Publicação em inglês: um novo marco editorial dos Cadernos Ibero-Americanos de Direito Sanitário / Publication in English: a new editorial milestone for Cadernos Ibero-Americanos de Direito Sanitário / Publicación en Inglés: un nuevo hito editorial de los Cadernos Ibero-Americanos de Direito Sanitário

Os avanços tecnológicos impactaram diretamente a forma como a ciência é comunicada, reduzindo fronteiras e conectando indivíduos, mas a barreira linguística ainda persiste como um obstáculo significativo para a colaboração entre pesquisadores e a disseminação do conhecimento. Publicações em inglês têm alcance ampliado, viabilizando a difusão dos resultados dos estudos e pesquisas dos periódicos nacionais. Os Cadernos Ibero-Americanos de Direito Sanitário (CIADS), na esteira dessa vanguarda, passam a publicar seus artigos originais, resenhas e comunicações breves em inglês, sem custo para o autor, além da manutenção do idioma original. Este importante passo marca uma inovadora trajetória editorial do periódico, rumo à sua internacionalização.

Los avances tecnológicos han impactado directamente la forma en que se comunica la ciencia, reduciendo fronteras y conectando individuos, pero la barrera lingüística aún persiste como un obstáculo significativo para la colaboración entre investigadores y la difusión del conocimiento. Las publicaciones en inglés han ampliado su alcance, facilitando la difusión de los resultados de estudios e investigaciones en revistas nacionales. Siguiendo esta vanguardia, los Cadernos Ibero-Americanos de Direito Sanitário (CIADS) ahora publicarán sus artículos originales, reseñas y comunicaciones breves en inglés, sin costo para el autor, además de mantener el idioma original. Este importante paso marca una trayectoria editorial innovadora del periódico hacia su internacionalización.

Technological advances have directly impacted the way science is communicated, reducing borders and connecting individuals, but the language barrier still persists as a significant obstacle to collaboration between researchers and the dissemination of knowledge. Publications in English have a wider reach, making it possible to disseminate the results of studies and research in national journals. Cadernos Ibero-Americanos de Direito Sanitário (CIADS), in the wake of this vanguard, is now publishing its original articles, reviews and short communications in English, at no cost to the author, in addition to maintaining the original language. This important step marks the journal's innovative editorial path towards internationalization.

Análise das produções científicas sobre atenção integral à saúde do homem: revista Nursing brasileira / Analysis of scientific productions on comprehensive care for men's health: Brazilian Nursing magazine

Objetiva-se analisar as produções cientificas sobre a atenção integral da saúde do homem na Revista Nursing brasileira, São Paulo. Método: trata-se de uma revisão integrativa de literatura, utilizando as bases de dados LILACS e BDENF, o corte epistemológico foi de 2009 a 2019, a amostra final constituiu-se de 10 artigos. Resultados: os dados analisados foram divididos a partir de associações temáticas, em quatro categorias: acesso e acolhimento; saúde sexual e saúde reprodutiva; doenças prevalentes na população masculina e prevenção de violência e acidentes. Conclui-se que o cuidado integral a saúde do homem, e colocá-los como sujeito do cuidado, com autonomia, independência e responsabilidade social.(AU)

The objective is to analyze scientific productions on comprehensive men's health care in the Brazilian Nursing Journal, São Paulo. Method: This is an integrative literature review, using the LILACS and BDENF databases, the epistemological cut was from 2009 to 2019, the final sample consisted of 10 articles. Results: The data analyzed was divided into four categories based on thematic associations: access and reception; sexual health and reproductive health; prevalent diseases in the male population; and prevention of violence and accidents. The conclusion is that comprehensive care for men's health should place them as the subject of care, with autonomy, independence and social responsibility.(AU)

El objetivo es analizar la producción científica sobre atención integral a la salud masculina en la Revista Brasileña de Enfermería, São Paulo. Método: Se trata de una revisión bibliográfica integradora, utilizando las bases de datos LILACS y BDENF, el corte epistemológico fue de 2009 a 2019, la muestra final constó de 10 artículos. Resultados: Los datos analizados se dividieron en cuatro categorías a partir de asociaciones temáticas: acceso y acogida; salud sexual y salud reproductiva; enfermedades prevalentes en la población masculina; y prevención de violencia y accidentes. Se concluye que la atención integral a la salud del hombre debe colocarlo como sujeto de cuidados, con autonomía, independencia y responsabilidad social.(AU)

Discrimination of the Governance Principles of Science and Technology Ethics and Dissemination of Ideas / 中国医学伦理学

Ethical governance is inherent in responsible research and innovation. The Opinions on Strengthening Ethical Governance of Science and Technology puts forward five ethical principles: promoting human well-being, respecting the right to life, adhering to fairness and justice, reasonably controlling risks and maintaining openness and transparency. This paper interpreted the ideas, key points and difficulties of these five ethical principles. Three suggestions were put forward to strengthen the ethics education of science and technology: first, optimize the curriculum of science and technology ethics for related majors in colleges and universities, and help young students understand ethical principles and establish the correct ethics view of science and technology; second, colleges and universities should carry out education and training for teachers, researchers, managers and members of ethics committees, and actively explore scientific research ethics training and effect evaluation; third, the professional courses offered by college teachers should be organically integrated with the ideological and political content of the courses to play a warning role.

