ABSTRACT
The coexistence of chronic myeloid leukaemia(CML) and chronic lymphocytic leukemia(CLL) has been reported occasionally in literature, with only seven cases of simultaneous occurrence of these two diseases. We present here a case of 57 yr male patient where a complete blood count and differential done using volume conductivity scatter (VCS) technology suggested a diagnosis of CML with CLL. It was further confi rmed by immunophneotyping and cytogenetic analysis. The patient was started on tyrosine kinase inhibitor, 400 mg once daily. Four months after the treatment, patient is doing fi ne with a count of 22 × 109/L and 64% lymphocytes.
ABSTRACT
NK/T cell lymphoma (NKTCL) is an aggressive malignant disease among Chinese.NKTCL is resistant to conventional chemotherapy regimen with poor long-term survival rate.With new progress about the mechanism of this disease,some novel chemotherapy regimens have been developed and greatly improved the outcome.This review focused on the recent understanding in the field of NKTCL oncogenesis,which may shed light on development of potential therapeutic targets of NKTCL.