The 50 most cited articles in the brazilian medical literature on knee surgery / Os 50 artigos mais citados da literatura médica brasileira sobre cirurgia do joelho

ABSTRACT Objective: To provide an analysis of the 50 most cited articles on knee surgery in the Brazilian medical literature. Methods: This is a study of systematic review and meta-analysis, level of evidence 3. It was carried out through search in the SCOPUS database to identify scientific articles published in the Brazilian medical literature. Eighty-six Brazilian journals were analyzed, and articles with ten or more citations and which had the word "joelho" or "knee" in the title, abstract or keywords were selected. Results: All articles were published as of the year 2000 in 14 journals. The Journal Clinics presented the largest number of publications, followed by Acta Ortopédica Brasileira. The main focus of the studies was on anatomy and biomechanics, mainly from Brazilian authors. Most of the authors were Brazilian, from Brazilian and public research institutions. Conclusion: Biometric analysis has been gaining ground in recent years, but its interpretation must consider various aspects related to the paramount analytical importance.

RESUMO Objetivo: Fornecer uma análise dos cinquenta artigos mais citados sobre cirurgia do joelho na literatura médica brasileira. Métodos: Foi utilizada a base de dados da SCOPUS para identificar artigos científicos publicados na literatura médica brasileira de 1945 a junho de 2008 com o tema referente ao joelho. Foram analisados 86 periódicos brasileiros e selecionados os artigos com número de citações igual ou superior a dez que possuíam a palavra "joelho" ou knee no título, resumo ou palavras-chave. Foram selecionados aqueles que possuíam a articulação do joelho como foco principal do estudo, chegando ao resultado final de cinquenta artigos mais citados. Resultados: Todos os artigos foram publicados a partir do ano 2000, em quatorze revistas. A Revista Clinics apresentou maior número de publicações, seguida da Acta Ortopédica Brasileira. A maior parte foi sobre estudos sobre anatomia e biomecânica, preponderamente de autores brasileiros. Instituições de pesquisa brasileiras e públicas foram as responsáveis pela maior parte das pesquisas. Conclusão: Análise biométrica vem ganhando espaço nos últimos anos, contudo sua interpretação deve considerar variados aspectos relacionados a importância analítica.

3D measurement assisted personalized full nose reconstruction / 实用医学杂志

Objective A database of normal people's external nose was established through 3D measurement. This database was used to customize the external nose for patients with nasal defects and to assist the operator to carry out the whole nose reconstruction surgery, so as to carry out the postoperative evaluation.Methods 3D scanning of the subject's face, measurement of relevant indexes of the nose and establishment of a database, the operator used normal nose database to customize the customized external nose for 17 patients with nasal defects, assisted them in the whole nose reconstruction surgery, and used independent sample t test for data statistics to evaluate the expected effect of surgery. Results There was no statistically significant differences between the postoperative actual data and the preoperative personalized data (P> 0.05) in right root wing distance, left root wing distance, nose length, nasal base width, nose width, right side vertical bisect nasal line, left side vertical bisect nasal line, nose height, medial malleolus spacing, face width, mouth split width, facial height, nasal width index, nasal width index, interondylar-nasal width index and nasal high index. The actual data of nasal deep was statistically different from preoperative personalized data (P < 0.05). Conclusions Analysis showed no significant difference between the actual data nasal surgery and preoperative customization data. 3D measurement of normal human external nasal establishment database to customize the external nose for patients with nasal defects, can assist the surgeon to perform total nasal reconstruction surgery and improve predictability and make surgery more precise. Postoperative assessments can also be performed to compare preoperative and postoperative outcomes.

Caracterização do gênero, da raça e da idade de uma população de 7. 780 cães da Região Central do Rio Grande do Sul submetidos à necropsia ao longo de cinco décadas (1964-2013) / Characterization of gender, breed and age in a population of 7. 780 dogs submitted for necropsy over five decades (1964-2013) in central Rio Grande do Sul, Brazil

