neurons , Muscle Spasticity , Neurogenic Inflammation , Neurotransmitter Agents , Paralysis , Substance P , Surgery, Plastic , Temporal Lobe , Temporomandibular Joint DisordersABSTRACT
Introducción: la cefalea tipo tensión es la forma más común de dolor de cabeza y su forma crónica una de lasmás difíciles de tratar, causa gran discapacidad a pacientes y representa enormes costos socioeconómicos, estárelacionada con factores de tensión emocional y muscular. Las propuestas terapéuticas con las que se cuentaincluyen AINE, fisioterapia, infiltraciones con toxina botulínica en músculos pericraneales.Objetivo: evaluar la efectividad en el tratamiento de la cefalea crónica tipo tensión con infiltración intramuscularcon betametasona, un esteroide de depósito más lidocaína al 1%, en puntos de tensión muscular aniveles suboccipital, paraespinales cervicales y trapecio, acompañados de fisioterapia y un proceso educativoa pacientes y familiares.Materiales y métodos: estudio retrospectivo, en el que se midió la efectividad del tratamiento utilizandola escala visual análoga (EVA). Los datos fueron analizados en el programa SPSS por medio de porcentajes,frecuencias y proporciones.Resultados: de un total de 138 casos de cefalea crónica diaria tipo tensión, con edad promedio 51 años, 76,8%sexo femenino, 21% se asocia a trastorno ansioso; 8,7% a sensación vertiginosa y 8,7% síntomas depresivos;8% insomnio; 78,2% de los pacientes refirieron mejoría con el tratamiento propuesto y de estos, 85,5% delos casos se cuantificaron según la EVA, 66,8% presentaron mejoría entre 7 y 10 puntos; el mayor porcentajeestuvo asintomático durante tres meses, 22,5% libres de crisis durante el seguimiento total de siete meses y58,7% reincidieron.Conclusión: se evidencia que la combinación de infiltraciones intramusculares con betametasona más lidocaínay fisioterapia y un proceso de educación del personal médico a pacientes y familiares es un tratamiento eficaz, sinefectos adversos, en el manejo de la cefalea crónica tipo tensión, considerada una de las más difíciles de tratar.
Introduction: the tension-type headache is the most common form of headache and chronic one of the most difficult to treat form, causes severe disability to patients and enormous socioeconomic costs is related to emotional stress factors and / or muscle. Therapeutic proposals, which are considered, include NSAIDs, physical therapy, injections of botulinum toxin in pericraneal muscles.Objetives: to evaluate the effectiveness in the treatment of chronic tension-type headache with intramuscular infiltration with steroid betamethasone one deposit plus 1% lidocaine at points of muscle tension level sub-occipital, cervical paraspinal and trapezius, accompanied by physiotherapy, more an educational process to patients and families.Materials and methods: retrospective study where treatment effectiveness was measured using the Visual Analogue Scale (VAS). Data were analyzed in SPSS using percentages, frequencies and proportions.Results: total 138 cases of chronic daily headache tension type, mean age 51 years, 76.8% female, 21% is associated with anxiety disorder, 8.7% giddy feeling and 8.7% depressive symptoms, 8% type insomnia sleep disorders. 78.2% of patients reported improvement with the proposed treatment, of these, 85.5% of cases were quantified according to VAS, 66.8% showed improvement between 7 and 10 points; the highest percentage was asymptomatic for 3 months, 22.5% seizure-free for the total up of 7 months, 58.7% relapsed.Conclusion: it is evident that the combination of intramuscular injections of lidocaine plus Betamethasone more Physiotherapy and a process of education of medical staff to patients and families, is an effective treatment without adverse effects in the management of chronic tension headache, considered one of the most difficult to treat.
Subject(s)
Humans , Education , Headache Disorders , Physical Therapy Specialty , SteroidsABSTRACT
Isolated sphenoid sinusitis is a rare disease in children, and its symptoms are often nonspecific and confusing. Rarely, severe headache can be the first or only symptom of isolated sphenoid sinusitis. New daily persistent headache (NDPH) is a form of chronic daily headache that may have features of both migraines and tension-type headaches. NDPH is difficult to diagnose and requires a multifaceted approach. Here, we report on a 10-year-old boy and an 11-year-old girl who both presented with typical NDPH symptoms. These patients had no nasal symptoms or signs of infection. Neither nonsteroidal anti-inflammatory drugs nor topiramate had any effect on the headaches. Their neurological and ophthalmological examinations were normal. The results of routine blood work, including thyroid function tests, inflammatory markers, complete blood count, tests for viral infection, and a metabolic panel, were normal. A brain magnetic resonance imaging scan showed isolated sphenoid sinusitis. Both patients' symptoms resolved completely after approximately 1 month of oral antibiotics for sinusitis.
