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1.
Chinese Journal of School Health ; (12): 1542-1544, 2023.
Article in Chinese | WPRIM | ID: wpr-997224

ABSTRACT

Objective@#To explore the longitudinal relationship between upward social comparison and online aggressive behavior among college students, in order to provide an empirical evidence for educators to carry out mental health promotion for college students.@*Methods@#From December 2021 to March 2022, 539 college students from one university in Inner Mongolia were recruited to complete the Upward Social Comparison Questionnaire (USCQ) and Online Aggressive Behavior Scale (OABS) in a 4 month follow-up study. The structural equation model was used to conduct cross-lagged analysis.@*Results@#The mean scores of upward social comparison for college students tracked at baseline (T1) and 4 months follow-up (T2) were (2.77±0.93, 2.70±1.00) points, and the mean scores of online aggressive behavior were (1.06±0.13, 1.05±0.11) points. There were positive relations between upward social comparison and online aggressive behavior of college students at both cross-sectional levels ( r=0.14-0.19, P <0.05). In the autoregression, T1 upward social comparison could positively predict T2 upward social comparison ( β =0.66), and T1 online aggressive behavior could positively predict T2 online aggressive behavior ( β =0.47)( P <0.01); In the cross-lagged regression, T1 upward social comparison could positively predict T2 online aggressive behavior ( β=0.10, P <0.01), whereas T1 online aggressive behavior could not predict T2 upward social comparison ( β=0.04, P >0.05).@*Conclusion@#Upward social comparison is the cause of online aggressive behavior among college students. The probability of online aggressive behavior among college students should be reduced by guiding students to correctly view the gap between themselves and others.

2.
Shanghai Journal of Preventive Medicine ; (12): 33-36, 2022.
Article in Chinese | WPRIM | ID: wpr-920534

ABSTRACT

Objective To investigate the risk of fatal stroke mortality associated with short-term exposure to air pollution, and to determine the susceptible population. Methods In this study, daily stroke mortalities of adults between 2012 and 2014 in Songjiang District, Shanghai were collected. Time-stratified case-crossover approach was used to assess the association between daily concentrations of air pollutants and fatal stroke mortalities. Results This study included 514 patients who died from acute strokes. The average concentrations during the study period were 77.45 μg·m-3 for PM2.5, 21.22 μg·m-3 for SO2, and 57.59 μg·m-3 for NO2. The fatal stroke mortality of adults under the age of 65 was found to be significantly associated with NO2. At the time of a Lag of 2 d and 03 d, a significantly higher risk of fatal stroke mortality in relation to NO2 exposure was observed, and the OR values of ischemic stroke mortality for people were 3.86 (1.53-9.75) and 5.83 (1.40-24.34) respectively. People over the age of 65 were more sensitive to increased PM2.5 concentrations, at the time of a Lag of 03 d, fatal strokes increased by 28% when PM2.5 levels increased. A significantly higher risk of fatal stroke mortality in relation to increase of NO2 concentration was observed among people who were overweight or obese. Conclusion A significantly higher risk of fatal stroke mortality is associated with the increase of PM2.5 and NO2. The results also suggest that the susceptible population should take additional precautions to avoid or reduce the risk of fatal strokes.

3.
Chinese Journal of Clinical Pharmacology and Therapeutics ; (12): 395-400, 2021.
Article in Chinese | WPRIM | ID: wpr-1015047

ABSTRACT

AIM: To investigate the application of two-stage estimation (TSE) on adjustment for treatment switch in oncology trials. METHODS: The theory and implementation of TSE method was described, and was applied to adjust the data from a two-arm randomized controlled trial of anti-tumor drugs. The changes of survival curves and hazard ratio of two groups after adjustment for cross-over were evaluated. In addition, the results of two-stage estimation and rank preserving structural failure time model (RPSFT) were compared. RESULTS: After adjustment for cross-over using TSE methods, the results showed that the median survival time of control group was shorter than the original one, and the hazard ratio was lower than the observed value. Moreover, TSE method showed similar results to rank preserving structural failure time model. CONCLUSION: The TSE method is relatively simple to use, reliable and has a good practice property in cross-over analysis of oncology trials. At the same time, it is necessary to pay attention to its application scopes.

