ABSTRACT
Objective To investigate the effect of two kinds of permeation enhancers,azone and clove bud oil,on transdermal permeation of Shuxiong cataplasm. Methods Cataplasm containing azone and clove bud oil,at different concentrations were prepared,with ferulic acid as the index,the role of enhancing permeation of azone and clove bud oil for the main active component were studied by in vitro permeation experiments. Results Both azone and clove bud oil at different concentrations could increase permeation. Clove bud oil was better than azone and the best concentration of Clove bud oil is 3%. Meanwhile,the permeation enhancing multiple of clove bud oil group was the highest which was 3.68. Conclusion With the cumulative permeation quantity of ferulic acid as the index,3% clove bud oil is more suitable to act as a permeation enhancer of Shuxiong cataplasm.
ABSTRACT
Volatile oil from the clove bud was extracted by petroleum ether using Soxhlet Extractor.The acaricidal activity was examined using direct contact and vapour phase toxicity bioassays.In a filter paper contact toxicity bio-assay,at 2.5 h after treatment,clove bud oil at a dose of 12.20 ?g/cm2 killed all dust mites.As judged by 24-h LD50 values,potent fumigant action was observed with clove bud oil(12.20 ?g/cm2),showing an adequate acaricidal activity against indoor Dermatophagoides farinae.