Mes de la Ciencia: estrategia para el conocimiento y la investigación

El Mes de la Ciencia surge como idea para socializar y divulgar las investigaciones y el nivel de actualización sobre los principales problemas de salud que afectan a la población matancera. Expone el nivel científico de las diferentes especialidades que ofrecen servicio en las instituciones de salud; permite la interdisciplinariedad entre ellas; motiva a los estudiantes del pregrado y resulta una fuente de gestión del conocimiento para el educando del posgrado; ofrece soluciones para los desafíos de la vida cotidiana y el manejo de las principales entidades que son atendidas en las instituciones, y permite el crecimiento profesional y el intercambio entre profesionales del país y del extranjero. Los autores se proponen mostrar los primeros resultados que ha tenido el Mes de la Ciencia a partir de su implementación. Estos están relacionados con el número considerable de conferencias magistrales y talleres impartidos, del incremento de participantes por mes y del nivel de satisfacción por eventos recogido por los principales actores. Aún más, se ha transformado de evento interhospitalario a uno con carácter provincial, con participación nacional e internacional y con alta aceptación por la comunidad científica, lo que le ha merecido el reconocimiento de los directivos provinciales y del ministro de Salud Pública.

Science month arises as an idea to socialize and disseminate research and the level of updating on the main health problems affecting the population of Matanzas. It exposes the scientific level of the different specialties that offer services in health institutions; it enables interdisciplinarity between them; motivates undergraduate students and is a source of knowledge management for postgraduate students; it offers solutions for the challenges of daily life and the management of the main entities that are served in the institutions, and allows the professional growth and interchange between professional in the country and abroad. The authors intend to show the first results the Science Month has had since its implementation. These are related to the considerable number of keynote conferences and workshops given, the increase in participants per month and the level of satisfaction per events collected by the main actors. Even more, it has been transformed from an inter-hospital event to one of a provincial character, with national and international participation, and with high acceptance by the scientific community, which has earned it the recognition of the provincial management staff and the minister of Public Health.

Qualidade das informações sobre lipoaspiração para o público leigo: Uma revisão de escopo / Quality of information about liposuction for the lay public: A scoping review

Introdução: Esta revisão de escopo tem por objetivo analisar a qualidade das informações sobre lipoaspiração para o público leigo. Método: Foi realizada busca na literatura no período de 18 de novembro a 12 de dezembro de 2021 nas seguintes plataformas de base de dados: Medline, Cochrane, LILACS, Embase e BVS. A estratégia de busca envolveu a combinação de vários descritores. Três investigadores independentes leram o resumo dos estudos que foram obtidos usando a estratégia de busca para avaliar aqueles que preenchiam os critérios de elegibilidade. Resultados: Inicialmente, foram levantados 33 artigos utilizando a estratégia de busca. Dentre esses, 23 estudos foram excluídos após a leitura dos resumos e avaliação dos critérios de elegibilidade, por não possuírem desfechos de interesse ao tema proposto. Assim, dez estudos preenchiam os critérios de inclusão, sendo nove estudos transversais e uma revisão de literatura. Dentre os dez artigos incluídos, nove relatam que as informações sobre lipoaspiração são precárias e imprecisas. Conclusão: O conteúdo sobre lipoaspiração disponibilizado ao público leigo por meio da Internet é, na sua maioria, insatisfatório.

Introduction: This scoping review aims to analyze the quality of information about liposuction for the lay public. Method: A literature search was carried out from November 18 to December 12, 2021, on the following database platforms: Medline, Cochrane, LILACS, Embase, and VHL. The search strategy involved the combination of several descriptors. Three independent investigators read the abstract of studies obtained using the search strategy to evaluate those that met the eligibility criteria. Results: Initially, 33 articles were collected using the search strategy. Among these, 23 studies were excluded after reading the abstracts and evaluating the eligibility criteria, as they did not have outcomes of interest to the proposed topic. Thus, ten studies met the inclusion criteria, nine of which were cross-sectional and one literature review. Among the ten articles included, nine report that information about liposuction is poor and inaccurate. Conclusion: The content on liposuction made available to the lay public via the Internet is, for the most part, unsatisfactory.

Consolidation of the Journal Investigación y Educación en Enfermería as a Publication with Impact on the Dissemination of Nursing Knowledge

Almost 14 years ago, Dean Beatriz Elena Ospina Rave entrusted me with the direction of the IEE Journal, given the leave of absence taken by the then director, María del Pilar Pastor, who had been named Secretary of Health of the Municipality of Medellín. Meeting this responsibility represented a great academic and professional challenge because it was a scientific publication of the highest quality in the area of Nursing, recognized in Colombia and Latin America. I received a journal with 26 years of uninterrupted edition and which already had three years in category A2 in the PUBLINDEX by COLCIENCIAS, hence, I had the commitment to lead the preparation of the publication to ascend to the long-awaited maximum A1 category, for which it was "only" necessary to meet the most complex criterion to obtain: achieve indexing in Medline, or in at Consolidation of the Journal Investigación y Educación en Enfermería as a Publication with Impact on the Dissemination of Nursing Knowledge*Invest Educ Enferm. 2023; 41(3): e01least one of the bibliographic citational bases, like Elsevier's Scopus or in the Web of Science, now Clarivate.

Impacto de una intervención educativa en el conocimiento de la prevención de la neoplasia del cuello uterino en estudiantes de enfermería y sus familias / Impact of an educational intervention on the knowledge of cervical cancer prevention in nursing students and their families

Resumen El objetivo fue evaluar el impacto de una intervención educativa en el conocimiento de la prevención de la neoplasia del cuello uterino en un grupo de estudiantes de enfermería y sus familias bajo el modelo de Nola Pender. El método fue un estudio cuasi-experimental con muestra no probabilística; se evaluó el conocimiento sobre la prevención y el control de la neoplasia del cuello uterino antes y después de una intervención educativa utilizando la encuesta validada por la Dra. Dina Rubio en 2009 con su previo consentimiento. La información fue tabulada mediante una hoja de cálculo del programa Microsoft Excel; se calcularon frecuencias específicas y frecuencias absolutas, y para el análisis se tomó el modelo de Nola Pender. Los resultados desde el punto de vista estadístico fueron que hay una información instalada en la estructura mental de las participantes sobre lo que es, implica y comporta como riesgo la neoplasia del cuello uterino. La percepción que está en el fondo de sus creencias denota un nivel favorable de conciencia y claridad, lo que posibilita que en las prácticas de autocuidado y la aplicación de la citología se reconozca frecuencia de uso, regularidad en el tiempo y atención a los resultados. En conclusión, al evaluar el impacto de la intervención educativa a través del modelo de Nola Pender se encontraron cambios en los conocimientos y un modelo ideal para utilizarse en grupos poblacionales heterogéneos en edades, niveles educativos, formación profesional y hábitos sexuales, porque integra la experiencia personal, el entorno y las prácticas de salud como tres elementos sin los cuales no es posible practicar el autocuidado y la cultura de intervención.