4.
Journal of Integrative Medicine ; (12): 203-210, 2021.
Article in English | WPRIM | ID: wpr-881015

ABSTRACT

N-of-1 trial designs have rarely been used in bodywork research. Using a recent trial as a methodological pilot, critical issues related to the applicability of N-of-1 trials to bodywork are discussed. These include the issues of carry-over effects, bias-controlling approaches and statistical analysis. The discussion highlights the importance of mixed methods and draws some suggestions for a future research program. N-of-1 trials could be used to provide insights about some essential elements of bodywork modalities and their effectiveness.

6.
Nutrition Research and Practice ; : 105-114, 2019.
Article in English | WPRIM | ID: wpr-741709

ABSTRACT

BACKGROUND/OBJECTIVES: Several previous studies have investigated whether regular walnut consumption positively changes heart-health-related parameters. The aim of this study was to investigate the effects of daily walnut intake on metabolic syndrome (MetS) status and other metabolic parameters among subjects with MetS. SUBJECTS/METHODS: This study was a two-arm, randomized, controlled crossover study with 16 weeks of each intervention (45 g of walnuts or iso-caloric white bread) with a 6 week washout period between interventions. Korean adults with MetS (n = 119) were randomly assigned to one of two sequences; 84 subjects completed the trial. At each clinic visit (at 0, 16, 22, and 38 weeks), MetS components, metabolic parameters including lipid profile, hemoglobin A1c (HbA1c), adiponectin, leptin, and apolipoprotein B, as well as anthropometric and bioimpedance data were obtained. RESULTS: Daily walnut consumption for 16 weeks improved MetS status, resulting in 28.6%-52.8% reversion rates for individual MetS components and 51.2% of participants with MetS at baseline reverted to a normal status after the walnut intervention. Significant improvements after walnut intake, compared to control intervention, in high-density lipoprotein cholesterol (HDL-C) (P = 0.028), fasting glucose (P = 0.013), HbA1c (P = 0.021), and adiponectin (P = 0.019) were observed after adjustment for gender, age, body mass index, and sequence using a linear mixed model. CONCLUSION: A dietary supplement of 45 g of walnuts for 16 weeks favorably changed MetS status by increasing the concentration of HDL-C and decreasing fasting glucose level. Furthermore, consuming walnuts on a daily basis changed HbA1c and circulating adiponectin levels among the subjects with MetS. This trial is registered at ClinicalTrials.gov as NCT03267901.


Subject(s)
Adult , Humans , Adiponectin , Ambulatory Care , Apolipoproteins , Body Mass Index , Cholesterol , Cross-Over Studies , Dietary Supplements , Fasting , Glucose , Juglans , Leptin , Lipoproteins
7.
Dement. neuropsychol ; 12(2): 189-195, Apr.-June 2018. tab
Article in English | LILACS | ID: biblio-952962

ABSTRACT

Abstract The surrounding circumstances and environments of Malaysian older adults could make conducting interventions (mainly in terms of clinical or randomized controlled trials) a challenge. Working with older adults and facing cultural issues could be challenging. Objective: This paper illustrates a significant perspective of some of the challenges faced while conducting a randomized controlled trial exploring the impact of a multi-component intervention that included strategy- and process-based prospective memory (PM) training among Malaysian older adults. Methods: The current study was a randomized controlled trial (RCT) and therefore the challenges were presented in accordance with the CONSORT statement style. Results: A discussion on how these issues were addressed is provided. Conclusion: Some suggestions were presented to help researchers plan and create interventions for similar studies and to support a practical method of addressing all related challenges.


