ABSTRACT
In this study, we aimed to develop foods with antitumor and complementary effects against cisplatin (CDDP)-resistant bladder cancer. UMUC3, a human bladder cancer cell line was exposed to CDDP and cultured over a prolonged period to prepare UMUC3-CR, a CDDP-resistant subline. Androgen receptor mRNA expression was high in the UMUC3-CR subline. Genistein and vitamin C suppressed UMUC3-CR tumor growth. Additionally, the liberal intake of cheese in parental cell UMUC3-transplanted mice was associated with prolonged survival. Therefore, we created konjac jelly (KIK300) containing soy milk, cheese, and vitamin C as the main ingredients. Liberal administration of KIK300 to UMUC3-CR-transplanted mice suppressed tumor growth and reduced vascular endothelial growth factor mRNA expression. Furthermore, we observed no weight loss in the animals, their skin condition improved, and exercise capacity was improved. In conclusion, this study suggests that KIK300 may show antitumor and complementary effects on CDDP-resistant bladder cancer.
ABSTRACT
Kampo medicine and acupuncture have traditionally been compared to "two wheels of one cart". Both Kampo medicine and acupuncture have the main aim of eliciting the healing ability of human nature and treat the disease state grasped as "physical/mental distortion"to correct the distortion. Kampo medicine and acupuncture have a lot in common. For example, both respect the subjective symptoms, place an emphasis on removal of complaints and are based on individual care. By utilizing such common points and common direction of care, the combination therapy with Kampo medicine and acupuncture can contribute to alleviation of complaints and QOL (Quality of Life) improvement more effectively than each monotherapy alone. Furthermore, Kampo medicine and acupuncture increase the therapeutic effect of each other and a synergistic effect rather than the additive effect can be expected. <BR>On the other hand, Kampo medicine is basically taken by oral ingestion and treats the body from inside, whereas acupuncture is based on stimulation of acupuncture points of the body surface and treats the body from outside. Based on such difference, Kampo medicine and acupuncture have actually different favorite fields and different favorite disease states. It is therefore possible to realize a complementary therapy by utilizing the characteristics of each other.<BR>At the outpatient office of oriental medicine of Saitama Medical University, various combinations of Kampo medicine and acupuncture have been tried and it is often experienced that such combinations are useful to improve patient's QOL. Furthermore, in not a few patients, it is combination therapy that can show a high effect or combination therapy is essential. <BR>In this lecture, among the cases where combination therapies were effective, those for which the combination effect can be explained easily were presented and discussed. Some cases of chronic urticaria, fibromyalgia syndrome, low back pain (lumbar spondylosis), tension headache and patulous eustachian tube were raised. Kampo medicine added with acupuncture or acupuncture added with Kampo medicine could achieve further QOL improvement such as shortening of the duration of treatment until cure, improvement of complaints not resolved by each monotherapy and alleviation of accompanying symptoms.
ABSTRACT
Based on amino acid score of food, this article presents an "Amino Acid Score Difference (AASD) " for protein quality evaluation, the minus value of AASD representing the limiting amino acid and its number re- presenting the degree. The minus value in one food can be compensated by the positive value in another when we directly select the rational couple for amino acid complementation in diet. In addition, a calculation formula is introduced for amino acid complementation in two kinds of food or in mixed diet including many foods. It gives an effective means in evaluating the nutritional value of protein in foods and planning an ideal diet by selecting foods on the basis of amino acid complementation