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Hyperbaric oxygenation (HBO2) is a successful treatment of diabetic foot ulcerations. Research on the characterization of tissue by ultrasonography (CATUS) or by imaging (CATIM) has grown. We investigated the photographic pCATIM feasibility to quantitate HBO2 effects. Besides, we analyzed pre and post HBO2 treatment photographs quantitatively based on pixel brightnesses of gray-scale imaging versions. Grayscale Medians (GSM) for (1) entire ulceration, (2) inner core, (3) ulceration border, and (4) adjacent skin decreased from 92 to 77, 60 to 56, 105 to 101, and 105 to 90. Entire ulceration post-HBO2 pixel percentages were lower in the 112-153 intervals, 11% vs 29% (p = .0013 by Chi-square), and higher in the 41-111 brightness range, 87% vs 68% (p = .0008). A case report showed quantifiable relative changes detected by pCATIM post HBO2 treatment of diabetic foot ulceration. Further investigation may quantify brightness variabilities and/or specific GSM for ulceration and skin regions.
A oxigenioterapia hiperbárica (HBO2) tem sido um tratamento de sucesso para úlceras do pé diabético, enquanto cresce o número de pesquisas caracterizando o tecido por meio de ultrassonografia (Catus) ou imagem (Catim) sendo que a pCatim torna viável quantificar os efeitos da oxigenioterapia hiperbárica. Fotografias do pré e pós tratamento foram analisadas quantitativamente com base em brilhos de pixel de versões de imagens em escala de cinza. Houve redução das medianas da escala de cinza (gray scale medians GSM) para (1) ulceração inteira, de 92 para 77; (2) núcleo interno, de 60 para 56; (3) borda da ulceração, de 105 para 101; e (4) pele adjacente, de 105 para 90. Na úlcera completa, após a HBO2, as porcentagens de pixels foram menores nos intervalos 112-153 (11% contra 29%, p = 0,0013 por qui-quadrado) e maiores na faixa de brilho 41-111 (87% contra 68%, p = 0,0008). Um relato de caso demonstrou mudanças relativas quantificáveis detectadas por pCatim após o tratamento com HBO2 de uma úlcera do pé diabético, e investigações mais aprofundadas podem quantificar as variabilidades de brilho e/ou GSM específicas para cada ulceração e regiões da pele.
La oxigenación hiperbárica (HBO2) ha sido un tratamiento exitoso de las ulceraciones del pie diabético. Ha crecido la investigación sobre la caracterización de tejidos por ecografía (CATUS) o por imágenes (CATIM). Se investigó la viabilidad fotográfica de pCATIM para cuantificar los efectos de HBO2. Las fotografías anteriores y posteriores al tratamiento con HBO2 se analizaron cuantitativamente en función del brillo de los píxeles de las versiones de imágenes en escala de grises. Medianas de escala de grises (GSM) para (1) ulceración completa, (2) núcleo interno, (3) borde de ulceración y (4) piel adyacente disminuyeron de 92 a 77, 60 a 56, 105 a 101 y 105 a 90, respectivamente. En la ulceración completa, después de HBO2, los porcentajes de píxeles fueron más bajos en los intervalos 112-153, 11% vs 29% (p = .0013 por Chi-cuadrado) y más altos en el rango de brillo 41-111, 87% vs 68% (p = .0008). Un informe de caso demostró cambios relativos cuantificables detectados por pCATIM después del tratamiento con HBO2 de una ulceración del pie diabético. Una investigación adicional puede cuantificar las variaciones de brillo y o GSM específico para ulceraciones y regiones de la piel.