Abstract A large number of factors influence the level of information that people may have regarding cervical cancer and the way to prevent it, since education is not only provided by health personnel but also by the family. When making important decisions regarding self-care, people must have effective sex education, in which protection is of vital importance, since misinformation is one of the main factors that promotes cervical cancer. The objective of this study was to evaluate the impact of an educational intervention on the knowledge of cervical cancer prevention in a group of nursing students and their families under the Nola Pender model. The method used in the study was a quasi-experimental, non-probabilistic sample; the knowledge about cervical cancer prevention and control was evaluated before and after the intervention, using the survey validated by Dr. Dina Rubio in 2009 (with her consent). The information was included in a Microsoft Excel spreadsheet: the items were placed in columns and the subjects were included in the rows. Specific frequencies and absolute frequencies were calculated, the Nola Pender model was used for the analysis. The units of analysis were selected manually or randomly and these selections do not depend on probability but are generated based on the criteria of the researcher or the specific needs of the research. From a statistical point of view, information about what cervical cancer is, what it implies and how it behaves as a risk is engrained in the mental structure of the participants. To these implications of a technical and methodological nature, others of a structural and conceptual nature are added to build an integrative analysis of the results obtained in the field work. In this case, they include opinions, appraisals, judgments, and evaluations about cervical cancer. This research was organized in the following stages: (1) Evaluation of prior knowledge on cervical cancer prevention and control. The starting point of the investigation was the recognition that the participating women had a basic conceptual scaffolding, acquired through their own experience and self-training or by going to sources such as academia, social networks, specialized magazines, health institutions, medical staff and other specialists who help in the creation of an important background to consolidate an individual perspective. (2) Application of an educational intervention. In this stage, designed workshops were implemented and evaluated by the students with the advice of a teacher, and included the following topics: general concepts, signs and symptoms, associated risk factors, screening techniques, benefits, and exam precautions. The students contributed a theoretical, methodological and evaluative foundation to the design of each workshop, considering the expected training objectives, the characteristics included in its development, and a diversity of pedagogical actions that guarantee the efficiency of the transmitted message. (3) Reevaluation of the knowledge acquired. By applying a post-test, the knowledge acquired during the implementation of the workshops was recovered and resized. In this stage, the variability of the responses measured the transforming effect of the training, either by improving the knowledge acquired or by introducing new knowledge into the participant's cognitive model. The perception that participants have about self-care practices is linked to their beliefs, denoting a favorable level of awareness and clarity, which makes it possible for the application of cytology to recognize the frequency of use, regularity over time, and attention to the results. In conclusion, when evaluating the impact of educational intervention through the Nola Pender model, changes in knowledge were found. Results also indicate that this is an ideal model for employees in heterogeneous popu lation groups in ages, educational levels, professional training, and sexual habits, because it integrates personal experience, the environment and health practices as three elements without which it is not possible to practice self-care and the culture of intervention.

Impacto da disseminação de informação sobre endometriose no autocuidado de adolescentes de escola pública / Impact of dissemination of information about endometriosis on self-care of public school adolescents

Objetivo: Averiguar o conhecimento das adolescentes sobre endometriose, que é uma doença estrogênio-dependente, podendo ser progressiva, e que se caracteriza pela presença do tecido endometrial fora do útero. Estima-se que a endometriose acometa cerca de 10% das mulheres em idade reprodutiva, sendo 4% a 17% das adolescentes. Métodos: A pesquisa foi desenvolvida com adolescentes estudantes do terceiro ano do ensino médio de escolas estaduais do município de Avaré (São Paulo) de forma descritiva, exploratória e quali-quantitativa, em três etapas: aplicação de questionário, realização de palestra e nova aplicação de questionário. Participaram quatro escolas, totalizando 80 adolescentes participantes na primeira fase e 48 adolescentes na terceira fase. Resultados: Houve aumento de 21,35 vezes no número de adolescentes que se beneficiaram dos conhecimentos gerados pelas palestras, além da replicação da informação para terceiros, possivelmente aumento no número de mulheres que tomaram conhecimento sobre o que é endometriose. Conclusão: Verificou-se que a aplicação de palestras informativas sobre sinais e sintomas de endometriose aumentou o grau de conhecimento de adolescentes entre 16 e 17 anos de escola pública.

Objective: To investigate the knowledge of adolescents about Endometriosis, which is a progressive, estrogen/dependent disease, which can be progressive and which is characterized by the presence of endometrial tissue outside the uterus. It is estimated that it affects about 10% of women of reproductive age, of which 2%-4% are postmenopausal, with or without hormonal treatment, and 4% to 17% of adolescents. Methods: The research was carried out with adolescent students in the 3rd year of high school from state schools in the city of Avaré (São Paulo) in a descriptive, exploratory and qualitative-quantitative manner in three stages: application of a questionnaire, holding a lecture and a new application of quiz. Four schools participated, totaling 80 adolescents participating in the first phase and 48 adolescents in the third phase. Results: There was a 21.35-fold increase in the number of adolescents who benefited from the knowledge generated by the lectures, in addition to the replication of information to third parties, possibly an increase in the number of women who learned about what endometriosis is. Conclusion: It was found that the application of informative lectures on signs and symptoms of endometriosis increased the level of knowledge of adolescents between 16 and 17 years of age in public school.