Subject(s)
Child , Female , Humans , Male , Anti-Bacterial Agents , Blood Cell Count , Brain , Headache Disorders , Headache , Magnetic Resonance Imaging , Migraine Disorders , Rare Diseases , Sinusitis , Sphenoid Sinus , Sphenoid Sinusitis , Tension-Type Headache , Thyroid Function TestsABSTRACT
We report the case of a 34-year-old man who was initially diagnosed with a tension-type headache after complaining of a headache and nausea. His headache worsened in severity and it was exacerbated on standing in the upright position. The patient was admitted to the hospital on suspicion of spontaneous low cerebrospinal fluid (CSF) pressure headache. Gadolinium-enhanced brain magnetic resonance imaging (MRI) revealed diffuse pachymeningeal enhancement, brain sagging, cerebellar tonsillar herniation, brainstem descent and a subdural hematoma. Successful emergency surgery was undertaken.<br>Spontaneous low CSF pressure headache syndrome is characterized by orthostatic headache, and if such a headache worsens, clinicians should consider a subdural hematoma, a life-threatening complication of this unusual disorder.
ABSTRACT
A terapia cognitivo-comportamental (TCC) é a abordagem psicoterápica mais pesquisada atualmente. Seus fundamentos procuram identificar pensamentos e comportamentos inadequados ou disfuncionais automáticos. Ajuda o paciente a desenvolver habilidades e empregar as técnicas cognitivas para rebater as crenças que destroem sua aceitação da responsabilidade no emprego de técnicas de enfrentamento e autogerenciamento da dor. Também são administradas técnicas de relaxamento para alívio de alguns sintomas da dor crônica.
Subject(s)
Chronic Pain , Therapeutics , Headache DisordersABSTRACT
Reitakutsukito, a Kampo formulation which is described in the textbook <i>Ranhitsu-Hizou</i>, has been well known as a suitable formulation for sinusitis related signs and symptoms.<br>We reported previously three cases, i.e. chronic headache, bronchial asthma and bronchial amyloidosis with sinusitis, successfully treated with this formulation. Here we report on a clinical trial of reitakutsukito for 5 cases in which the chief complaints were pre-menstrual disorder, chronic headache, anorexia, finger dysesthe sia and chronic cough accompanied with sinusitis. We attempted to make clear the <i>sho </i>for this Kampo formulation by means of administering this formulation alone, or with concomitant use of supportive formulations.
ABSTRACT
OBJETIVE: To evaluate the influence of the periodontal disease (PD), a chronic infection, in patients with chronic craniofacial pain complaints. METHOD: Twenty patients with chronic craniofacial pain and PD (CFP group) and 20 patients with PD (PD group) were assessed before and after periodontal treatment (baseline, 30 and 180 days after treatment). The paramenters evaluated were: plaque index, bleeding index, clinical probe insertion, Visual Analogic Scale (VAS) for pain intensity and Numerical Rating Scale (NRS) and Verbal Rating Scale (VRS) for the "chief complaint". RESULTS: After 180 days PD was controlled in both groups (p<0.001); the VAS decreased in CFP group (p<0.001); "chief complaint" improved (p=0.005 and p=0.027, respectively in CFP and PD group). VRS showed improvement between the groups in 30 (p=0.004) and 180 days (p=0.001). CONCLUSION: These results suggest a possible influence of periodontal disease, as a comorbidity, in refractory craniofacial pain patients and in their pain levels.