Resumo As circunstâncias e ambientes circundantes de adultos idosos da Malásia poderiam tornar a condução da intervenção (principalmente em termos de ensaios clínicos ou randomizados controlados) um desafio. Trabalhar com adultos mais velhos e enfrentar problemas culturais pode ser instigante. Objetivo: Este artigo ilustra uma perspectiva significativa de alguns dos desafios enfrentados durante a realização de um estudo controlado randomizado que explora o impacto de uma intervenção de múltiplos componentes, incluindo treinamento de memória prospectiva baseado em estratégia e processo (PM) entre idosos da Malásia. Métodos: Como o estudo atual foi um ensaio clínico randomizado (ECR), os desafios foram apresentados de acordo com o estilo de declaração CONSORT. Resultados: Uma discussão sobre como essas questões foram abordadas é fornecida. Conclusão: Algumas sugestões foram apresentadas para ajudar os pesquisadores a planejar e criar intervenções para estudos semelhantes e capacitar um método prático para abordar todos os desafios relacionados.


Subject(s)
Humans , Cross-Over Studies , Aged , Memory, Episodic , Learning
8.
Journal of Audiology & Otology ; : 28-38, 2018.
Article in English | WPRIM | ID: wpr-740315

ABSTRACT

BACKGROUND AND OBJECTIVES: It is important to understand the frequency region of cues used, and not used, by cochlear implant (CI) recipients. Speech and environmental sound recognition by individuals with CI and normal-hearing (NH) was measured. Gradients were also computed to evaluate the pattern of change in identification performance with respect to the low-pass filtering or high-pass filtering cutoff frequencies. SUBJECTS AND METHODS: Frequency-limiting effects were implemented in the acoustic waveforms by passing the signals through low-pass filters (LPFs) or high-pass filters (HPFs) with seven different cutoff frequencies. Identification of Korean vowels and consonants produced by a male and female speaker and environmental sounds was measured. Crossover frequencies were determined for each identification test, where the LPF and HPF conditions show the identical identification scores. RESULTS: CI and NH subjects showed changes in identification performance in a similar manner as a function of cutoff frequency for the LPF and HPF conditions, suggesting that the degraded spectral information in the acoustic signals may similarly constraint the identification performance for both subject groups. However, CI subjects were generally less efficient than NH subjects in using the limited spectral information for speech and environmental sound identification due to the inefficient coding of acoustic cues through the CI sound processors. CONCLUSIONS: This finding will provide vital information in Korean for understanding how different the frequency information is in receiving speech and environmental sounds by CI processor from normal hearing.


Subject(s)
Female , Humans , Male , Acoustics , Clinical Coding , Cochlear Implants , Cues , Hearing
9.
Braz. oral res. (Online) ; 31: e32, 2017. tab, graf
Article in English | LILACS | ID: biblio-839525

ABSTRACT

Abstract In recent years, different chlorhexidine formulations have been tested, including an alcohol-free alternative, but the effect of this solution on early biofilm formation is not clear. A crossover, randomized, double-blind clinical trial was conducted to evaluate the effect of two chlorhexidine solutions against supra- and subgingival biofilm formation (NCT#02656251). Thirty-five participants were randomized and asked to rinse twice daily with 15 ml of an alcohol-containing 0.12% chlorhexidine solution, an alcohol-free 0.12% chlorhexidine solution, or placebo. The study was conducted in three experimental periods of 4 days each, with a 10-day washout between the periods. All the experimental periods followed the same protocol, except that the solutions were switched. Biofilm distribution was evaluated every 24 hours by the Plaque-Free Zone Index, during 96 hours. Adverse events were self-reported and sensory evaluation was performed using a hedonic scale. Compared to the placebo, the chlorhexidine solutions resulted in a significantly higher number of surfaces free of plaque over 96 hours (p < 0.01), and were able to prevent subgingival biofilm formation (p < 0.01). The alcohol-free chlorhexidine solution was associated with a lower incidence of adverse events, compared with alcohol-containing chlorhexidine (p < 0.05); it also received better sensory evaluation and acceptance by trial participants, compared with the alcohol-containing chlorhexidine (p = 0.007), and had a similar inhibitory effect on the formation of supra- and subgingival biofilms.


