ABSTRACT
Objective To study the preparation of temperature-sensitive hydrogel system,which is based on chitosan added by ?-glycerophosphate and is used to deliver the doxorubicin,and its delivery property.Methods The doxorubicin-containing temperature-sensitive hydrogel system based on chitosan was prepared;ultraviolet spectrophotometry was used to measure the content of doxorubicin;the drug release by the sustained release system was observed in vitro.Results Doxorubicin-containing temperature-sensitive hydrogel system based on chitosan was prepared and the release curve was obtained to express its delivery property.Conclusion The temperature-sensitive system based on chitosan can be used to deliver doxorubicin.The results provided the experimental basis for improvement of the delivery of doxorubicin.
ABSTRACT
Objective:To compare the survival rate and side effects of doxorubic in (ADM) liposome therapy and ADM therapy for liver cancer.Methods:87 patients with advanced liver cancer were divided into two groups:Group A was treated by ADM liposome chemotherapy and group B by ADM chemotherapy.Results:The mean survival and 1 year survival rates showed no obvious difference in both groups.However,patients in Group A showed better immediate curative effect and lower immediate side effects than Group B.Conclusion:ADM Liposome chemotherapy increase the immediate curative effects and decrease the general reactions.