OBJETIVO: Avaliar a influência da doença periodontal (DP) em pacientes com queixas de dores crônicas crânio-faciais. MÉTODO: Vinte pacientes com dor crônica crânio-facial e DP (CFP group) e 20 pacientes com DP (PD group) foram avaliados antes e depois do tratamento periodontal (baseline, 30 e 180 dias). Avaliações: índice de placa, índice de sangramento gingival, inserção clínica de bolsa, Escala Visual Analógica (VAS) para a dor, Escalas Numérica (NRS) e Verbal (VRS) para as "queixas principais". RESULTADOS: Após 180 dias a DP foi controlada em ambos os grupos (p<0,001); a VAS reduziu no CFP group (p<0,001); a "queixa principal" melhorou (p=0,005 e p=0,027, respectivamente nos grupos CFP e PD). A VRS mostrou diferença entre os grupos em 30 (p=0,004) e 180 dias (p=0,001). CONCLUSÕES: Estes resultados sugerem a provável influência da doença periodontal, como morbidade associada, nos níveis de dor de pacientes com dores crônicas crânio-faciais.
Subject(s)
Adult , Aged , Female , Humans , Male , Middle Aged , Facial Pain/etiology , Periodontal Diseases/complications , Chronic Disease , Pain Measurement , Periodontal IndexABSTRACT
La migraña es quizás el motivo más frecuente de consulta al neurólogo. Su prevalencia es más alta en el sexo femenino, entre la segunda y la cuarta décadas, que es la época de mayor productividad. El dolor en la migraña por lo general es incapacitante, por lo que tiene un gran impacto en la calidad de vida; produce ausentismo laboral y escolar, disminuye el rendimiento, e interfiere con las relaciones familiares. Es necesario hacer un mayor énfasis en la migraña en los estudios de pregrado en medicina, para capacitar a los médicos generales en el diagnóstico y tratamiento de este trastorno. Existen instrumentos para medir en el consultorio el impacto de la migraña en la vida de los pacientes, de los cuales el más importante es el cuestionario MIDAS.
Migraine is perhaps the most frequent reason for consulting the neurologist. Its prevalence is higher in women between the second and fourth decades, which is the period of greatest productivity. The pain in migraine is usually disabling, and for this reason it has a big impact on the quality of life; it produces labor and school absenteeism, and it interferes with family relationships. There is a need for greater emphasis on migraine in undergraduate studies in medicine, to train the general practitioners in diagnosing and treating this disorder. There are many instruments to measure the impact of migraine in the life of the patients, such as MIDAS questionaire.
Subject(s)
Humans , Neurology , Migraine Disorders , Headache DisordersABSTRACT
The source of reitakutsukito, which has been described in only one case, is the text “Ranshitsu-hizo.” We recently experienced a 65-year old male suffering from refractory chronic headache for forty years, and a 38-year old female suffering from bronchial asthma resistant to tokishigyakukagoshuyushokyoto, whose symptoms were successfully treated with reitakutsukito by adding shin'i which has the action of dispersing pathogenic wind factor and opening orifice. Although reduction of underlying disease was not obtained, we also experienced clear improvement of oxygen saturation peripherally, and the subjective symptoms of a 40-year old male suffering from bronchial amyloidosis with reitakutsukitokashin'i. We report these three cases including documented considerations.
Subject(s)
Asthma , AmyloidosisABSTRACT
A cefaléia crônica diária (CCD) compreende quadros de dor de cabeça com duração superior a 15 dias ao mês por, pelo menos, três meses. A CCD não deve ser considerada uma entidade homogênea, pois engloba uma gama diversa de cefaléias primárias e secundárias (ou sintomáticas). Migrânea crônica, cefaléia do tipo tensional crônica e cefaléia por abuso de medicamentos são os diagnósticos mais freqüentes. Neste artigo serão abordados aspectos clínicos e terapêuticos relacionados às causas mais comuns de CCD.
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The purpose of this study was to reevaluate the sho of goshuyuto, which has been established in an unscientific manner, and to create a new concept of the sho of goshuyuto. Eighty-four patients suffering from chronic headache were instructed to orally consume 7.5g. day of a spray-dried powder of goshuyuto (TJ-31) for 4 weeks. Before consuming the TJ-31, all subjects underwent Kampo examinations that were based on 43 diagnostic items. After the 4-week period of medication, all the subjects were classified as either responders or nonresponders. After excluding insignificant items from the 43 diagnostic items, discriminant analysis, which discriminated between responders and nonresponders, was conducted. Of the 80 subjects who completed the trial period, 57 were judged to be responders and 23 to be nonresponders. “Cold feet,” “fluid and gas retention in the stomach,” “kyokyo-kuman,” “tenderness at side of navel,” and “pulsation at abdomen” were selected by stepwise selection. The results of the discriminant analysis using these 5 items suggest that 28 subjects were misclassified and that the misclassification rate was 35%. Of the actual 23 nonresponders, 20 were accurately discriminated as nonresponders. The 5 selected items are suggested to be more useful in selecting the nonresponders than the responders. In conclusion, the empirically established sho of goshuyuto seemed to not be abele to completely explain the indication of goshuyuto. However, the inclusion of “tenderness at side of navel” and “pulsation at abdomen,” as new components comprising the sho of goshuyuto, may facilitate a more accurate indication of goshuyuto.
