Segmentation of retinal vessels by fusing contour information and conditional generative adversarial / 生物医学工程学杂志

The existing retinal vessels segmentation algorithms have various problems that the end of main vessels are easy to break, and the central macula and the optic disc boundary are likely to be mistakenly segmented. To solve the above problems, a novel retinal vessels segmentation algorithm is proposed in this paper. The algorithm merged together vessels contour information and conditional generative adversarial nets. Firstly, non-uniform light removal and principal component analysis were used to process the fundus images. Therefore, it enhanced the contrast between the blood vessels and the background, and obtained the single-scale gray images with rich feature information. Secondly, the dense blocks integrated with the deep separable convolution with offset and squeeze-and-exception (SE) block were applied to the encoder and decoder to alleviate the gradient disappearance or explosion. Simultaneously, the network focused on the feature information of the learning target. Thirdly, the contour loss function was added to improve the identification ability of the blood vessels information and contour information of the network. Finally, experiments were carried out on the DRIVE and STARE datasets respectively. The value of area under the receiver operating characteristic reached 0.982 5 and 0.987 4, respectively, and the accuracy reached 0.967 7 and 0.975 6, respectively. Experimental results show that the algorithm can accurately distinguish contours and blood vessels, and reduce blood vessel rupture. The algorithm has certain application value in the diagnosis of clinical ophthalmic diseases.

Cortical Folding On Medial Surface Of Foetal Brain At Different Gestational Age

Background: Cortical folding is a hallmark of many but not all mammalian brains. The degree of folding graduallyincreases with the size of brains in mammals but at different range between the families.Gyrification is a processwhich varies widely in mammals in early foetal and prenatal life.Materials: This study was conducted on 100 dead foetuses in anatomy department, brought from the departmentof Obstetrics and gynaecology of MNR Medical College and Hospital.Results: The brain surface is smooth up to 12 weeks,Cingulate sulcus appeared by 16-18weeks.Growth of adjoininglobes of brain make surface more convoluted with well-defined sulci and gyral pattern between 30-32 weeks.Conclusion: Cortical folding is due to consequence of restricted space and rapid growth of brain with in thecranial cavity. There is no differences between male and female brains of same gestational age, with no obviousasymmetrical development of gyri on different lobes of brain

A DenseNet-based diagnosis algorithm for automated diagnosis using clinical ECG data / 南方医科大学学报

OBJECTIVE@#To train convolutional networks using multi-lead ECG data and classify new data accurately to provide reliable information for clinical diagnosis.@*METHODS@#The data were pre-processed with a bandpass filter, and signal framing was adopted to adjust the data of different lengths to the same size to facilitate network training and prediction. The dataset was expanded by increasing the sample size to improve the detection rate of abnormal samples. A depth-wise separable convolution structure was used for more specific feature extraction for different channels of twelve-lead ECG data. We trained the two classifiers for each label using the improved DenseNet to classify different labels.@*RESULTS@#The propose model showed an accuracy of 80.13% for distinguishing between normal and abnormal ECG with a sensitivity of 80.38%, a specificity of 79.91% and a F1 score of 79.35%.@*CONCLUSIONS@#The model proposed herein can rapidly and effectively classify the ECG data. The running time of a single dataset on GPU is 33.59 ms, which allows real-time prediction to meet the clinical requirements.