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Foot Ulcer , Diabetic Foot , Research Report , Hyperbaric OxygenationABSTRACT
Diabetes is a worldwide public health problem that seriously threats human health. Long-term metabolic disorders， as the main cause of multi-system complications and death in the later stage of diabetes， can cause multi-system damage， leading to chronic progressive lesions in the eyes， kidneys， nerves， heart， blood vessels and other tissues and organs， as well as functional decline and failure. The low risk of side effects and new treatment strategies remain an area to be explored in clinical treatment of diabetes. Salviae Miltiorrhizae Radix et Rhizoma （SM） is one of the commonly used herbs in traditional Chinese medicine （TCM）， with the main effect of activating blood circulation and removing blood stasis. In recent years， it has been found that SM shows good performance in lowering blood sugar and treating diabetes complications. Data mining information has also shown that the drugs of activating blood circulation and removing blood stasis are now common drugs in clinical treatment of diabetes， and SM has the highest use frequency， with significant curative effect. In addition， TCM is a kind of treatment with composite components and multiple targets， and so people are increasingly interested in its effective components and carry out extensive researches. This article summarized the experimental verification of SM extract and its components （tanshinone A， tanshinone B， tanshinone ⅡA， tanshinone I， protocatechuic aldehyde， polysaccharide， and total polyphenol acid） in various diabetes models in improving glucolipid metabolism， improving heart function in patients with diabetes， alleviating the motor and sensory deficits caused by diabetes， preventing the occurence of the diabetic retinopathy， recovery of liver and kidney structure and function damage in diabetic patients， and helping to resist high sugar-induced atrophic cavitation potential. It may inhibit hyperglycemia-induced vascular injury with polyol pathway activation， reduce the formation of advanced glycation end products， inhibit protein kinase C pathway activation and hexosamine pathway activation， and alleviate oxidative stress caused by excessive production of peroxides in mitochondrial electron transport chain during hyperglycemia to play a role of treatment， and provide reference for clinical application.
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: With the increasing morbidity of diabetes, diabetic complications are also on the rise. Diabetic retinopathy is one of the severe complications in the late-stage diabetes. As a common blindness disease in clinic, diabetic retinopathy treatment has been a research focus. The pathogenesis of diabetic retinopathy is affected by multiple factors, multiple links and multiple genes, but the specific mechanism is not clear and it lacks effective drugs. This paper reviews the pathogenesis and treatment of risk factors of diabetic retinopathy and wish to provide reference for clinical prevention and treatment of DR.
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Aims: To determine the relationship between the diabetic foot stages and the self-awareness about self-care of the feet in patients attending first level medical facility.Study Design:This is a descriptive, cross sectional study.Place and Duration of Study:This study was conducted in Unit Number 57 ofthe Family Medicine in the Mexican Institute of Social Security in Puebla, Mexico between January and June of 2017.Methodology:We included 360 patients whom we surveyed to correlate between the level of knowledge about self-care of the feet in diabetic patients and its stages. We used a questionnaire in which the variables included gender, age, level of education, occupation, marital status, number of years since they were diagnosed with diabetes mellitus type 2, stage of the diabetic foot and level of knowledge related to this entity. Descriptive statistics and X2were used.Original Research Article Results:We included 360 patients who met the inclusioncriteria. Their average age was 55.75years, the average number of years with the diagnosis of diabetes mellitus was 6.07.There was a significant statistic association between the level of knowledge and the stage of the diabetic foot P = .049 a value of P= .05 was considered statistically significant. Conclusion:There is an association between the stage of the diabetic foot and the knowledge about the self-care of the feet among patients.
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Objective: To screen the best compatibility proportion of total alkaloids of Coptidis Rhizoma and Notoginseng Radix et Rhizoma total saponins (HS composition)by uniform design and pharmacological model and to observe the effect on diabetic complications. Method: The total alkaloids of Coptidis Rhizoma and Notoginseng Radix et Rhizoma total saponins were used as the research objects, U6(62) table was choosed for grouping design.The content of triglyceride fasting blood-glucose (FBG), prothrombin time (PT) and active partial thromboplastin time (APTT) was chosen as index. The best dose ratio was obtained by multipleregression analysis. Rats with type 2 diabetes mellitus induced by high-fat diet combined streptozotocin were divided into blank group, model group, metformin group (150 mg·kg-1), HS composition group (total alkaloids of Coptidis Rhizoma 360 mg·kg-1+ Notoginseng Radix et Rhizoma total saponins 40 mg·kg-1). Rats were administered orally for 10 weeks.By observing the blood glucose, glucose tolerance,area under the curve (AUC), triglyceride (TG), high-density lipoprotein (HDL-C)and low-density lipoprotein (LDL-C), hemorheological indexes and pathological changes of pancreas, heart, kidney and retina in rats of each group, the effect of this composition on diabetic complications was verified. Result: Combination of 625 mg·kg-1 total alkaloids of Coptidis Rhizoma and 60 mg·kg-1 Notoginseng Radix et Rhizoma total saponins was the optimal dosage ratio of HS composition.The validation test showed that compared with blank group, the fasting blood glucose and lipid levels in the model group were significantly increased (PPPPPPPPPPPConclusion: The optimum compatibility dose of HS composition have a good therapeutic effect on diabetic complication rats induced by high-fat diet and streptozotocin.