Subject(s)
Data Interpretation, Statistical , Discriminant Analysis , AbdomenABSTRACT
Yokukansankachimpihange has been applied to practical use for some indications such as irritability, excitability, anxiety and insomnia. We report 6 cases of chronic headache patients (tension-type headache [1], migraine [2] and mixed-type headache [3]) with the significant pulsation at pit of stomach and navel, who were successfully treated with Yoku-kan-san-ka-chimpi-hange for prophylaxis. These findings suggest that Yokukansankachimpihange might be useful for not only tension-type headache but also migraine and mixed-type headache.
Subject(s)
Headache , Disease Prevention , Headache Disorders , Migraine DisordersABSTRACT
PURPOSE: This study was undertaken to determine the incidence and the meaning of epileptiform discharges accompanied by chronic recurrent headaches. METHODS: We selected 449 cases of children who visited Dong-A University Hospital because of recurrent headaches from January 1999 to July 2005. The headaches were classified by the criteria established by the International Headache Research Committee in 2004. The electroencephalography was performed in 336 cases and 36 cases who showed epileptiform discharges were selected. We studied the characteristics of epileptiform discharges, MRI findings and the relationship with epilepsy. RESULTS: The incidence of interictal epileptiform discharges(ILEDs) of the patients with chronic headaches was 10.7%, which was higher than that in a normal population. In the location of ILEDs, focal areas(9.2%) were more common than general areas(1.5%). The incidence of the ILEDs was different according to the types of headaches(P<0.01). The focal ILEDs were concentrated at the central temporal areas. The most common type of ILEDs was frequent epileptiform discharges(63.9%). For the wave forms of ILEDs, focal spike activities were 83.3%, and bursts of slow waves mixed with spikes were 13.9%. Among the 36 cases that showed the ILEDs, 2 cases were associated with epilepsy and another 2 with AV malformation on the MRI images. CONCLUSION: The ILEDs of the patients with chronic recurrent headaches mainly occurred in the central temporal areas as focal spike wave forms, which shows a benign course. Because a few cases can accompany epilepsy and brain abnormalities, close observation and follow-up tests are needed.
Subject(s)
Child , Humans , Brain , Electroencephalography , Epilepsy , Follow-Up Studies , Headache Disorders , Headache , Incidence , Magnetic Resonance ImagingABSTRACT
BACKGROUND: Chronic headache (CH) constitutes a significant public health problem, impacting on both the individual sufferer and society. Patients with CH, unresponsive to drug therapy or nerve block, suffer considerable disability due to the frequency and severity of attacks; therefore, they should be considered for novel therapy. Botulinum toxin type A (BoNT-A) has shown significant promise in the management of CH. In this paper, we review recent evidence on the efficacy of BoNT-A, and also report our experience with this treatment in CH patients. METHODS: BoNT-A was used to treat 69 CH patients, including 47 in a chronic migraine group and 22 in a non-migraine CH group, who showed therapy-resistance to palliative drug or nerve block. We investigated the demography, dosage and site of BoNT-A injection, and used a visual analogue scale (VAS) for pain and the degree of satisfaction. The data were analyzed using t-tests and a Friedman repeated measures analysis of variance on ranks. RESULTS: Significant decreases in the VAS for pain were found in both the chronic migraine and non-migraine CH groups, from 2, 4 and 12 weeks and from 4 and 12 weeks, respectively, after BoNT-A administration (P < 0.05). The chronic migraine group showed significantly lower VAS scores for pain than the non-migraine CH group from 2, 4 and 12 weeks after the BoNT-A administration (P < 0.05). Twenty eight patients (59.2%) in the chronic migraine group and eight (36.4%) in the non-migraine CH were satisfied with the BoNT-A treatment. CONCLUSIONS: This clinical study revealed that the use of BoNT-A demonstrated efficacy for CH patients resistant to drug therapy or nerve block. Moreover, BoNT-A proved itself more effective in the chronic migraine than non-migraine CH group.