Devido à ausência de um banco de dados demográficos da população canina que habita a Região Central do Rio Grande do Sul (RS) e à necessidade em se estabelecer uma "população controle" para a melhor interpretação da prevalência das doenças diagnosticadas pelo Laboratório de Patologia Veterinária (LPV-UFSM) da Universidade Federal de Santa Maria (UFSM), este estudo objetivou realizar uma análise das características relacionadas à raça, ao gênero e à idade dos cães necropsiados neste serviço de diagnóstico ao longo de 50 anos (1964-2013). Para isto, os laudos de necropsias de cães, realizadas entre 1964 e 2013, foram revisados, e deles foram retiradas informações referentes ao gênero, à idade e às raças de todos os cães oriundos dos municípios que compõem a Região Central do RS. Ao todo, 7.780 cães foram necropsiados; desses, 469 (6%) na primeira década (1964-1973), 1.133 (14,6%) na segunda década (1974-1983), 1.334 (17,1%) na terceira década (1984-1993), 1.705 (22%) na quarta década (1994-2003) e 3.139 (40,3%) na quinta década (2004-2013). Do total de cães com gênero informado nos laudos, 52,6% eram machos e 47,4% eram fêmeas. A mediana da idade de morte foi de três anos. Dos cães cuja raça foi informada nos laudos, 59,8% eram de raça definida (RD) e 40,2% não tinham raça definida (SRD). As raças de porte grande ou gigante mais frequentes foram: Pastor Alemão (17,2%), Boxer (6,9%), Rottweiler (5,3%), Fila Brasileiro (4,6%), Pointer Inglês (3,9%), Collie Pelo Longo (3,7%) Dobermann (3,7%) e Labrador Retriever (2,1%). As raças de porte pequeno ou médio mais frequentes foram: Poodle (8,9%), Dachshund (6,3%), Pinscher Miniatura (5,6%), Cocker Spaniel Inglês (4,5%), Pequinês (3,4%), Yorkshire Terrier (3,3%) e Terrier Brasileiro (2,8%). Houve um aumento na proporção de fêmeas e um crescimento na mediana referente à idade de morte ao longo das cinco décadas avaliadas. Apesar de não ter havido um aumento relevante na proporção de cães de RD em comparação com os SRD, observaram-se algumas mudanças na ocorrência de diferentes raças ao longo do tempo, incluindo principalmente uma dramática diminuição na percentagem de Pequinês, Terrier Brasileiro, Pointer Inglês e Pastor Alemão, e um aumento marcado na percentagem de Poodle, Dachshund, Rottweiler e Labrador Retriever. Os resultados aqui apresentados servirão como um subsídio comparativo para futuros estudos retrospectivos sobre prevalência de doenças em cães da Região Central do RS, auxiliando para uma mais correta compreensão e interpretação dos resultados encontrados nesses levantamentos de dados.(AU)

Based on the lack of demographic database on the canine population living in the midland region of Rio Grande do Sul State, Brazil, and on the need for a "control population" in the accomplishment of several prevalence-based studies of different diseases diagnosed at the Laboratório de Patologia Veterinária (LPV) of the Universidade Federal de Santa Maria (UFSM), the objective of this study was to describe the breed, gender and age characteristics of the population of dogs necropsied in this diagnostic service over 50 years (1964-2013). The protocols of necropsies performed on dogs and recorded in the LPV-UFSM between 1964 and 2013 were reviewed, and information related to gender, age and breed from dogs from all the districts within the Central Region of RS were separated. A total of 7,780 dogs were necropsied, among which 469 (6%) were registered in the first decade (1964-1973), 1,133 (14.6%) in the second decade (1974-1983), 1,334 (17.1%) in the third decade (1984-1993), 1,705 (22%) in the fourth decade (1994-2003) and 3,139 (40.3%) in the fifth decade (2004-2013). Of dogs whose gender was reported in the protocols, 52.6% were males and 47.4% were females. The median age of death was 3 years. Of dogs whose breed was reported in the protocols, 59.8% were purebred and 40.2% were mixed breed. The most common large and giant breed dogs were German Shepherd Dog (17.2%), Boxer (6.9%), Rottweiler (5.3%), Fila Brasileiro (4.6%), English Pointer (3.9%), Collie Rough (3.7%), Dobermann (3.7%), and Labrador Retriever (2.1%). The most common small and medium breed dogs were Poodle (8.9%), Dachshund (6.3%), Miniature Pinscher (5.6%), English Cocker Spaniel (4.5%), Pekingese (3.4%), Yorkshire Terrier (3.3%), and Brazilian Terrier (2.8%). The percentage of females and the median age of death showed an increase during the five decades of this study. Although there has been a significant increase in the proportion of pure breed dogs compared to mongrels, we observed some changes in the occurrence of different breeds over time, including a significant decrease in the frequency of the Pekingese, Brazilian Terrier, English Pointer, and German Shepherd Dog, and significant increase in the frequency of the Poodle, Dachshund, and Labrador Retriever. The results presented here will serve as an allowance for future comparative studies of disease prevalence in dogs of Central Region of RS, helping to a more correct understanding and interpretation of results from these data surveys.(AU)