Pineocytoma with malignant transformation to pineal parenchymal tumor with intermediate differentiation and leptomeningeal dissemination after subtotal tumor resection and adjuvant radiotherapy

Pineocytoma is a rare tumor. It is rare for pineocytoma to present as leptomeningeal metastasis. We present a rare case of pineocytoma with malignant transformation and leptomeningeal metastasis after subtotal tumor resection and adjuvant radiotherapy. This case was a 58-year-old male with an unsteady gait for 2 months. Enhanced brain magnetic resonance imaging revealed a heterogeneous mass involving the pineal region. The initial pathological diagnosis of pineocytoma was confirmed after subtotal tumor resection. Two years after adjuvant radiotherapy to the primary site, the magnetic resonance imaging showed C2 and T2 metastatic lesions, with the final pathological diagnosis being pineal parenchymal tumor (PPT) with intermediate differentiation after the removal of T2 intramedullary tumor. After that adjuvant radiotherapy at the cervical and thoracic spinal cord was completed. There was no recurrence of the tumor 1 year after the radiotherapy. We report a rare case of pineocytoma with malignant transformation to PPT with intermediate differentiation and leptomeningeal dissemination.

Health Education: Development and Validation of a Guideline for Oral Hygiene of Children Undergoing Cancer Treatment

Children with cancer commonly present oral health impairments due to lack of orientation about oral hygiene, which should be directed to caregivers since they are essential in this process. We developed and validated a guideline directed to caregivers for oral hygiene of children with cancer. This exploratory methodological study developed an educational guideline in three stages: analysis of oral health of children attended at the oncology service; literature review and development of the guideline for oral hygiene; semantic, appearance, and content validation by dentists, education professionals, and the target population. We used the Educational Content Validation Instrument in Health, and agreements of ≥ 80 % among evaluators were considered to maintain or modify the assessed items. Professionals and caregivers were mostly female; the latter were predominantly mothers with low educational level from inland areas of Pernambuco state (Brazil). Most professionals had more than ten years of experience in pediatric dentistry. Agreement was > 80 % in all items. The content of the guideline for oral hygiene was valid and relevant to be used in children with cancer.

Los niños con cáncer comúnmente presentan afecciones en la salud bucal por falta de orientación sobre la higiene bucal, la cual debe ser dirigida a los cuidadores ya que son fundamentales en este proceso. Desarrollamos y validamos una guía dirigida a cuidadores para la higiene bucal de niños con cáncer. Este estudio metodológico exploratorio desarrolló una directriz educativa en tres etapas: análisis de la salud bucal de los niños atendidos en el servicio de oncología; revisión de la literatura y desarrollo de la guía para la higiene oral; validación semántica, de apariencia y de contenido por parte de odontólogos, profesionales de la educación y población objetivo. Se utilizó el Instrumento de Validación de Contenido Educativo en Salud, y se consideraron acuerdos ≥ 80 % entre evaluadores para mantener o modificar los ítems evaluados. Los profesionales y cuidadores eran en su mayoría mujeres; estas últimas eran predominantemente madres con bajo nivel educativo del interior del estado de Pernambuco (Brasil). La mayoría de los profesionales tenían más de diez años de experiencia en odontopediatría. La concordancia fue > 80 % en todos los ítems. El contenido de la guía de higiene oral fue válido y pertinente para ser utilizado en niños con cáncer.

Fontes de informações confiáveis sobre Covid-19 entre usuários da Estratégia Saúde da Família / Reliable sources of information about COVID-19 among users of the Family Health Strategy

Analisar o acesso às fontes confiáveis de informações sobre Covid-19 por usuários na Estratégia Saúde da Família. Estudo transversal e descritivo realizado com 400 usuários atendidos na Estratégia Saúde da Família, no período de janeiro a setembro de 2021, em um município no sul do Mato Grosso. Utilizou-se um questionário estruturado, contendo dados sociodemográficos e de acesso às informações. Foram realizadas análises estatísticas por meio do software Stata, versão 16.0. Observou-se que pessoas mais jovens, de 18 a 39 anos, tendem a confiar mais nas mídias sociais (p= 0,342) e nos profissionais da saúde (p<0,001), enquanto adultos de 40 a 59 anos apresentaram maior confiança nas mídias tradicionais (p<0,001). Mulheres confiam mais que homens em todas as fontes de informações apresentadas nesse estudo. A confiabilidade da população adulta às diferentes fontes de informações acerca da Covid-19 está relacionada a fatores como idade, sexo e renda familiar.

To analyze access to reliable sources of information about COVID-19 by users in the Family Health Strategy. Cross-sectional and descriptive study carried out with 400 users assisted in the Family Health Strategy, from January to September 2021, in a municipality in the south of Mato Grosso. A structured questionnaire was used, containing sociodemographic data and access to information. Statistical analyzes were performed using the Stata software, version 16.0. It was observed that younger people, aged 18 to 39 years, tend to trust social media more (p= 0.342) and health professionals (p<0.001), while adults aged 40 to 59 years showed greater trust in the media traditional (p<0.001). Women trust more than men in all sources of information presented in this study. The reliability of the adult population to the different sources of information about COVID-19 is related to factors such as age, gender, and family income.