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Introduction: An economic analysis was performed to estimate the annual cost of diabetes mellitus to Malaysia. Methods: We combined published data and clinical pathways to estimate cost of follow-up and complications, then calculated the overall national cost. Costs consisted of diabetes follow-up and complications costs. Results: Patient follow-up was estimated at RM459 per year. Complications cost were RM42,362 per patient per year for nephropathy, RM4,817 for myocardial infarction, RM5,345 for stroke, RM3,880 for heart failure, RM5,519 for foot amputation, RM479 for retinopathy and RM4,812 for cataract extraction. Conclusion: Overall, we estimated the total cost of diabetes as RM2.04 billion per year for year 2011 (both public and private sector). Of this, RM1.40 billion per year was incurred by the government. Despite some limitations, we believe our study provides insight to the actual cost of diabetes to the country. The high cost to the nation highlights the importance of primary and secondary prevention.
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Diabetes Mellitus , Health Care Costs , Health ExpendituresABSTRACT
At present,metabolic memory is a major obstacle hindering the effective control of diabetes.Controlling blood sugar level solely by drugs can not prevent multiple diabetic complications.Understanding the molecular mechanisms of mediating diabetic complications,therefore,will eliminate the "metabolic memory" effect.In this artical,the molecular mechanism of metabolic memory mediating diabetic complications and prospective treatment drugs were reviewed,which provides basis to the further research on prevention and treatment of metabolic memory.
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In a search for novel treatments for diabetic complications from natural resources, we found that the ethyl acetate-soluble fraction from the 80% ethanol extract of the leaves of Homonoia riparia has a considerable inhibitory effect on advanced glycation end product (AGE) formation. Bioassay-guided isolation of this fraction resulted in identification of 15 phenolic compounds (1 – 15). These compounds were evaluated in vitro for inhibitory activity against the formation of AGE. The majority of tested compounds, excluding ethyl gallate (15), markedly inhibited AGE formation, with IC₅₀ values of 2.2 – 89.9 µM, compared with that of the positive control, aminoguanidine (IC₅₀ = 962.3 µM). In addition, the effects of active isolates on the dilation of hyaloid-retinal vessels induced by high glucose (HG) in larval zebrafish was investigated; (–)-epigallocatechin-3-O-gallate (6), corilagin (7), and desmanthine-2 (11) significantly decreased HG-induced dilation of hyaloid–retinal vessels compared with the HG-treated control group.
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Diabetes Complications , Ethanol , Euphorbiaceae , Glucose , In Vitro Techniques , Natural Resources , Phenol , ZebrafishABSTRACT
Objective To investigate the clinical efficacy of auricular plaster therapy for depression in newly diagnosed type 2 diabetes.Methods Sixty patients with depression in newly diagnosed type 2 diabetes were randomly allocated to group A of 18 cases, broup B of 22 cases and group C of 20cases. In addition to conventional hypoglycemic treatment, group A received psychological intervention; group B, auricular plaster therapy; group C, oral administration of fluoxetine hydrochloride capsules. Pre-/post-treatment changes in fasting blood glucose, two-hour postprandial blood glucose, glycosylated hemoglobin and the Hamilton Depression Scale (HAMD) score were observed in the three groups after eight weeks of treatment. The clinical therapeutic effects were compared between the three groups.Results There were no statistically significant post-treatment differences in fasting blood glucose, two-hour postprandial blood glucose and glycosylated hemoglobin among the three groups (P>0.05). There was a statistically significant pre-/post-treatment difference in the HAMD score in the three groups (P<0.05). There was a statistically significant difference in the HAMD score between groups B and A at two, four, six and eight weeks after treatment (P<0.05), between groups B and C at two weeks after treatment (P<0.05) and between groups C and A at two, six and eight weeks after treatment (P<0.05). The total efficacy rate was 77.8% in group A, 90.9% in group B and 90.0% in the control group. There was a statistically significant difference in the total efficacy rate between group B or C and group A (P<0.05).Conclusion Auricular plaster therapy plus medication is an effective way to treat depression in newly diagnosed type 2 diabetes.