Rapid identification of Brucella by MALDI-TOF MS / 国际检验医学杂志

Objective To establish Brucella peptide mass fingerprint database by MicroflexTMLT MALDI-TOF mass spectrometer ,and evaluate its application value in the identification of clinical isolates of Brucella. Methods In October 2013 ,a suspected Brucella strain was isolated in the microbiology laboratory of the hos-pital.It was confirmed as Brucella meltensis by VITEK ? 2 Compact automatic microbial analysis system and 16S rDNA gene sequencing.Brucella peptide mass fingerprint database was established with this strain ac-cording to the manufacturer's recommended method.Two suspected Brucella strains isolated in the laboratory in April 2015 and June 2016 were tested for Gram stain ,Kozlowski stain and biochemical reactions such as oxi-dase ,catalase and rapid urease activity.MicroflexTM LT mass spectrometer was used to collect the mass spec-trums of these two strains and three suspected Brucella strains isolated from other hospitals.When these spectrums were comparatively analyzed ,self-built database was added on the basis of the MALDI Biotyper da-tabase.The 16S rDNA gene sequencing was also used to identify the above-mentioned bacteria.Results Ac-cording to the recommended self-built database construction process ,Brucella peptide mass fingerprint data-base based on BRUxh1 was obtained successfully.The suspected Brucella strains isolated in April 2015 and June 2016 showed small Gram-negative coccobacillus under microscopic examination of stained smear ,and were positive for oxidase ,catalase ,urease activity (within 5 min).The identification results of mass spectrom- etry for the 5 suspected strains were all Brucella (mass spectrometry score :2.407 ,2.475 ,2.436 ,2.466 and 2.397).The 5 strains were confirmed as Brucella by 16S rDNA gene sequencing.Two strains among bacteria from other hospitals were falsely identified as Roseomonas gilardii by the VITEK?2 Compact system.Conclu-sion The combination of MALDI Biotyper database and self-built Brucella database can be used to compara-tively analyze the mass spectrometry of clinical isolates.Accurate identification of Brucella can be achieved by this means.The method which is fast and sensitive has high application value for rapid clinical diagnosis of Brucellosis.

Consolidación de un conjunto mínimo de datos para una historia clínica electrónica en atención primaria integral en salud enfocada en determinantes de la salud / Minimum - required - data set consolidation for an electronic medical record focused on primary care and health determinants / Consolidação de um conjunto mínimo de dados para una histórica clínica electrónica en atenção primária integral em saúde, focada nos determinantes sociais

Introducción Actualmente con la Política de Atención Integral en Salud y el Modelo Integral de Atención en Salud (MIAS) que busca una visión integral del riesgo y enfoque diferencial con base en las Rutas Integrales de Atención en Salud (RIAS) es necesario contar con una HCE que permita la integralidad y la calidad en la prestación de los servicios, optimización de los recursos y resultados clínicos eficaces y costo efectivos para el sistema de salud Colombiano.Objetivo. Consolidar el conjunto mínimo de datos de una historia clínica electrónica en APIS enfocada en determinantes de la saludMetodología. Estudio de alcance exploratorio, de carácter cualitativo do-cumental. Se tomaron como documentos base de revisión los trabajos de tesis académica, las directrices de las Rutas Integrales de Atención en Sa-lud (RIAS), los Catálogos del Ministerio de Salud y Protección Social y la propuesta del grupo de asesores de la línea de investigación de salud fa-miliar y atención primaria. Se elaboró un análisis documental que parte de la definición de categorías según los componentes de una historia clínica y se llevó a cabo una validación con la triangulación de la información y asesoría de expertos.Resultados. Se desarrolla el contenido de la historia clínica, los cuales contienen datos relevantes enfocados en atención primaria y determinan-tes de la salud, que conforman el conjunto mínimo de datos como base para la creación de una HCE en aras de consolidar un sistema de informa-ción interoperable, eficiente, y usable para profesionales de la salud.Conclusiones. Esta revisión genera conocimiento valioso para la imple-mentación de modelos integrales de HCE en atención primaria y provee temas a discutir para próximas investigaciones.

Overview. The enactment of Colombian Comprehensive Health Policy and the Comprehensive Health Care Model seek a tho-rough understanding of risk. It is therefore necessary to imple-ment an electronic medical record that allows for quality in health services provision, resource optimization and outcome efficacy within the Colombian healthcare system.Objective. Consolidating minimum required data set for an electronic medical record focused on primary care and health determinants.Methodology. An exploratory qualitative study was conducted and documents such as academic dissertations and handbooks produced by the Colombian Ministry of Health regarding pro-ceedings pertaining to primary health and family health re-search were reviewed. A documentary analysis on the com-ponents of an electronic medical record was implemented. Further validation was conducted through data triangulation and expert advice.Results. The content of the electronic medical record is develo-ped. Such relevant data are focused on primary care and health determinants which are the minimum required as a baseline to co-me up with an electronic medical record that consolidates an effi-cient, interoperable and user-friendly health information system.Conclusions. This documentary review reveals valuable knowled-ge for the implementation of integrated models of electronic me-dical record in primary care.