Bacterial dissemination in Mycobacterium tuberculosis by CD+ T-cells & proinflammatory cytokines

Background & objectives: As CD4+ and CD8+ T lymphocyte numbers decline, the conventional, localized forms of tuberculosis shift to the atypical, disseminated forms. Variations in lymphocyte and immune cell expression levels affect how tuberculosis manifests in disseminated forms. Understanding the relationship between lymphocyte counts (CD4+ and CD8+) and pro-inflammatory cytokines such as tumour necrosis factor-alpha, interleukin-12 and interferon, we may therefore be able to shed light on how infections spread and suggest potential biomarkers for these immune factors. Methods: In this study, 15 guinea pigs were infected with Mycobacterium tuberculosis (M.tb) H37Rv strain and grouped into three groups of five each for further investigation. Serum samples and bronchoalveolar lavage (BAL) fluid were examined for the expression of pro-inflammatory cytokines and T-cell subsets in guinea pigs infected with pulmonary tuberculosis and disseminated tuberculosis. Results: We found that M.tb escapes macrophages due to pro-inflammatory cytokine dysregulation. Despite the protective immunity created by T-cells and cytokines, M.tb bacilli may spread to other organs due to inflammation induced by these immune components. A high number of T-cells and stimulated cytokine production are involved in triggering inflammation after necrotic tissue develops and tuberculosis spreads. Interpretation & conclusions: Our findings imply that increased bacilli in the spleen at the 8th wk of infection may be caused by the overexpression of CD4+ T-cell lymphocyte subsets and cytokines that generated inflammation during the 4th wk of infection. This is a pilot study with a small sample size and less assertive inference. Larger studies would be helpful to validate the results of the present investigation.

Credibility, accuracy and readability of patient-oriented information about low back pain on Brazilian websites: a mixed-method review / Credibilidade, acurácia e legibilidade das informações orientadas ao paciente sobre dor lombar em sites brasileiros: uma revisão de método misto

ABSTRACT BACKGROUND AND OBJECTIVES: Low-quality online health-related content may lead to inefective or harmful decision-making from patients related to their healthcare. The aim of this study was to evaluate the credibility, accuracy and readability of web-based content on Brazilian websites. METHODS: This is a mixed-method review with exploratory sequential design. Google was selected as the search engine for retrieving web-information about low back pain (LBP) in Brazilian websites. We assessed the URL on three domains: credibility, accuracy, and readability. Qualitative analysis of each URL was performed in three steps: (1) organization into thematic units; (2) data exploration; and (3) interpretation of the data and summarization. RESULTS: Credibility was assessed in 135 URLs, 72 (53%) URLs had no authorship, 119 (88%) did not mention the sources of their information, none presented a declaration of conflict of interest or the declared source of funding, 76 (56%) URLs present the date of creation. Accuracy was assessed in 121 URLs and none fully adhered to the guidelines. Readability was assessed in 128 and texts were classified as "very easy" or "easy" to read. Five main themes emerged in the qualitative analysis: (1) Explanations and causes for low back pain, (2) diagnosis, (3) recommendation about treatment, (4) recommendation for coping and self-management, and (5) lifestyle factors. CONCLUSION: Content analysis of web-based searches on the Brazilian Portuguese language demonstrated low credibility standards, mostly inaccurate information, and moderate-high readability levels about low back pain.

RESUMO JUSTIFICATIVA E OBJETIVOS: O conteúdo on-line relacionado à saúde quando apresenta baixa qualidade pode levar a tomadas de decisão ineficazes ou prejudiciais por parte dos pacientes. O objetivo deste estudo foi avaliar a credibilidade, acurácia e legibilidade do conteúdo em portais brasileiros. MÉTODOS: Esta é uma revisão de método misto com design sequencial exploratório. O Google foi selecionado como o mecanismo de busca para recuperar informações da web sobre dor lombar em sites brasileiros. Avaliamos os URL em três domínios: credibilidade, acurácia e legibilidade. A análise qualitativa de cada URL foi realizada em três etapas: (1) organização em unidades temáticas; (2) exploração de dados; e (3) interpretação dos dados e resumo. RESULTADOS: A credibilidade foi avaliada em 135 URLs, 72 (53%) URLs não tinham autoria, 119 (88%) não mencionavam as fontes de suas informações, nenhuma apresentava declaração de confito de interesse ou fonte de fnanciamento declarada, 76 (56%) URLs apresentam a data de criação. A acurácia foi avaliada em 121 URLs e nenhuma aderiu totalmente às diretrizes. A legibilidade foi avaliada em 128 e os textos foram classificados como "muito fáceis" ou "fáceis" de ler. Cinco temas principais emergiram na análise qualitativa: (1) Explicações e causas da dor lombar, (2) diagnóstico, (3) recomendação sobre tratamento, (4) recomendação para enfrentamento e autogerenciamento e (5) fatores de estilo de vida. CONCLUSÃO: A análise de conteúdo de pesquisas baseadas na web, no idioma português do Brasil, demonstrou baixos padrões de credibilidade, acurácia e níveis moderados a altos de legibilidade sobre a dor lombar.

Dissemination mechanism of blaKPC-2 among carbapenem-resistant Klebsiella pneumoniae strains / 中华微生物学和免疫学杂志

Carbapenem-resistant Klebsiella pneumoniae (CRKP) is highly prevalent and poses a great health challenge due to the lack of effective treatments. Klebsiella pneumoniae carbapenemase-2 (KPC-2), encoded by blaKPC-2 gene, is one of the major contributors to carbapenem resistance in CRKP. In China and other Asian regions, Tn1721 and plasmid IncFⅡ are the main vectors for blaKPC-2 transfer between Kpn ST11 strains, which lack clustered regularly interspaced short palindromic repeats (CRISPR) and restriction-modification (R-M) systems. The structure of transposons has a significant impact on the transposition frequency of blaKPC-2, which may be related to the different transposition patterns of transposons. The prevalence advantage of blaKPC-2 in Kpn ST11 strains is highly associated with the immune deficiency in Kpn ST11. By acquiring a re-engineered CRISPR-Cas3 system via conjugation, the high-risk IncFⅡ plasmid can be successfully cleaved and ST11 CRKP can regain antibiotic sensitivity, which provides a promising approach for clinical treatment and prevention of CRKP.