Subject(s)
Humans , Male , Female , Adolescent , Adult , Young Adult , Biofilms/drug effects , Chlorhexidine/chemistry , Chlorhexidine/pharmacology , Ethanol/chemistry , Ethanol/pharmacology , Mouthwashes/chemistry , Mouthwashes/pharmacology , Anti-Infective Agents, Local/chemistry , Anti-Infective Agents, Local/pharmacology , Cross-Over Studies , Dental Plaque Index , Dental Plaque/prevention & control , Double-Blind Method , Drug Combinations , Gingiva/drug effects , Gingiva/microbiology , Taste , Time Factors , Treatment Outcome
10.
Chinese Journal of Epidemiology ; (12): 1436-1440, 2017.
Article in Chinese | WPRIM | ID: wpr-737848

ABSTRACT

This paper introduces the revised Cochrane bias risk assessment tool for individual randomized,cross-over trials (RoB2.0),comparing RoB2.0 of cross-over design with RoB2.0 of parallel design,and illustrating the application of RoB2.0 for cross-over trials in a published clinical trial.As a comprehensive tool specially designed for cross-over design,it provides more information on risk of bias in systematic reviews for the evidence synthesis.

11.
Chinese Journal of Epidemiology ; (12): 1436-1440, 2017.
Article in Chinese | WPRIM | ID: wpr-736380

ABSTRACT

This paper introduces the revised Cochrane bias risk assessment tool for individual randomized,cross-over trials (RoB2.0),comparing RoB2.0 of cross-over design with RoB2.0 of parallel design,and illustrating the application of RoB2.0 for cross-over trials in a published clinical trial.As a comprehensive tool specially designed for cross-over design,it provides more information on risk of bias in systematic reviews for the evidence synthesis.

12.
Malaysian Journal of Nutrition ; : 343-352, 2017.
Article in English | WPRIM | ID: wpr-732031

ABSTRACT

Introduction: This is a preliminary result of an on-going randomised cross-over trial to compare the effects of consuming yellowstripe scad (YSS) and salmon, both rich in omega-3 fatty acids, on lipid profile, fasting glucose, body weight status, and blood pressure among healthy overweight adults. Methods: Fifty healthy overweight Malaysians aged 21-55 years were recruited voluntarily through advertisements. During the first period of intervention, subjects were randomised equally to receive eight weeks of either steamed whole YSS fish (YSS group) or salmon fillet (salmon group), three days per week, obtaining approximately 7000 mg EPA+DHA per week. The diets were switched after an eight-week washout period. Lipid profile, fasting glucose, body mass index, and blood pressure were evaluated before and after each intervention period. Results: The mean ages of YSS group (n=25) and salmon (n=25) group were 30.6?±9.1 and 27.9?±7.1 years respectively. Both groups had no statistically significant differences on socio-demographic characteristics (p>0.05). After the first intervention period, there was a significant increase in total cholesterol within the YSS group (p0.05). Both YSS and salmon groups had significantly higher HDL-cholesterol levels after 8 weeks compared to baseline (p0.05). However, there was a significant effect of time on diastolic blood pressure (p<0.05). Conclusion: These preliminary findings indicate that YSS and salmon may have similar beneficial effects on HDL-cholesterol level among healthy overweight adults. The second intervention period is on-going to confirm these finding

