ABSTRACT
Objective To compare the differences of clotting laboratory indices and thromboelastogram (TEG) parameters between pregnant women with gestational diabetes mellitus (GDM ) and healthy pregnant women .Methods The detection results of clotting laboratory indices and TEG in 46 pregnant women with GDM and 49 healthy pregnant women in our hospital from June 2013 to July 2014 were retrospectively analyzed and compared .Results In the comparison of the GDM group and the control group ,the traditional clotting laboratory indices ,INR and PT had statistically significant differences(P0 .05) .The common TEG indices of R value ,K value ,Angle ,MA value and CI value were statistically different between the GDM group and control group(P<0 .05) .Conclusion TEG is more sensitive than traditional clotting detection in monitoring the prethrombotic state of pregnant women with GDM and has certain significance for guiding early clinical intervention ,alleviating or delaying complications and improving the maternal and infantile outcome .
ABSTRACT
Objective To evaluate the alteration of coagulogram in patients with polycystic ovary syn -drome(PCOS).Methods Coagulogram was compared between 48 patients with PCOS and 42 healthy women. Pre-and post-therapy coagulogram were also compared and the correlation of coagulogram alternation and endocrine indicators were analyzed in PCOS patients .Results The mean age of the 48 PCOS patients was 27.6 ±4.2. Compared to the healthy women , PCOS patients presented higher body mass index , testosterone , insulin and fast-ing blood glucose levels ( P＜0.05 ) .Refer to the coagulogram , PCOS patients showed shorter prothrombin time and activated partial thromboplastin time , lower international normalized ratio of prothrombin time ratio , and the activity of thrombin(P＜0.05), longer thrombin time and lower fibrinogen , D Dimer and fibrin degradation prod-uct levels(P＜0.05).After three circles of treatment, the above indicators of coagulogram were recovered (P＜0.05).Moreover, the alteration of international normalized ratio was associated with fasting blood glucose and in-sulin significantly(P＜0.05).The alteration of D Dimer and fibrin degradation product were associated with fast-ing blood glucose, insulin and testosterone significantly (P＜0.05).Conclusions PCOS patients showed relative hypercoagulatory and hypofibrinolytic status which may be induced by hyperglycemia , hyperinsulinemia and hyper androgenemia.Thus, coagulogram should be monitored and interfered in PCOS patients to prevent thrombosis .
ABSTRACT
El coagulograma comprende un conjunto de pruebas que exploran la participación de todos los componentes de la hemostasia: endotelio vascular, actividad plaquetaria, factores plasmáticos y fibrinolíticos. Con frecuencia, la ejecución de estas pruebas resulta compleja para el personal técnico, por lo que la profundización en el conocimiento e interpretación de los resultados de cada una de estas, debe redundar en el fortalecimiento y preparación de los profesionales de la salud. En el presente trabajo se describen las principales pruebas del coagulograma convencional, el principio y los valores de referencia de cada una, así como las posibles enfermedades de acuerdo con la alteración del sistema hemostático que corresponde a la alteración del coagulograma, con el objetivo de brindarle al médico una información básica para la correcta ejecución y adecuada interpretación de los resultados
Coagulogram comprises a set of tests, which explore the participation of all components of hemostasia: vascular endothelium, platelet activity, plasma and fibrinolytic factors. Often, the technical staff finds complex to do these tests, so deepening knowledge, understanding, and interpreting the results of each of these tests should result in strengthening and training of health professionals. This paper describes the main conventional coagulation tests, the beginning and the reference values of each of them, and the possible diseases according to the alteration of the hemostatic system corresponding to the alteration of coagulation, with the aim of providing medical background information for the proper performance and proper interpretation of results