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OBJECTIVES: The objective of the present study was to identify the factors that affect screening for diabetic complications by sex in the community. METHODS: This study used individual-level data from the 2013 Community Health Survey (CHS) for 20,806 (male, 9,958; female, 10,848) adults aged 30 years or older who were diagnosed with diabetes. Community-level data for 253 communities were derived from either CHS or national statistics. A chi-square test and multilevel logistic regression analysis was performed. RESULTS: There were significant differences in the rate of screening for diabetic complications according to individual-level and community-level variables. In the multilevel analysis, the community-level variance ratio of the null model was 7.4% and 9.2% for males and females, respectively. With regard to community-level variables, males were affected by the city type, number of physicians, and their living environment, while females were affected by number of physicians, natural and living environments, and public transportation. CONCLUSIONS: The factors that influenced individual willingness to undergo screening for diabetic complications differed slightly by sex; however, both males and females were more likely to undergo screening when they recognized their health status as poor or when they actively sought to manage their health conditions. Moreover, in terms of community-level variables, both males and females were affected by the number of physicians. It is essential to provide sufficient and ongoing opportunities for education on diabetes and its management through collaboration with local communities and primary care medical centers.
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Adult , Female , Humans , Male , Community Health Planning , Cooperative Behavior , Diabetes Complications , Education , Health Surveys , Logistic Models , Mass Screening , Multilevel Analysis , Primary Health Care , TransportationABSTRACT
Objective To investigate the level of plasma malondialdehyde (MDA)and coenzyme Q10 (CoQ10)in patients with type 2 diabetes mellitus,diabetic leg ulcer(DLU).Methods The DLU group consisted of 15 patients with leg ulcers and type 2 diabetes mellitus (7 men and 8 women).The diabetes group consisted of 15 patients with type 2 diabetes mellitus (8 men and 7 women).Ten healthy individuals,age and sex matched with the patients,were used as a control group.Laboratory investigations in the form of glycosylated hemoglobin,plasma MDA and plasma CoQ10 were assessed for all patients and controls.Results The study revealed that in the diabetes group,especially in the DLU group,the MDA level [(7.07 ±3.15)μmol/L and (3.15 ±2.66)μmol/L]was signifi-cantly higher than control group [(4.28 ±0.41)μmol/L]and the index difference between them (F =104.675,P <0.01),while CoQ10 levels in the two groups data[(0.33 ±0.16)mg and (0.16 ±0.16)mg ]were significantly lower than the control group [(0.86 ±0.13)mg](F =46.709,P <0.05).Conclusion Type 2 diabetic patients, especially with DLU,are at increased risk of oxidative stress manifested by increased plasma MDA.
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Objective To observe the clinical efficacy of electroacupuncture plus puncturing the thirteen ghost points in treating diabetic gastroparesis.Method Sixty patients with diabetic gastroparesis were randomized into a treatment group and a control group, 30 in each group. The treatment group was intervened by electroacupuncture plus puncturing the thirteen ghost points, while the control group was by electroacupuncture alone. The clinical efficacies were then compared.Result The total effective rate was 93.3% in the treatment group versus 83.3% in the control group, and the difference was statistically significant (P<0.05). Conclusion Electroacupuncture plus puncturing the thirteen ghost points is an effective approach in treating diabetic gastroparesis.
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Mori Folium (mulberry leaves or the leaves of Morus alba) as one of Chinese materia medica and food raw materials, its research and application in the treatment of diabetes and diabetic complications have become an increasing concern to the majority of scientists. With deepening the basic research and industrial development of Mori Folium, the bioactive component groups and their action mechanisms of Mori Folium used for the prevention and treatment of diabetes and diabetic complication continue to be revealed. In this paper, based on the previous research, we summarize and analyze the understanding of domestic and foreign scholars about the pathogenesis of diabetes and the active component groups and their action mechanisms of Mori Folium for the prevention and treatment of diabetes and diabetic complication in recent years in order to provide the guidance for the further study and the reference for the development and utilization of Mori Folium resource.