13.
International Journal of Cerebrovascular Diseases ; (12): 27-32, 2017.
Article in Chinese | WPRIM | ID: wpr-513297

ABSTRACT

Objective To investigate the correlation between 6 common triggers and ischemic stroke.Methods The demographic and clinical data of the consecutive inpatients with acute ischemic stroke were collected.A questionnaire survey of the triggers of the disease was conducted within 4 d after admission.A case cross-over study was used to compare the exposure of the 6 potential triggers (overeating,anger,negative emotion,heavy physical activity,sudden posture changes as response to a startling event,drinking coffee) at 2 h before onset (dangerous period) and at 1 d before onset during the same period (control period),and exposures to potential triggers in patients according to gender,age and etiological subtypes were further analyzed.Results A total of 369 patients were enrolled.They aged 24-93 years old (mean 61.75 ±13.57),220 patients were male (59.6%) and 149 were female (40.4%).A total of 91 patients (24.7%) exposed to at least one of the triggers at 2 h before onset (odds ratio [OR] 6.1,95% confidence interval [CI] 3.7-9.9);OR for exposure to the sudden posture change in response to a startling event was 12.0 (95% CI 2.4-59.3),for heavy physical activity 10.7 (95% CI 4.2-27.6),for anger 8.0 (95% CI 2.3-27.5),and for negative emotion 4.9 (95% CI 2.3-10.3).There was no exposure to drinking coffee.There were no significant differences in the exposure to various triggers among the different gender,age,and etiological subtypes.Conclusions Sudden posture changes as response to a startling event,heavy physical activity,anger,and negative emotion are the triggers for ischemic stroke,attention should be paid to the influence of triggers in the prevention of ischemic stroke.

14.
Arch. endocrinol. metab. (Online) ; 60(6): 562-572, Nov.-Dec. 2016. tab, graf
Article in English | LILACS | ID: biblio-827785

ABSTRACT

ABSTRACT Objective To compare the effects of a unique fixed combination levothyroxine/liothyronine (LT4/LT3) therapy in patients with primary hypothyroidism. Subjects and methods This is a randomized, double-blind, crossover study. Adults with primary hypothyroidism (n = 32, age 42.6 ± 13.3, 30 females) on stable doses of LT4 for ≥ 6 months (125 or 150 μg/day) were randomized to continue LT4 treatment (G1) or to start LT4/LT3 therapy (75/15 μg/day; G2). After 8 weeks, participants switched treatments for 8 more weeks. Thyroid function, lipid profile, plasma glucose, body weight, electrocardiogram, vital signs, and quality of life (QoL) were evaluated at weeks 0, 8 and 16. Results Free T4 levels were significantly lower while on LT4/LT3 (G1: 1.07 ± 0.29 vs. 1.65 ± 0.46; G2: 0.97 ± 0.26 vs. 1.63 ± 0.43 ng/dL; P < 0.001). TSH and T3 levels were not affected by type of therapy. More patients on LT4/LT3 had T3 levels above the upper limit (15% vs. 3%). The combination therapy led to an increase in heart rate, with no significant changes in electrocardiogram or arterial blood pressure. Lipid profile, body weight and QoL remained unchanged. Conclusions The combination therapy yielded significantly lower free T4 levels, with no changes in TSH or T3 levels. More patients on LT4/T3 had elevated T3 levels, with no significant alterations in the evaluated outcomes. No clear clinical benefit of the studied formulation could be observed. Future trials need to evaluate different formulations and the impact of the combined therapy in select populations with genetic polymorphisms.


Subject(s)
Humans , Male , Female , Adult , Middle Aged , Thyroxine/therapeutic use , Triiodothyronine/therapeutic use , Hypothyroidism/drug therapy , Quality of Life , Thyroid Function Tests , Thyroxine/blood , Thyroxine/pharmacology , Triiodothyronine/blood , Triiodothyronine/pharmacology , Blood Glucose/analysis , Body Weight/drug effects , Thyrotropin/drug effects , Cholesterol/blood , Double-Blind Method , Cross-Over Studies , Drug Combinations , Hypothyroidism/blood
15.
Nutrition Research and Practice ; : 590-596, 2016.
Article in English | WPRIM | ID: wpr-100890