Research on the Communication Strategies for Shaanxi Traditional Chinese Medicine Culture Based on the "5W" Model / 中国医学伦理学

Traditional Chinese medicine (TCM) is a treasure of ancient Chinese science and a key to unlocking the rich heritage of Chinese civilization. Report of the 20th National Congress of the Communist Party of China and the important speech by General Secretary Xi Jinping at the symposium on cultural inheritance and development provide scientific guidance for accelerating the dissemination of TCM culture in Shaanxi. Starting from the value implications of strengthening the dissemination of TCM in Shaanxi, Taking Harold Lasswell’s "5W" theory as the analytical framework and the problems of weak leadership of communication subjects, insufficient scientific content, low flexibility of communication channels, weak targeting of communication audiences, and insufficient integration of communication effects in the dissemination process of TCM culture in Shaanxi, this paper proposed strategies for the dissemination of Shaanxi TCM culture from five aspects, including strengthening dissemination subjects, optimizing communication content, diversifying communication channels, segmenting communication audiences, and enhancing communication effectiveness.

Translation and cross-cultural adaptation of the knowledge translation planning template for the brazilian context / Traducción y adaptación intercultural de la plantilla de planificación para la traducción de conocimiento al contexto brasileño / Tradução e adaptação transcultural da ferramenta knowledge translation planning template para o contexto brasileiro

ABSTRACT Objective: to translate, cross-culturally adapt, and validate the content of the Knowledge Translation Planning Template, a research dissemination planning tool, into Brazilian Portuguese. Method: this is a methodological study, sequentially divided into six stages: initial translation, translation synthesis, back-translation, judges' committee, pre-test, and approval of the adapted version by the instrument author. The judge's committee assessed content validity using the modified Kappa and Content Validity Index. The test was conducted with teachers and students from a Federal University of Santa Catarina graduate program. Results: the process of translating and back-translating the tool showed no discrepancies in terms of meaning. The committee was composed of seven judges who carried out semantic, cultural, and conceptual evaluations and made notes on the translation of the content. At this stage, the content validity showed excellent values for the Content Validity Index and modified Kappa, with 0.99 and 0.816, respectively. The tool was tested with 30 teachers and postgraduate students, where 90% of the respondents considered the tool to be sufficiently comprehensive and that all the items were relevant to the purpose of the instrument. In the last stage, the documents were analyzed together with the author of the original tool and the final version was approved. Conclusion: the Modelo de Planejamento de Tradução do Conhecimento results from a careful translation process, cross-cultural adaptation, and tool content validation. This has resulted in a tool that is applicable and understood by the target audience, which shows consistency in the equivalence of translation and cross-cultural adaptation for Brazil.

RESUMEN Objetivo: realizar la traducción, adaptación transcultural y validar el contenido de la Plantilla de Planificación para la Traducción del Conocimiento para el idioma portugués de Brasil. Método: estudio metodológico que siguió seis etapas: traducción inicial, síntesis de la traducción, retrotraducción, comité de expertos, pretest y aprobación de la versión adaptada por la autora de la herramienta. Em el comité de expertos, la validez del contenido se calculó mediante el índice de validez de contenido y el Kappa modificado. El pre-test se realizó con profesores y estudiantes de un programa de postgrado en la Universidad Federal de Santa Catarina. Resultados: el proceso de traducción y retrotraducción de la herramienta no mostró discrepancias en términos de significado. El comité estuvo formado por siete expertos que evaluaron los aspectos semánticos, culturales y conceptuales y realizaron observaciones sobre la traducción del contenido. En esta etapa, la validez de contenido mostró valores excelentes para el Índice de Validez de Contenido y el Kappa modificado, con 0,99 y 0,816 respectivamente. La herramienta se probó con 30 profesores y estudiantes de posgrado, donde el 90% de los encuestados consideraron que la herramienta era lo suficientemente completa y que todos los elementos eran pertinentes para el propósito de la herramienta. En la fase final, se analizaron los documentos junto con la autora de la herramienta original y se aprobó la versión final. Conclusión: el "Modelo de Planejamento de Tradução do Conhecimento" es el resultado de un proceso riguroso de traducción, adaptación transcultural y validación de contenido de la herramienta. El resultado fue una herramienta aplicable y comprensible para el público destinatario, y que muestra coherencia en la equivalencia de la traducción y la adaptación transcultural para Brasil.

RESUMO Objetivo: realizar a tradução, adaptação transcultural e validar o conteúdo da Knowledge Translation Planning Template para língua portuguesa do Brasil. Método: estudo metodológico, que seguiu seis etapas: tradução inicial, síntese da tradução, retrotradução, comitê de juízes, pré-teste e aprovação da versão adaptada pela autora da ferramenta. No comitê de juízes a validade do conteúdo foi calculada por meio do Índice de Validade de Conteúdo e Kappa modificado. O pré-teste foi realizado com docentes e discentes de um programa de pós-graduação da Universidade Federal de Santa Catarina. Resultados: o processo de tradução e retrotradução da ferramenta não apresentou discrepâncias em termos de significado. O comitê foi composto por sete juízes que realizaram avaliação semântica, cultural, conceitual e realizaram apontamentos quanto à tradução do conteúdo. Nesta etapa, a validade de conteúdo apresentou valores excelentes de Índice de Validade de Conteúdo e Kappa modificado, com 0,99 e 0,816 respectivamente. A ferramenta foi testada com 30 docentes e discentes de pós-graduação, onde 90% dos respondentes consideraram a ferramenta suficientemente abrangente, e que todos os itens são relevantes ao propósito da ferramenta. Na última etapa, os documentos foram analisados em conjunto com a autora da ferramenta original e a versão final foi aprovada. Conclusão: o Modelo de Planejamento de Tradução do Conhecimento é resultado de um processo criterioso de tradução, adaptação transcultural e validação de conteúdo da ferramenta. Isso gerou uma ferramenta aplicável e compreendida pelo público-alvo, a qual apresenta consistência na equivalência da tradução e adaptação transcultural para o Brasil.