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Background Diabetic retinopathy (DR) is a common ocular complication of diabetes,and its pathogenesis is associated with a variety of factors.c-Jun N terminal kinase (JNK),one of the genes involving in apoptosis,plays an important role in the pathology of diabetes,and relative research is catching increasing interests in recent years.Objective This study was to quantify the expression of JNK3 in retinas of DR murine.Methods Forty-eight SPF male C57BL/6 mice were randomly divided into the diabetes group and the normal control group.Diabetic mouse models were establishend by intraperitoneal injection of 1％ streptozocin (STZ) dissolved by sodium citrate buffer,and equvilant volume of sodium citrate buffer was used in the same way in the mice of the control mice.The left eyeballs were obtained 2,4,8 weeks after modeling and the retinas were collected.Real-time quantitaive PCR was perfored to detect the expression of JNK3 mRNA in retinas.The use and care of the experimental mice complied with the Administration of Experimental Animals in Kunming Medical College.Results Blood glucose levels were significantly higher in 2,4,8 weeks after modeling in the diabetic group compared with the normal control group (t=-5.675,-5.498,-5.347,all at P＜0.01).The relative expression levels of JNK3 mRNA (A value) in the retinas were significantly different between the groups at various time points (Fgroup =102.345,P＜0.05 ; Ftime =131.679,P＜ 0.05).The relative expression levels of JNK3 mRNA in the retinas were 3.21 ±0.14 and 5.43 ±O.37 in 4 and 8 weeks after modeling in the diabetic group,which were significantly elevated in comparison with the normal control group (2.54±0.42 versus 2.26±0.67) (t =4.073,23.399,both at P＜0.05).Compared with the second week and fourth week,the relative expression levels of JNK3 mRNA in the retinas in the eighth week were significantly raised in the diabetic group (t =10.756,16.857,both at P ＜ 0.05).Conclusions JNK3 expression in the retina upregulates in diabtic mice in a time-dependent manner.JNK3 is paopably involved in the pathogenesis and development of DR.
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Diabetic muscle infarction (DMI) is an uncommon complication in patients with diabetes and it tends to be underdiagnosed, or misdiagnosed, clinically. Recently, we experienced a case of recurrent diabetic muscle infarction that was unusual in that the patient was younger than other patients. The patient was a 21-year-old woman with a 9-year history of maturity-onset diabetes of the young (MODY) who was referred to our department complaining of pain and edema in her right thigh. Magnetic resonance imaging (MRI) showed an increased T2-weighted signal and edema in the affected muscle. The final diagnosis was DMI. However, when the patient had partially recovered and was receiving supportive care, she had a second attack on the other side of the same leg during her hospitalization, in spite of her blood glucose level being strictly controlled. We report the clinical characteristics and imaging findings of this patient with recurrent DMI.
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Female , Humans , Blood Glucose , Diabetes Complications , Diabetes Mellitus, Type 2 , Edema , Hospitalization , Infarction , Leg , Magnetic Resonance Imaging , Muscles , Recurrence , ThighABSTRACT
Connective tissue growth factor (CTGF) is a potent pro-fibrotic factor, which is implicated in fibrosis through extracellular matrix (ECM) induction in diabetic cardiovascular complications. It is an important downstream mediator in the fibrotic action of transforming growth factor beta (TGFbeta) and is potentially induced by hyperglycemia in human vascular smooth muscle cells (VSMCs). Therefore, the goal of this study is to identify the signaling pathways of CTGF effects on ECM accumulation and cell proliferation in VSMCs under hyperglycemia. We found that high glucose stimulated the levels of CTGF mRNA and protein and followed by VSMC proliferation and ECM components accumulation such as collagen type 1, collagen type 3 and fibronectin. By depleting endogenous CTGF we showed that CTGF is indispensable for the cell proliferation and ECM components accumulation in high glucose-stimulated VSMCs. In addition, pretreatment with the MEK1/2 specific inhibitors, PD98059 or U0126 potently inhibited the CTGF production and ECM components accumulation in high glucose-stimulated VSMCs. Furthermore, knockdown with ERK1/2 MAPK siRNA resulted in significantly down regulated of CTGF production, ECM components accumulation and cell proliferation in high glucose-stimulated VSMCs. Finally, ERK1/2 signaling regulated Egr-1 protein expression and treatment with recombinant CTGF reversed the Egr-1 expression in high glucose-induced VSMCs. It is conceivable that ERK1/2 MAPK signaling pathway plays an important role in regulating CTGF expression and suggests that blockade of CTGF through ERK1/2 MAPK signaling may be beneficial for therapeutic target of diabetic cardiovascular complication such as atherosclerosis.