ABSTRACT

BACKGROUND/OBJECTIVES: The purpose of this study was to examine whether plasma lipid profiles are affected differently by snack kinds with equal calorific values. SUBJECTS/METHODS: We compared a Korean traditional confectionery (dasik) with Western confectionery (cookie) in this regard. Controlled cross-over study consisted of two 3-week snack intake phases and for separating, a 2-week washout period (3–2–3) was carried out with 30 healthy women aged between 40-59 years old. Brown rice based Korean traditional confectionery and wheat flour based Western confectionery were used. The participants consumed either dasik or cookie every day for 3 weeks, providing 93 kcal a day. RESULTS: The total cholesterol (TC) in the dasik group had decreased significantly after 3 weeks (P < 0.05). Furthermore, in the dasik group, reduction in TC and low-density lipoprotein-cholesterol were greater than those in the cookie group (P < 0.05). CONCLUSIONS: Prioritizing functional snacks like dasik improves plasma lipid profiles; this may be useful information for individuals who cannot refrain from snacking.


Subject(s)
Female , Humans , Cholesterol , Cross-Over Studies , Flour , Plasma , Snacks , Triticum
16.
Hanyang Medical Reviews ; : 11-16, 2016.
Article in English | WPRIM | ID: wpr-169723

ABSTRACT

People with Asperger's syndrome (AS) have a rather different thinking style. They may create new ideas that the designer can see this awkward thinking style as the driver for developing new and innovative ideas. In this paper, both 'Aspie' and the designer work together to make innovative ideas, by which 'Aspie' could find a new contributive role in communal living. An ideation workshop is composed of two different stages with several ideation methods. Described is an observational study of how the ideation workshop covers their deficits and makes them adapt to generate their different ideas. From the observation, this paper realizes how we start to reestablish the relationship between AS people and the society.


Subject(s)
Asperger Syndrome , Cross-Over Studies , Education , Equipment Design , Observational Study , Thinking
17.
Journal of International Pharmaceutical Research ; (6): 394-397, 2015.
Article in Chinese | WPRIM | ID: wpr-467805

ABSTRACT

Objective To establish and optimize the rat jugular vein catheterization model in our lab, and perform a cross-over study using this model to compare the pharmacokinetic characters of a newly developed midazolam formulation to the existing preparation. Methods Six SD rats (half male and half female) received the right jugular vein catheterization when the rats were sufficiently anesthetized. One week after the operation, all the rats were used to conduct a cross-over double period pharmacokinetic study. Totally1.33 mg/kg midazolam solutions from automatic needle and clinic available injection were adminisered to the jugular vein catheterization rats via im route. The washout period was 5 days. Exact volume of blood samples at designed time points were taken through the catheter. After preparation, the concentrations of midazolam in rat plasma were determined by using established LC-MS/MS method. The corresponding pharmacokinetic parameters were calculated by WinNolin software. Results The rat jugular vein catheterization model was successfully built. Blood was easily sampled and rats were well tolerated, meeting the requirement of repeated blooding. This model solved the bottleneck of cross-over study performed in rats. The pharmacokinetic behavior of newly developed midazolam formulation had no difference with that of clinic injections. The relative bioavailability was around 99%. Conclusion Rat jugular vein catheterization model is proved to be that of a propagating technique to do the cross-over study and to evaluate the pharmacokinetic characters of novel formulations.