Introdução. Atualmente com a política de atenção integral em saúde e o modelo integral de atenção en saúde, MIAS, à procu-ra de uma abordagem que some a visão integral do risco com o enfoque diferencial, baseado nas rotas integrais de atenção, precisa de uma HCE que garanta bons serviços, otimização de recursos e resultados clínicos eficazes e costo-efetivos para o sistema de saúde nacional.Objetivo. Consolidar o conjunto mínimo de dados de una histó-ria clínica eletrônica em APIS focada nos determinantes sociais da saúde.Metodologia. O estudo é de caráter explotarório, qualitativo e documental. Foram considerados trabalhando de teses acadê-micas, diretrizes das Rotas Integrais, catálogos dos Ministério de Saúde e Proteção Social e propostas do grupo de pesquisa em saúde familiar e atenção primária. Realizou-se análisis do-cumental e definição de categorías segundo os conteúdos de uma história clínica, validada com ajuda de especialistas.Resultados. Foram desenvolvidos la conteúdos das históricas clínicas com aspectos próprios dos deteminantes sociais e atençæo primária, cómo base para a criação de uma HCE que busque consolidar un sistema de informação interoperável.Conclusões. Esta revisão aporta elementos Chávez para a im-plenentação de modelos Integrais de saúde.

A Preliminary Survey to Measure the Quality Indicators of End-of-life Cancer Care Using the Japanese National Database

Purpose: This survey aimed to develop a methodology for measuring the quality indicators of end-of-life care for cancer patients using the Japanese National Database, which was comprised of the health insurance claim data of all Japanese people. Methods: Life-sustaining treatment (LST) and chemotherapy near the time of death are accepted as reliable indicators of poor quality end-of-life care. To measure these, the Sampling Data Set (SDS) from the National Database (NDB) was used. Results: 1,233 cancer patients were studied, who had died from 14th to 31st October, 2012. The rates of LST and chemotherapy in the final 14 days of life were 8.2% (95%CI 6.7-10.1), 3.5% (2.6-4.8) for inpatients (n=1,079) respectively. In the SDS, 27-70% of chemotherapy drugs were not named, in order to prevent identification of patients receiving rare treatment. Discussion: The figures for rates of chemotherapy might be underestimated in the sampling data set, because of the anonymization of rare treatment. And in-patient and out-patient data may in some cases have been duplicated when entries applied to the same person. In the future using the NDB, it might be possible overcome some of these limitations.

DendroIDH: agrupando cidades por semelhança de indicadores / DendroHDI: clustering cities by similarity indicators / DendroIDH: intercalación de ciudades por indicadores de similitud

OBJETIVO: as cidades inteligentes estão surgindo mediante a necessidade de otimização de recursos e ampliação do bem-estar dos seus habitantes. Atualmente não existem dados claros sobre como comparar cidades inteligentes com base em indicadores que utilizem dados públicos, principalmente na área de Saúde. MÉTODO: este trabalho propõe a utilização de indicadores de IDH para comparar estatisticamente e agrupar cidades com semelhança de indicadores, e assim, oferecer aos seus gestores, a possibilidade de adotar estratégias de gestão baseadas em visualização de dados dispostos em dendrogramas. RESULTADO: foram realizados cálculos com a utilização de uma ferramenta estatística embases de dados públicas para obter dendrogramas de dados. CONCLUSÃO: o agrupamento de cidades por semelhança de indicadores se mostrou promissor para comparar e medir cidades com semelhantes características.

OBJECTIVE: Smart cities are emerging by the need to optimize resources and expansion of the welfare of its inhabitants. Currently there are no clear data on how to compare smart cities based on indicators using public data, especially in the health area. METHOD: this paper proposes the use of HDI indicators to compare statistically and grouptowns with similar indicators, and thus, offer its managers, the possibility of adopting management strategies based on data visualization arranged in dendrograms. RESULT: Calculations were performed using a statistical tool in public databases for dendrograms data. CONCLUSION: the grouping of cities by similarity indicators showed promise to compareand measure cities with similar characteristics.

Publindex: más que un proceso de indexación / Publindex: more than a simple indexing process

Este artículo, producto de investigación, expone las principales características del Sistema Nacional de Referencia para la Evaluación de Publicaciones Científicas colombianas (Publindex), logros, avances, interacciones y sus contribuciones a la medición de la publicación científica en el país.

This article, derived from a piece of research, sets out the main features of the National System of Reference for the Evaluation of the Colombian Scientific Publications (Publindex), achievements, progress, interactions, and their contributions to the measurement of scientific publications in the country.

Development of medical video resources in hospital libraries / 中华医学图书情报杂志

After an analysis of the application of medical video resources in academic conference , training of medical skills and health education of patients , the experiences in development of medical video resources in our li-brary were described.The characteristic medical video resources database was developed by establishing a naviga-tion system for free medical video resources on networks, introducing the mature academic video resources databases and collecting the medical video resources in our hospital .Service for medical video resources was popularized in forms of video reading and catalogue pushing .