Fatores associados à percepção do risco biológico e aos acidentes com material biológico em Agentes Comunitários de Saúde / Factors associated with the perception of biological risk and accidents with biological material in community health workers / Factores asociados a la percepción del riesgo biológico y de los accidentes con material biológico en los agentes comunitarios de salud

Objetivos: identificar fatores associados à acidentes com material biológico e à percepção do risco biológico entre Agentes Comunitários de Saúde (ACS). Métodos: estudo transversal analítico realizado com ACS, mediante aplicação de questionário e consulta de registros no cartão de vacinas. Regressão múltipla de Poisson com variância robusta foi realizada para analisar os fatores associados aos acidentes com material biológico e à percepção do risco biológico. Resultados: dos 207 participantes, 50,24% (IC 95% = 43,4 - 56,9) apresentou autorrelato de acidentes com material biológico, tendo como fatores associados possuir formação de nível superior [RP ajustada = 2,2 (IC 95% = 1,0 - 4,7)], ter outro vínculo empregatício [RP ajustada = 1,5 (IC 95% = 1,0 - 2,3)] e conhecimento quanto às vacinas necessárias ao ACS [RP ajustada = 0,7 (0,5 - 0,9)]. Constatou-se que 74,39% dos ACS tinham percepção de algum risco biológico, mesmo de forma limitada. Entre as variáveis investigadas, na análise ajustada, nenhuma mostrou associação com a percepção de risco biológico pelos ACS. Conclusão: a prevalência de acidentes com material biológico em ACS é elevada, sendo fatores associados possuir formação de nível superior, ter outro vínculo empregatício e apresentar conhecimento quanto as vacinas necessárias para a atividade laboral. Há limitada percepção de risco pela maioria dos ACS. Não foram encontrados fatores associados à esta variável.

Objectives: to identify factors associated with accidents involving biological material and the perception of biological risk among community health workers (CHWs). Methods: an analytical cross-sectional study was carried out with CHWs using a questionnaire and consultation of vaccination card records. Poisson multiple regression with robust variance was conducted to analyze the factors associated with accidents involving biological material and perception of biological risk. Results: of the 207 participants, 50.24% (95% CI = 43.4 - 56.9) self-reported accidents with biological material, and the associated factors were having a university degree [adjusted PR = 2.2 (95% CI = 1.0 - 4.7)], having another job [adjusted PR = 1.5 (95% CI = 1.0 - 2.3)] and knowledge of the vaccines needed by CHWs [adjusted PR = 0.7 (0.5 - 0.9)]. It was found that 74.39% of CHWs were aware of some biological risk, even to a limited extent. Among the variables investigated, in the adjusted analysis, none showed an association with the perception of biological risk by CHWs. Conclusion: the prevalence of accidents involving biological material among CHWs is high, and the associated factors are having a university degree, having another job, and having knowledge of the vaccines required for the job. Most CHWs have a limited perception of the risk. No factors were associated with this variable.

Objetivos: identificar los factores asociados a los accidentes con material biológico y la percepción del riesgo biológico entre agentes comunitarios de salud (ACS). Métodos: estudio transversal analítico realizado con los ACS mediante cuestionario y consulta de los registros de las cartillas de vacunación. Se realizó una regresión múltiple de Poisson con varianza robusta para analizar los factores asociados a los accidentes con material biológico y la percepción del riesgo biológico. Resultados: de los 207 participantes, el 50,24% (IC 95% = 43,4 - 56,9) declararon haber sufrido accidentes con material biológico, y los factores asociados fueron tener un título universitario [PR ajustado = 2,2 (IC 95% = 1,0 - 4,7)], tener otro trabajo [PR ajustado = 1,5 (IC 95% = 1,0 - 2,3)] y conocer las vacunas que necesitan los ACS [PR ajustado = 0,7 (0,5 - 0,9)]. Se observó que el 74,39% de los ACS conocían algún riesgo biológico, aunque fuera de forma limitada. De las variables investigadas en el análisis ajustado, ninguna mostró una asociación con la percepción del riesgo biológico por parte de los ACS. Conclusión: la prevalencia de accidentes con material biológico entre los ACS es alta, y los factores asociados son tener un título universitario, tener otro trabajo y tener conocimientos sobre las vacunas necesarias para el trabajo. La mayoría de los ACS tienen una percepción limitada del riesgo. No se encontraron factores asociados a esta variable.

El artículo científico: de la recepción del manuscrito a su publicación

El trabajo editorial casi nunca es visible en la cadena de la transmisión del conocimiento; sin embargo, es una tarea ardua, exhaustiva y precisa, en la evaluación, selección, producción y distribución del material científico, además de su difusión y marketing. Es por ello que en los siguientes párrafos se explicará, de manera sencilla, cómo es que el saber científico se construye, difunde y crea un nuevo saber, gracias a las editoriales y sus profesionales. Todo esfuerzo creador en el área de la ciencia debe tener constancia mediante un escrito, por ende, el objetivo del trabajo fue resumir el proceso de la creación del artículo científico desde la recepción del manuscrito hasta su publicación. Para ello se utilizó el método de la revisión narrativa. El artículo científico, como procedimiento individual o gremial para la difusión del desarrollo e innovación, ha sido el más empleado para mostrar el conocimiento novedoso, conservar el más antiguo y lograr que la información llegue a sus destinatarios, los cuales no necesariamente son generadores del saber humano, pero sí difusores. La descripción, evaluación y divulgación de la ciencia (socialización de la ciencia) ha sido un aspecto esencial en el desarrollo tecno-científico, que cuenta con medios certificados (revistas científicas) para acreditar y validar el conocimiento que se ha generado, o está en proceso, en un campo determinado, período de tiempo y región específicos.