Subject(s)
Humans , Botulinum Toxins , Botulinum Toxins, Type A , Demography , Drug Therapy , Headache Disorders , Migraine Disorders , Nerve Block , Public HealthABSTRACT
OBJECTIVES: This study aimed to examine the effect of biofeedback treatment on the clinical symptoms and stress responses in chronic headache patients. METHODS : We recruited 18 chronic headache patients who were treated with 8 sessions of biofeedback treatment and 18 age and sex-matched control headache patients. All subjects consisted of patients with chronic tension headache and migraine headache. Stress responses were measured using Symptoms of stress (SOS) inventory and all subjects performed Beck depression inventory (BDI), Spielberger state anxiety inventory (STAIS), and visual analogue scale (VAS). Biofeedback physiological variables including frontal and forearm EMG, electrodermal response (EDR) and skin temperature at pre-and post-treatment were also measured in all subjects. RESULTS : Compared with control patients, patients on biofeedback treatment showed significant reduction in scores of STAIS (t=3.705, p<.001), and VAS (t=3.392, p=.001) as well as SOS subscales;peripheral manifestations (t=1.788, p=.042), habitual patterns (t=2.008, p=.027), depression (t=2.081, p=.023), anxiety (t=1.990, p=.028), and total score (t=2.045, p=.025). There was a significant increase of skin temperature (t=-1.835, p=.038) only in the biofeedback treatment group. CONCLUSION : These results suggest that biofeedback treatment may be effective in relieving chronic headache by reducing psychological and physiological stress responses.
Subject(s)
Humans , Anxiety , Biofeedback, Psychology , Depression , Forearm , Galvanic Skin Response , Headache , Headache Disorders , Migraine Disorders , Relaxation , Skin Temperature , Stress, Physiological , Tension-Type HeadacheABSTRACT
The administration of Bukuryo-shigyaku-to has been effective in five cases of chronic headache. All five patients visited our department because of unsatisfactory results using Western medicine. They suffered from severe migraines with restlessness, and they were treated effectively with Bukuryo-shigyaku-to. In four of all cases (cases 1-4), symptoms and signs related to coldness were obvious, and especially cases 1 and 3 complained about undesirable coldness on their backs. It is suggested that Bukuryo-shigyaku-to can be useful against severe migraine with restlessness caused by exposure to strong coldness. Case 5 was initially thought to have a status of heat and excess, but the effect of Bukuryo-shigyaku-to revealed the existence of cold and deficiency. Case 5 emphasizes the importance of being aware of the possibility of hidden coldness and deficiency, and that Bukuryo-shigyaku-to can be useful in such a case.
ABSTRACT
A total of 20 chronic headache cases in which other Kampo medicines were ineffective or hardly effective were treated with Kumi-binro-to extract, and the effect of this medicine was investigated.<br>At the start of administration, we investigated the following items: any deficiency or excess, presence or absence of stagnation of vital energy (facial erythema, ophthalmologic injection, bitter taste in the mouth, etc.) and disease caused by contaminated water (tendency of edema, sound of fluctuating liquid in the region of the stomach, decreased urine volume) as well as the presence or absence of grasping pain (pressure pain) in the gastrocnemius muscle which is a characteristic symptom as a target of this drug. The efficacy of Kumi-binro-to was assessed by a pain score after weeks from the start of administration.<br>Kumi-binro-to was markedly effective in 5 cases, effective in 11 cases and ineffective in 4 cases, indicating that the ratio of markedly effective and effective cases accounted for 80% of the patients treated. There was no adverse reaction. When the characteristics of 16 cases assessed as markedly effective or effective were investigated, disease caused by contaminated water and stagnation of vital energy was observed in 13 and 14 of the 16 cases respectively. The grasping pain in the gastrocnemius muscle that is a characteristic target of this drug was noted in only one case.<br>The above result suggests that Kumi-binro-to promotes diuresis to eliminate wetness-evil and regulates vital energy, and is effective against chronic headache, especially when the disease caused by contaminated water is accompanied with stagnation of vital energy.