18.
Journal of International Pharmaceutical Research ; (6): 394-397, 2015.
Article in Chinese | WPRIM | ID: wpr-845702

ABSTRACT

Objective To establish and optimize the rat jugular vein catheterization model in our lab, and perform a crossover study using this model to compare the pharmacokinetic characters of a newly developed midazolam formulation to the existing preparation. Methods Six SD rats (half male and half female) received the right jugular vein catheterization when the rats were sufficiently anesthetized. One week after the operation, all the rats were used to conduct a cross-over double period pharmacokinetic study. Totally1.33 mg/kg midazolam solutions from automatic needle and clinic available injection were adminisered to the jugular vein catheterization rats via im route. The washout period was 5 days. Exact volume of blood samples at designed time points were taken through the catheter. After preparation, the concentrations of midazolam in rat plasma were determined by using established LC-MS/MS method. The corresponding pharmacokinetic parameters were calculated by WinNolin software. Results The rat jugular vein catheterization model was successfully built. Blood was easily sampled and rats were well tolerated, meeting the requirement of repeated blooding. This model solved the bottleneck of cross-over study performed in rats. The pharmacokinetic behavior of newly developed midazolam formulation had no difference with that of clinic injections. The relative bioavailability was around 99% . Conclusion   Rat jugular vein catheterization model is proved to be that of a propagating technique to do the cross-over study and to evaluate the pharmacokinetic characters of novel formulations.

19.
Braz. dent. j ; 25(5): 391-398, Sep-Oct/2014. tab, graf
Article in English | LILACS | ID: lil-731052

ABSTRACT

The aim of the present study was to assess the effect of a denture adhesive (DA) on patient satisfaction and kinesiographic parameters of complete denture wearers by a cross-over study. Fifty edentulous patients received a set of new complete dentures. After an adaptation period, the participants were enrolled in the trial and randomized to receive a sequence of treatment protocols: Protocol 1- DA use during the first 15 days, followed by no DA for the next 15 days; Protocol 2- no DA during the first 15 days, followed by use of DA for the next 15 days. Outcomes were assessed after 15 days of each sequence of treatment. A questionnaire was used to assess the patients´ satisfaction. A kinesiograph was used to record mandible movements and patterns of maxillary complete denture movement during chewing. The Wilcoxon test (α=0.05) and a paired sample t-test (α=0.05) were used to compare satisfaction levels and kinesiographic data, respectively. Use of DA improved the overall level of patient satisfaction (p<0.001). The kinesiographic recordings revealed a significant increase (1.7 mm) in vertical mandible movements (p<0.001) during chewing and a lower (0.3 mm) vertical intrusion of the maxillary complete dentures (p=0.002) during chewing after using the DA. Use of DA in complete denture wearers improved the patients´ satisfaction and altered mandible movements, with increases in vertical movements during chewing and less intrusion of maxillary complete dentures.


O objetivo deste estudo foi avaliar o efeito da utilização de um adesivo para prótese na satisfação e nos parâmetros cinesiográficos em usuários de próteses totais por meio de um estudo "cross-over". Cinquenta pacientes desdentados receberam novas próteses totais bimaxilares. Após um período de adaptação, os participantes incluídos no estudo receberam uma sequência de tratamento: Protocolo 1- utilização do adesivo para prótese durante os primeiros 15 dias, seguida por não utilização do adesivo os próximos 15 dias; Protocolo 2- não utilização do adesivo durante os primeiros 15 dias; seguida por utilização do adesivo nos próximos 15 dias. Os resultados foram avaliados após 15 dias de cada sequência de tratamento. Um questionário para avaliar a satisfação dos pacientes e um cinesiógrafo para registrar os movimentos mandibulares e o padrão de movimento da prótese total maxilar durante mastigação foram utilizados. O teste de "Wilcoxon" (α=0,05) e o "t-test" de Student para amostras pareadas (α=0,05) foram utilizados para comparar o grau de satisfação dos pacientes e os dados cinesiográficos, respectivamente. O adesivo para prótese melhorou significativamente a satisfação geral dos participantes (p<0,001). Os registros cinesiográficos mostraram um aumento significativo (1,7 mm) no movimento mandibular vertical (p<0,001) e uma menor intrusão (0,3 mm) da prótese total superior (p=0,002) durante a mastigação após o uso de adesivo. O uso de adesivo para prótese melhorou a satisfação dos usuários de próteses totais e gerou um aumento no movimento mandibular vertical e uma menor intrusão da prótese total maxilar durante a mastigação.


