ABSTRACT
Objective To explore the prevalence and related factors of female sexual dysfunction(FSD) in women with diabetic.Methods Female Sexual Function Index(FSFI) was used to investigate the prevalence of FSD in 336 women with diabetes.Logistic analysis was conducted between diabetic women with FSD and without FsD for related factom of diabetic FSD.Results Two hundred and fourty-four patients were found to have FSD.The prevalence was 72.6% .The Logistic analysis showed that FSD was significantly relaed to diahetic course and diabetic neuropathy.Conclusion The prevalence of FSD in diabetic women is significandy greater than non-diabetic women.Diabetic course and diabetic neuropathy play an important role in the development of FSD in diabetic women.
ABSTRACT
Objective To study the role of gastric mitochondrial DNA cytochrome C oxidases (COX) subunit Ⅱ gene and its expression in diabetic gastric motility dysfunction. Methods Seventy Wister rats were randomly divided into 2 groups: diabetic group (STZ 60mg/Kg intraperitonealy) and control group. The changes in expressions of COX protein were assayed by Westernblot. Mitochondrial DNA COX mRNA was assayed with reverse-transcriptional polymerase chain reaction(RT-PCR). Cytochrome C oxidase activity was determined by ultraviolet spectrophotometer. Results Gastricelectric dysrythmia was more frequently delected in diabetic rats, and the COX activity in diabetic rats was 0.41?0.21/min, which was significantly lower than that in normal rats (0.78?0.37/min). The expression of gastrointestinal COX protein and COX gene in diabetic gastroparesis rats were markedly decreased compared with normal rats. Conclusion Cytochrome C oxidases activity was greatly reduced in diabetic rats. Diabetic gastroparesis was associated with down-regulation of the expression of gastrointestinal mtDNA encoding COX gene and protein. These changes might play a key role in pathogenesis of diabetic gastroparesis