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Medicina (Guayaquil) ; 9(3): 203-209, 2003.
Article in Spanish | LILACS | ID: lil-652384

ABSTRACT

Diseño: Estudio cerrado realizado en el área de emergencia del hospital ¡§Dr. Teodoro Maldonado Carbo¡¨ del Instituto Ecuatoriano de Seguridad Social, con estigmas de dolor torácico o falla cardiaca, cuyo antecedente fue la hipertensión arterial, en quienes se analizó muestras sanguíneas para detectar homocisteina en ayunas, durante las primeras 24 horas de su ingreso.Objetivo: Evaluar prospectivamente, el riesgo de disección aórtica asociada a niveles plasmáticos elevados de homocisteina.Universo: 120 pacientes, raza mestiza, grupo etario comprendido entre los 28 y 71 años; edad promedio 65 años, predominio masculino, sin infarto de miocardio previo; 25 pacientes desarrollaron urgencias hipertensivas, edema agudo de pulmón; 61 pacientes síndrome coronario agudo, angina de clase III de Brauwald, y 34 pacientes se complicaron con disección aórtica.Medición del estudio: En quienes con hipertensión arterial, se relacionaban con hiperhomocistinemia y el desarrollo de disección aórtica.Propósito: Diagnóstico precoz de disección, algoritmo, protocolo específico ante esta patología con el uso de vasodilatadores, beta bloqueadores, cofactores enzimáticos, vitamina B6, ácido fólico, acetilcisteina, hasta su estabilización hemodinámica.


Design: Study of a population that went to the emergency room of the Dr. Teodoro Maldonado Carbo Hospital of the Ecuadorian Social Security Institute, with thoracic pain or heart failure who have a clinical history of hypertension in which we determined homocystein levels in the blood, during the first 24 hrs of the patients¡¦ arrival to the emergency room.Objective: A prospective study of the association of aortic dissection risk with the high blood levels of homocystein.Universe: 120 patients of racially mixed race, among the ages of 28-71 years being the average of 65 year of age being predominantly male, without a clinical history of myocardial infraction, 25 patients developed hypertensive emergencies and acute pulmonary edema, 61 patients developed acute coronary syndrome, class III Angina of the Brauwald, and 34 patients got complicated with aortic dissection.Measurement of the study: The relationship that exists in patients who have hypertension and development of hyperhomocysteinemia and aortic dissection. Purpose: „XTo be able to diagnose early an aortic dissection.„XTo have a specific protocol in the use of vasodilatators, beta blockers, enzymatic cofactors vitamin b6, folic Acid, acetilcystein until the patient is hemodinamically stable. Results: The homocystein levels were higher in patients with aortic dissection, 56% plasmatic level than 15umol/ml, the other patients that developed acute pulmonary edema were treated with the conventional therapy


Subject(s)
Male , Adult , Female , Middle Aged , Aortic Dissection , Aortic Aneurysm , Hyperhomocysteinemia , Acute Coronary Syndrome , Hypertension
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