<b>5．Practical Use of Medical Database for Risk Management Plan (RMP)</b> / 薬剤疫学

The notification of RMP was released in 2012 and has been adapted for new drug submission since 2013. However, most cases are usual post-marketing surveillance studies. According to the ICH E2E guideline, various risk managements could be possible, especially using medical database. Recently, large database has been developed. There are two kinds of database, hospital information system including electronic medical records, and claim data. Activities of using medical database in Japan, US, and Europe are various. Based on FDA amendment acts, FDA launched Sentinel Initiative in 2008 and REMS works effectively. The Mini-Sentinel and OMOP published Common Data Model respectively. FDA also released guidance for pharmacoepidemiologic studies using electronic health data. In Europe, RMP has been implemented in 2005 and about 36% are epidemiologic studies. ENCePP which was established in 2006 provides register of pharmacoepidemiologic and pharmacovigilance studies, checklist for protocols and guide on methodological standards in pharmacoepidemiology. In Japan, PMDA provides guideline for pharmacoepidemiologic studies using medical database. Also, “MID-NET” which is the standardized medical database has been developed. As a notable activity, PMDA has conducted pilots as MIHARI project and itʼs quite promising.

Insuficiencia cardíaca: análisis retrospectivo de una base de datos / Heart failure: retrospective study of a database

Introducción: La insuficiencia cardíaca es la enfermedad con mayor incidencia y la que produce más internaciones y gastos. Objetivos: Observar y describir información de una base de datos. Pacientes y métodos: Desde el 10 de junio de 1996 hasta el 25 de septiembre de 2011 se incluyeron 207 pacientes con seguimiento telefónico, en los cuales se evaluó principalmente etiología, evolución clínica y ecocardiográfica y fármacos utilizados. Resultados: La media de edad fue de 56 ± 11 años, la mediana de 57 años, el 82% era de sexo masculino y el 18%, femenino. Las etiologías más frecuentes fueron la isquémica y la hipertensiva no asociadas: 21.25% y 20.7%, respectivamente. De los 207 pacientes está actualmente en seguimiento el 35%, el 45% lo abandonó. El 6% fue derivado a trasplante cardíaco. La media desde el primer síntoma a la primera consulta fue de 35 ± 59 meses. El síntoma de inicio más frecuente fue disnea (53%). La clase funcional promedio al comienzo del seguimiento fue de 2.6 ± 0.85 y a la última consulta, de 2.21 ± 0.75 (p = 0.0001). Se constataron 28 defunciones (13%). Las causas de muerte más frecuentes fueron: muerte súbita 10 (37%) e insuficiencia cardíaca 7 (26%). La media de seguimiento fue de meses 19 ± 30. El 83% fue tratado con beta bloqueantes, el 81% con inhibidores de la enzima convertidora de angiotensina y el 64% con antialdosterónicos. Conclusiones: Con la implementación del seguimiento telefónico se cumplieron aceptablemente los objetivos propuestos y se mejoraron los resultados respecto del primero.

Introduction: Heart failure is the disease with the highest incidence of hospitalizations and expenditu-res. Objectives: To observe and describe information from a database. Materials and methods: From 10/06/1996 to 25/09/2011, 207 patients were followed up by telephone, primarily to assess disease etiology, clinical course, echocardiographic results and the use of drugs. Results: Mean age was 56 ± 11 years, median age 57, 82% were male and 18% female. The most frequent etiologies were non-associated ischemia and hypertension: 21.25% and 20.7% respectively. Of the 207 patients, 35% are currently under follow-up, while 45% abandoned. 6% were referred for heart transplantation. Time since the first symptom to the first consultation was 35 ± 59 months. The most common initial symp-tom was shortness of breath (53%). At the beginning of the follow-up, NYHA functional class was 2.6 ± 0.085, and 2.21 ± 0.75 (p = 0.0001) on the last visit. 28 deaths (13%) were documented. The most common causes of death were: sudden death, 10 (37%) and heart failure, 7 (26%). The mean follow-up time was 19 ± 30 months. 83% were treated with beta-blockers, 81% with ACE inhibitors and 64% with aldosterone antagonists. Conclusions: With the implementation of the telephone follow-up sys-tem, the proposed objectives were acceptably met, and compared with the first analysis, the reliability of results was improved.

