ABSTRACT
Purpose: To study clinical efficacy of valganciclovir in cytomegalovirus retinitis (CMVR) in human immunodeficiency virus (HIV)?positive?positive patients in a tertiary care clinic in a developing nation. Methods: In a retrospective study, systemic and ocular records of HIV patients suffering from CMVR and treated with valganciclovir, were analyzed. Primary outcome measures were involvement of the other eye, incidence of retinal detachment, systemic involvement, and mortality encountered. Secondary outcome measures included change in BCVA. Results: Out of nine patients who were included, two patients developed CMVR in the other eye and only one patient (11.11%) developed retinal detachment during the course of the study. No patient developed any systemic manifestations or had mortality during the course of the study. The change in BCVA was not statistically significant. Conclusion: Use of oral valganciclovir showed good outcome and was found to be a better alternative compared to the use of intravitreal ganciclovir in the literature. Introduction of valganciclovir at an affordable price in developing nations can decrease disease burden
ABSTRACT
Background:The prevalence of childhood obesity (COB) in the developing world is currently high and is rising rapidly. Unlike developed countries, studies evaluating the association between parental socio-economic status (SES) and risk of COB in developing countriesare limited. Besides, the association varies across country and race/ethnicity and changes overtime. The aim of this study was to assess the association between parental SES and life style habits (LSHs) and risk of COB in Uyo, Southern Nigeria.Methods:Five hundred pupils and the corresponding number of parents were examined between April and September 2018 using socio-demographic/LSHs assessment questionnaire and body mass index (BMI) evaluation. Data analysis was performed and frequencies and percentages were computed. Associations between SES and LSHs of parents and risk of COW/COB were evaluated using multiple logistic regression analysis. Odds ratios and corresponding 95% confidence intervals were estimated.Results:The prevalence of COW and COB was3.4% and 16% respectively. The risk of COW/COB was higher among children whose parents had high level of education (OR=1.81, C.I=1.985-3.327,P=0.046), high level of income(OR=16.07, C.I=3.773-68.455,P=0.0001), employed(OR=1.138,C.I=0.157-12.057) and poor dietary habits. High level of physical activity of fathers and high income level of mothers decreased the risk of COW/COB Conclusion: High SES and poor LSHs of parents are associated with increased risk of COW/COB. Interventions necessary to reduce high prevalence of COW/COB in our cities and other developing countries should include among other risk factors parental SES and LSHs.