Editorial work is almost never visible in the knowledge transmission chain; however, it is an arduous, exhaustive and precise task, in evaluating, selecting, producing and distributing scientific material, as well as its dissemination and marketing. That is why the following paragraphs will explain, in a simple way, how scientific knowledge is built, disseminated and creates new knowledge, thanks to publishers and their professionals. Every creative effort in the area of science must be recorded in writing, therefore, the objective of the work was to summarize the process of creating the scientific article since the reception of the manuscript to its publication; to this end, the narrative review method was used. The scientific article, as an separate or union procedure for the dissemination of development and innovation, has been the most used to show new knowledge, to preserve the first and to ensure that the information reaches its recipients, who are not necessarily generators of human knowledge, but diffusers. The description, evaluation and dissemination of science (socialization of science) has been an essential aspect in the techno-scientific development, which has certified means (scientific journals) to accredit and validate the knowledge that has been generated, or it is in progress, in a certain field, a given period and a specific region.

A infodemia COVID-19 à luz da teoria da complexidade de Edgar Morin: um estudo de reflexão

Objetivo: Refletir sobre a infodemia da COVID-19 sob a luz da Teoria da Complexidade de Edgar Morin e seus três principais principios, a saber o princípio dialógico, da recursão organizacional e hologramático. Metodologia: Trata-se de ensaio teórico de caráter reflexivo da literatura acerca da infodemia de COVID-19 sob a luz da Teoria da Complexidade de Edgar Morin. Resultados: Interrelacionando o princípio dialógico com a infodemia, pode-se refletir sobre a relação da ambivalência complexa entre a desinformação e informações validadas cientificamente e dos diversos conteúdos dissipados nos meios de comunicação. Ressalta-se que é necessário realizar uma síntese coerente e confiável sobre os conteúdos abordados e amplamente difundidos. A infodemia de COVID-19 submerge de uma intenção que ocorre nas entrelinhas dos meios de comunicação, e nessa intencionalidade há participação direta da sociedade. Compreende-se que a desinformação se amplia na medida em que a produção de conteúdo aumenta, nesse sentido, a desinformação produz a infodemia que, consequentemente, é produzida também pela desinformação. É possível refletir sobre a infodemia através da noção de que está pode influenciar e ser influenciada pelo todo, envolvendo assim, questões que atravessam a saúde pública, a economia, a política, ao mesmo tempo que é fomentada e influenciada por esses eixos específicos. Considerações finais: Os princípios do pensamento complexo, constituem-se como elementos que auxiliam a compreensão do fenômeno infodemia sua influência no contexto informacional. Espera-se que este estudo reflexivo possa contribuir para que sejam mitigadas as repercussões da infodemia no cotidiano dos usuários das redes de informação.

Objective: To reflect on the COVID-19 infodemic in the light of Edgar Morin's Complexity Theory and its three main principles, namely the dialogic principle, organizational and hologrammatic recursion. Methodology: This is a theoretical essay with a reflective character of the literature on the COVID-19 infodemic in the light of Edgar Morin's Complexity Theory. Result: Interrelating the dialogic principle with the infodemic, one can reflect on the relationship of the complex ambivalence between disinformation and scientifically validated information and the various contents dissipated in the media. It is noteworthy that it is necessary to carry out a coherent and reliable synthesis of the contents covered and widely disseminated. The COVID-19 infodemic is submerged in an intention that occurs between the lines of the media, and in this intention, there is direct participation by society. It is understood that disinformation increases as the production of content increases, in this sense, disinformation produces the infodemic which, consequently, is also produced by disinformation. It is possible to reflect on the infodemic through the notion that it can influence and be influenced by the whole, thus involving issues that cross public health, the economy, politics, at the same time that it is fostered and influenced by these specific axes. Final considerations: the principles of complex thinking are elements that help the understanding of the infodemic phenomenon and its influence in the informational context. It is hoped that this reflective study can contribute to mitigate the repercussions of the infodemic in the daily lives of users of information networks.

Objetivo: Reflexionar sobre la infodemia de la COVID-19 a la luz de la Teoría de la Complejidad de Edgar Morin y sus tres principios fundamentales, a saber, el principio dialógico, el organizativo y el hologramático de la recursividad. Metodología: Se trata de un ensayo teórico con carácter reflexivo de la literatura sobre la infodemia del COVID-19 a la luz de la Teoría de la Complejidad de Edgar Morin. Resultados: Interrelacionando el principio dialógico con la infodemia, se puede reflexionar sobre la relación de la compleja ambivalencia entre la desinformación y la información científicamente validada y los diversos contenidos disipados en los medios. Cabe destacar que es necesario realizar una síntesis coherente y confiable de los contenidos abordados y ampliamente difundidos. La infodemia del COVID-19 está sumergida en una intención que se da entre líneas mediáticas y en esa intención hay una participación directa de la sociedad. Se entiende que la desinformación se expande a medida que aumenta la producción de contenidos. En ese sentido, la desinformación produce la infodemia que, en consecuencia, también es producida por la desinformación. Es posible reflexionar sobre la infodemia a partir de la noción de que puede influir y ser influenciada por el conjunto, involucrando así cuestiones que cruzan la salud pública, la economía, la política, al tiempo que es fomentada e influenciada por estos ejes específicos. Consideraciones finales: Los principios del pensamiento complejo son elementos que ayudan a la comprensión del fenómeno infodémico y su influencia en el contexto informacional. Se espera que este estudio reflexivo pueda contribuir a mitigar las repercusiones de la infodemia en la cotidianidad de los usuarios de las redes de información.