Sistema web de base de datos para el asesoramiento de las comisiones provinciales de tuberculosis / Web data base system for the advisement of the provincial commissions of tuberculosis

Si bien la incidencia de la tuberculosis ha venido teniendo un comportamiento favorable en los últimos años en nuestro país, el trabajo de las Comisiones Provinciales de Tuberculosis se incrementa, al ser cada vez más disímiles y complejos los casos a valorar, los criterios diagnósticos y las conductas a tomar con los pacientes que se atienden. Para facilitar el trabajo de las comisiones se elaboró un sistema de base de datos para la web, destinado al asesoramiento diagnóstico y las conductas a seguir. El sistema pone a disposición de los especialistas y expertos de todas las comisiones del país la información de los casos atendidos que de ellas se derivan, de una manera sencilla, inmediata, fiable y coherente, permitiendo la generación automática de los formularios que recogen la información sobre los pacientes atendidos y las consultas que al sistema se realizan por los expertos. El uso del sistema permitirá reducir el tiempo para arribar a un diagnóstico certero, lo que económicamente reducirá los costos por complementarios realizados a los pacientes y la pronta reinserción de los mismos a la vida laboral y social. A la vez constituirá un medio de apoyo a la enseñanza, al facilitar la retroalimentación de los especialistas a partir del conocimiento vertido en el sistema por los expertos(AU)

Even though incidence of tuberculosis has had a favourable trend during the last years in our country, there has been an increase in the work at the provincial tuberculosis committees because cases assessed, diagnosis criteria and actions to be taken with patients are more and more diverse and complex. To facilitate the committees' work, a web-based management system was created; this is specifically a database to assess diagnosis and actions to be taken. This system makes accessible for all specialists and experts from all committees nationwide, the information of cases they have examined, in a simple, immediate, reliable and consistent way, making possible the automatic generation of forms to record the information on examined patients and of queries conducted by experts. This system will make possible to reduce the time needed to get an accurate diagnosis and from the financial point of view to cut costs from complementary tests for patients and through the prompt reinsertion of patients to their working and social lives. The system will also be a teaching resource since it will allow specialists to get a feedback from the information entered in the system by experts(AU)

Herramienta web para la clasificación de microsatélites polimórficos en genomas bacterianos / Web Tool for classfication of polymorphic microsatellites in bacteria genomes

Las secuencias repetidas en tándem, específicamente los mini y micro satélites, han demostrado ser muy eficaces en la clasificación de bacterias patogénicas como B. anthracis, M. tuberculosis y P. aeruginosa, entre otras. En humanos es manifiesta su participación estando relacionados con más de ochenta enfermedades, gran parte de ellas de tipo neurodegenerativas, musculares y algunos tipos de cáncer. La herramienta web que presentamos es el resultado de la detección computacional de estas secuencias en genomas bacterianos completos y su correspondiente anotación en la estructura genómica de acuerdo a las diferentes regiones donde estos se localizan. La herramienta tiene como fin primario brindar un sistema relacional que permita al investigador ubicar los microsatélites de diferentes especies bacterianas, con más de un genoma secuenciado para inferir su posible carácter polimórfico, dentro del contexto de la estructura genómica y así proveer un primer acercamiento al rol putativo que los microsatélites desempeñan desde el punto de vista funcional. La herramienta se puede aplicar no solo en estudios taxonómicos y epidemiológicos sino en la detección de posibles relaciones de estas secuencias con las funciones moleculares, procesos biológicos y, en última instancia, las diversas formas de evolución de estas especies. El sitio web brinda el servicio de consultas a la base de datos de microsatélites bacterianos de acuerdo al sistema de tablas relacionales y atributos propios de las mismas. Cuenta además con los servicios típicos de un sitio con estas características como: sistema de autenticación, foro, encuestas, enlaces y documentación sobre la metodología empleada y del tema en cuestión(AU)

The tandem repeat sequences, especially mini and microsatellites, have proven to be very effective in classification of pathogenic bacteria such as B. anthracis, M. tuberculosis and P. aeruginosa, among others. In human beings it is manifest its participation, being related with over eighty diseases, nearly all neurodegenerative and muscular, and some kinds of cancer. The web tool we are offering here is the result of computational detection of these sequences in whole bacteria genomes, and its respective annotation in the genomic structure according to the different regions where they are localized. The primary goal of this tool is to offer a relational system that allows mapping the microsatellites of bacterial species, all of them with more than one genome sequenced to infer their possible polymorphic character, in the context of genomic structure and thus providing a first approach to the putative role they perform from the functional point of view. The tool can be applied not only in taxonomical and epidemiological studies but in the detection of possible relationships of these sequences with the molecular functions, the biological processes and, as a last resort, the different forms of these species evolution. The web site offers the service of queries to the bacterial microsatellites database according to the related tables and its inherent attributes. It also has the typical services of this kind of site like: logging system, forum, polls, links and documentation about the employed methodology and the topic(AU)

Study of Event Database for Improving Efficiency and Reliability of Data Input to JACVSD / 日本心臓血管外科学会雑誌

The Japanese adult cardiovascular database (JACVSD) contains details of all adult cardiovascular surgeries performed in Japan. This database has the potential to make data from all of Japan available to the world in the future. However, it is time consuming to enter several items from an individual terminal for all cases ; adding further pressure to already busy routine work. In our facilities, an original system using Filemaker Pro has been developed and used since 2004. This system has various functions integrated into it, and currently, the input system of JACVSD has been added. As a result, it becomes possible to automatically enter more than half the data of JACVSD, and excellent results can be reported. Intellectual property rights have been owed by Nihon University since 2007.