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Animals , Humans , Rats , Aorta , Atherosclerosis , Butadienes , Cell Proliferation , Collagen , Connective Tissue , Connective Tissue Growth Factor , Diabetes Complications , Extracellular Matrix , Fibronectins , Fibrosis , Flavonoids , Glucose , Hyperglycemia , Muscle, Smooth, Vascular , Nitriles , Phosphotransferases , RNA, Messenger , RNA, Small Interfering , Transforming Growth Factor betaABSTRACT
It is evident that metabolic memory,whereby diabetic complications continue to develop and progress in individuals who returned to normal glycemic control after a period of transient hyperglycemia,has long lasting effects.Recent studies suggest that “metabolic memory” may be due to epigenetic changes in target oells.Understanding the molecular changes in chromatin structure and the functional relationship with altered signaling pathways is now considered to represent an important conceptual challenge to explain diabetes and the phenomenon of metabolic memory.Emerging evidences indicate that critical gene-activating epigenetic changes may confer future cell memories. Many experimental evidences show that histone acetyltransferases (HATs), histone deacetylases (HDACs),histone methyltransferases (HMTs),histone lysine demethylases (KDMs),and microRNAs play important roles in the epigenetic changes of several key genes related to diabetic complications. Transient hyperglycemia promotes gene-activating epigenetic changes and signaling events critical in the development and progression of diabetic vascular complications.Further characterisation of these glucose-induced epigenetic events and the identification of key enzymes involved will help us to develop new therapeutic strategies for diabetes and its complications.
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OBJECTIVE: This research aimed to evaluate the relationship of limited joint motion (LJM) and shoulder adhesive capsulitis with diabetic complications and related diseases in type II diabetic patients. METHOD: A cross sectional study in 155 type II diabetic patients was done. The presence of LJM and shoulder adhesive capsulitis was sought. The diseases closely related to diabetes were recorded. The patients were assessed for retinopathy, nephropathy, and neuropathy. RESULTS: The prevalence of LJM and shoulder adhesive capsulitis in type II diabetic patients was 32.3% and 29.7%, respectively. Development of LJM and shoulder adhesive capsulitis was correlated with age and duration of diabetes. Higher blood HbA1c level was noticed in mild and moderate degree of LJM. The prevalence of shoulder adhesive capsulitis was shown association with LJM. The prevalence of LJM was associated with a history of myocardial infarction and chronic diabetic complications. The prevalence of shoulder adhesive capsulitis was associated with retinopathy, carpal tunnel syndrome, and autonomic neuropathy. CONCLUSION: According to the results, around 30% of type II DM patients could have hand LJM and should adhesive capsulitis, which suggested more attention and effort to prevent the LJM and shoulder adhesive capsulitis were needed.
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Humans , Bursitis , Carpal Tunnel Syndrome , Diabetes Complications , Hand , Joints , Myocardial Infarction , Prevalence , ShoulderABSTRACT
Introducción: la diabetes mellitus es la más común de las enfermedades metabólicas en los seres humanos y una de las principales causas de morbilidad y defunción. El objetivo de este estudio es determinar si existe relación entre la información del paciente diabético sobre su enfermedad y la descompensación de su padecimiento. Material y métodos: se estudiaron 30 pacientes diabéticos descompensados, hospitalizados; se excluyeron aquellos que tuvieron motivos diferentes a la descompensación diabética y se eliminaron los que pasaron a estado crítico. Se utilizó el análisis estadístico descriptivo para las características de la población y de la enfermedad; así como prueba de significancia X: para analizar la información. Resultados: predominó el género femenino (57%), edad mínima de 31 años y máxima de 81 con una x 60.3 + 13.9; en la información del padecimiento 17% de los pacientes recibió información adecuada sobre la enfermedad y 83% información deficiente; lo cual mostró chi2=13.2p > 0.001 y una índice de confianza del 95% p < 0.05 siendo estadísticamente significativa. Discusión: la información que se otorga sobre diabetes Mellitus es deficiente en la mayoría de los pacientes diabéticos descompensados.
Objetive: to determine if there is a relation between the información given to diabetic patients about their illness and the presentation of complications metabolic control. Materials and methods: we studied 30 diabetic patients with complications of their illness hospitalizad in 1999. We excluded diabetic patiens who requered intensive care. We utilized descriptive statistical analysis for the characteristics of the population and the disease. We utilized the x2 to significance test. Results: 17% of the patients had get good information about their illness and 83% get deficient information about it. We get a X2 =13,2, P > 0.001 and a = 0.05 P < 0.05. It was statistic significant. Conclusion: the information about diabetes in complicated patients is almost deficient. This patients are obese and with a long evolution in their illness.