Subject(s)
Animals , Male , Rats , Gastrin-Secreting Cells/metabolism , Gastrins/metabolism , Somatostatin-Secreting Cells/metabolism , Somatostatin/metabolism , Stomach Ulcer/physiopathology , Disease Models, Animal , Gastric Mucosa/cytology , Gastric Mucosa/metabolism , Rats, Wistar , Stomach Ulcer/chemically induced
20.
Araraquara; s.n; 2013. 116 p. ilus.
Thesis in Portuguese | LILACS, BBO | ID: biblio-866882

ABSTRACT

O objetivo do presente estudo foi avaliar a influência da utilização de um adesivo para prótese (Ultra Corega creme) na formação de biofilme sobre a superfície interna de próteses totais e na microbiota bucal, no grau de satisfação, além da estimativa de custo médio diário do produto. Trinta pacientes receberam próteses totais novas, e foram divididos em dois protocolos: protocolo 1- utilização do adesivo durante os primeiros 15 dias de teste, seguida por não utilização de nenhum tipo de adesivo durante os próximos 15 dias; protocolo 2- não utilização de adesivo durante os primeiros 15 dias de teste, seguida por utilização do adesivo durante os próximos 15 dias. Após cada período de 15 dias, o biofilme formado na superfície interna das próteses totais foi corado e quantificado por meio de um método fotográfico com o auxílio de um software (Image Tool 3.00). Amostras de material da mucosa palatina e da superfície interna das próteses superiores foram plaqueadas em meios seletivos para Candida spp. e Streptococcus mutans e em um meio não seletivo. Ainda, foi aplicado um questionário para avaliação da satisfação com as próteses e o custo médio diário do produto foi estimado por meio de fórmulas matemáticas. Todas as análises foram realizadas com α = 0,05 e foram empregados testes apropriados à distribuição dos dados. Foi observada formação de biofilme semelhante com ou sem o uso do adesivo sobre as próteses superiores (Wilcoxon, p=0,255) e inferiores (Wilcoxon, p=0,433). Contagens de colônias semelhantes foram observadas com ou sem a utilização do adesivo na mucosa e na superfície interna da prótese total superior (p>0,05). O uso de adesivo proporcionou maior satisfação aos participantes (Wilcoxon, p=0,04). Em média, cada paciente utilizou 3,9 ± 0,3 gramas de adesivo por dia...


The aim of this study was to evaluate the influence of adhesive usage (Ultra Corega cream) on biofilm formation on the internal surface of dentures and oral microbiota, degree of satisfaction, and the estimated average daily cost of product. Thirty patients received new dentures, and have been divided into two protocols: Protocol 1-use of the adhesive during the first 15 days of the test, followed by not using adhesive over the next 15 days; Protocol 2- no use of adhesive for the first 15 days of the test, followed by use of adhesive over the next 15 days. After each period of 15 days, the internal surfaces of the dentures were stained and photographed and the areas (total internal surface and surface stained with biofilm) quantified (Image Tool 3.00). Samples of material from the palatal mucosa and the internal surface of the maxillary denture were plated on selective media for Candida spp. and Streptococcus mutans and a non-selective medium. A questionnaire was applied to evaluate satisfaction with the dentures and the average daily cost of the product was estimated by mathematical formulas. All analyzes were performed with α=.05 and appropriate tests were applied to the data distribution. Similar biofilm formation was found with or without adhesive usage for maxillary (Wilcoxon, p=.255) and mandibular dentures (Wilcoxon, p=.433). Similar colony counts were observed with or without adhesive for mucosa and the internal surface of dentures, irrespective of the culture medium (p>.05). The use of adhesive provided higher satisfaction (Wilcoxon, p=.04). On average, each patient used 3.9 ± 0.3 grams of adhesive per day, equivalent to R $ 4.02 for average daily cost. It is concluded that the use of the adhesive did not affect the quantification of the biofilm and the oral microbiota, besides providing greater overall satisfaction


Subject(s)
Humans , Adhesives , Biofilms , Cross-Over Studies , Denture, Complete
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