<b>The Use of SS-MIX in Clinical Trials and Postmarketing Studies： From the View of Pharmaceutical Industries </b> / 薬剤疫学

Those of us in the pharmaceutical industry are in favor of using SS-MIX standardized storage to alleviate the burden on medical professionals. As previously suggested, in addition to the benefits of reducing study periods, supporting a variety of investigative research and safety measures, and obtaining more accurate data on disease states and treatments, actively using this kind of new technology is a societal imperative in an information-driven society. Possible practical uses include (1) general application in drug use surveillance and special drug use surveillance, (2) appropriate sampling surveys, (3) patient monitoring, (4) observational studies with controls, such as those using disease registries, and (5) reviewing the results of safety measures. However, there is the issue of regulatory interpretation and consensus, with debate on information protection, and the issue of social infrastructure. Therefore, industry, government, and academia must continue its active, cooperative discussion to enable true implementation of this technology. (Jpn J Clin Pharmacoepidemiol 2013; 18(1): 57-64)

Comportamiento general de los accidentes provocados por animales venenosos en Colombia, 2006-2010 / Overall pattern of accidents caused by poisonous animals in Colombia, 2006-2010

Objetivo El conocimiento parcial de estadísticas nacionales acerca de accidentalidad por animales venenosos, con distribución geográfica en Colombia, motiva el estudio de dichas circunstancias. El objetivo fue realizar una línea base de los accidentes por animales venenosos reportados de forma telefónica al Centro de Investigación, Gestión e Información Toxicológica de la Universidad Nacional de Colombia (CIGITOX), provenientes de todo el país, y cuyo registro se encontraba en bases de datos de los cinco años de funcionamiento del centro (2006-2010). Metodología Estudio descriptivo, retrospectivo, de los datos generados por CIGITOX en un período de tiempo de cinco años (2006-2010). El análisis estadístico se hizo en hojas de cálculo de Excel 2011. Resultados Se encontraron, reportados y atendidos, 1 783 casos de los cuales el 47 % correspondió a accidente ofídico (evento de notificación obligatoria para Colombia), 25 % por escorpiones y 11 % por arañas, seguidos de otros que tienen representación epidemiológica menor en los principales departamentos de ocurrencia que fueron Antioquia, Valle del Cauca y Cundinamarca. Discusión Se presenta una perspectiva general de la problemática que puede favorecer programas de salud pública para el mejoramiento de la capacidad de respuesta de las comunidades, instituciones y profesionales del sector salud.

Objective This study was motivated as only partial knowledge is available (regarding national statistics) about accidents caused by poisonous animals in Colombia. The study was aimed at establishing a base-line concerning accidents reported by phone to the Toxicology Management and Research Information Centre (CIGITOX) from all over Colombia; such data was taken from the centre's data-base following its five years of being in operation(2006-2010). Methods This was a descriptive, retrospective study, taking information from the CIGITOX database over a five-year period (2006-2010); Excel 2011was used for statistical analysis. Results The database contained 1,783 cases which had been reported and attended; 47 % concerned snake bite accidents (an obligatory report event in Colombia), 25 % scorpion stings and 11 % spider bites, followed by others having valuable epidemiologic representation in the main areas of occurrence, such as the Antioquia, Valle del Cauca and Cundinamarca departments. Discussion The data provided an overview of the situation which could lead to promoting public health program aimed at raising awareness in communities, institutions and healthcare professional's whilst enforcing their ability to respond effectively.

Construction of sharing type network resource data base for clinical skills teaching / 中华医学教育探索杂志

The construction of a network resource data base for clinical skill teaching aiming at sharing excellent teaching resources was completed by integrating all kinds of teaching resource including characters,eourseware,pictures,cartoons,videos and examination questions,etc.In view of the generally weak situation of the current domestic education resource data base construction,the contents,guiding ideology,principle,object,orientation,function and the management mechanism of the network resource data base construction were devised for clinical skills teaching.Suggestions for specific ideas and construction problems were proposed to promote the construction and optimization of the network resource database for clinical skills teaching.

Building and application of digital teaching data base of medical imaging / 中华医学教育探索杂志

This article utilizes the latest digitization development trend of medical imaging teaching to illustrate the value of digitization in medical imaging, which discusses the setting up meaning, establishing methods, management and application, etc. of digital teaching data base.

ATECOM, registro computarizado de pacientes incluidos en investigaciones de aterosclerosis en la comunidad / ATECOM, computed registry of patients participating in researches of atherosclerosis in community

Para facilitar las investigaciones de aterosclerosis se desarrolló una base de datos para pacientes incluidos en estas investigaciones en la comunidad que permitiera entrar, almacenar y recuperar información para su posterior procesamiento y centralización. El producto contó con panel de control principal y variados formularios que simplifican su manipulación. Su elaboración se llevó a cabo en 3 etapas: una de trabajo en grupo para seleccionar las variables y crear el modelo Entidad Relacional, otra para diseñar y montar el producto, y una última para validarlo. El producto se basó en el Modelo de Recolección del Dato Primario del Centro de Investigaciones y Referencia en Aterosclerosis de La Habana. Contó con facilidades de entrada y salida de información, y con posibilidades de extracción de datos según tipo de estudio y hacia otros sistemas para su posterior procesamiento estadístico. Se validó a través de la capacitación desarrollada a los matriculados en la carrera certificativa de Investigación en Aterosclerosis

To make research on atherosclerosis easier a data base, on patients of the community suffering from this disease, was implemented. This data base will allow collecting, saving and recovering information for its further processing and centralization. The developed product was under a main Control Panel and several forms which simplify its management. Its elaboration was done in three stages: The first stage was a group work to select the variables and to create a Relation Entity Model, a second stage to design and assemble the product and a last one to validate the product. The product was based on the Primary data Collection Model of the Havana Atherosclerosis Research and Reference Center (CIRAH). It allows the input and output of information and it includes possibilities to withdraw the data according to the type of study and it is also available to other systems for its statistics processing. It was validated through the training program provided to those in the Atherosclerosis Research Certified Studies

Sistema de vigilancia epidemiológica comunitaria bonis: estado actualy proyecciones futuras / Community epidemiological surveillance system bonis: current status and future projections

El sistema actual de vigilancia epidemiológica en la zona del Centro de Ayuda Mutua y Salud para Todos (CAMSAT) del Bañado Sur, de Asunción, se basa en la búsqueda rutinaria de posibles casos febriles mediante visitas domiciliarias, realizadas por las agentes comunitarias adscritas a la Unidad de Salud Familiar (USF). Cada una de las diezagentes comunitarias de CAMSAT tiene asignada 150 hogares, y los resultados de susvisitas domiciliarias quedan recogidos en planillas que se reportan mediante medios tradicionales (papel, correo interno, fax, etc.) a la DGVS del Ministerio de Salud. La consecuencia de este modo de trabajo es que muchas veces las acciones de bloqueo de la transmisión llegan tarde con el coste social y económico que ello significa. El sistema Bonis introduce la telefonía móvil como elemento catalizador para transformar la búsqueda rutinaria de posibles casos febriles en una acción proactiva, y también la utilización de tecnologías web y bases de datos para el registro de pacientes y su correspondiente seguimiento por el personal sanitario. La utilización de estas tecnologíasde la información y comunicación (TICs) transforman el sistema de vigilancia epidemiológica en un caso de estudio de e-Salud en Paraguay. Se describe el estado actual y proyecciones futuras del sistema de vigilancia epidemiológica comunitaria “Bonis”,que utiliza las TICs para prevenir, alertar, supervisar y controlar la expansión de síndromes febriles en un área de influencia del Hospital Barrio Obrero (HBO), en la Unidad de Atención Primaria en Salud del Centro de Ayuda Mutua y Salud para Todos, Asunción,Paraguay.

The current system of epidemiologic surveillance in the area of Mutual Aid Centre and Health for All (CAMSAT in Spanish) in the “Bañado Sur” in Asuncion is based on routine screening of possible febrile cases through home visits made by community agents fromthe Primary Health Care Unit (USF in Spanish). Each of the ten community agents are assigned to 150 households and the results of these home visits are recorded on sheets that are reported through traditional means (paper, internal mail, fax, etc.) to the DGVSof the Ministry of Health. The consequence of this working system is that often the blocking actions arrive late with the social and economic costs that this implies. The Bonis system uses the mobile phone as a catalyst to transform the routine screening ofpotential feverish cases in a proactive action and the web technology and databases for patient records and appropriate follow-up by health personnel. The use of theseinformation and communication technologies of (ICTs) transforms the Epidemiological Surveillance System in a study case of e-Health in Paraguay. This document describes the current status and future projections of the community epidemiological surveillancesystem Bonis which uses Information and Communication Technologies (ICTs) to prevent, warn, monitor and control the spread of febrile syndromes in a catchment area of Barrio Obrero Hospital (HBO), Unit of Primary Health Care Center Mutual Aid and Health for All, Asuncion, Paraguay.