Efficacy and safety of interventional therapy combined with drug injection under bronchoscope in the treatment of central non-small cell lung cancer / 中国临床药理学与治疗学

AIM: To evaluate the efficacy and safety of interventional therapy combined with tumor drug injection under bronchoscope for central non-small cell lung cancer (NSCLC). METHODS: Sixty-four patients who met the test admission criteria were randomly assigned to the experimental group and the control group according to the ratio of 1:1, and were given bronchoscopic interventional therapy combined with local drug injection of recombinant human endostatin combined with platinum-containing dual-drug chemotherapy and platinum-containing dual-drug alone, respectively. The curative efficiency and safety of the two groups were compared. RESULTS: Compared with the control group, the KPS score, dyspnea grading were significantly improved (P<0.05). The effective rate of the test group was 78.12%, which was higher than 37.5% in the control group, the difference between the two groups was significant (P<0.05). Moreover, there was also a significant difference in the 1-year survival rate between the experimental group and the control group (P<0.05). CONCLUSION: The treatment of central NSCLC by interventional therapy combined with tumor drug injection through fiberoptic bronchoscope has obvious clinical efficacy, which can effectively alleviate the clinical symptoms and improve the quality of life of patients. There is no significant difference in adverse reactions between the two groups, and is worthy of popularization and application.

Prevalence of HCV infection in a prison population of the greater Florianópolis area

Abstract INTRODUCTION The present study aimed to estimate the prevalence of Hepatitis C virus (HCV) infection in a prison population. METHODS: A total of 147 individuals were interviewed and subjected to venipuncture for collection of blood sample. The study population consisted of male individuals who attended the health unit of the state penitentiary of Florianópolis. RESULTS: The prevalence of HCV infection was 5.4%. Regarding behavioral variables, 95 (64.6%, p<0.0507) subjects reported consuming alcohol and 7 (4.8%, p<0.0476) reported having already used injectable drugs. CONCLUSIONS: The prevalence of HCV infection in the studied population was higher than that in the general populations.

The effect of drug injection under bronchoscopy on the retreatment of smear positive cavitary pulmonary tuberculosis / 实用医学杂志

Objective To explore the effect of drug injection under bronchoscopy on the retreatment of smear positive cavitary pulmonary tuberculosis. Methods From June 2016 to December 2017,164 cases of pul-monary tuberculosis with smear Yang cavity type were selected,which were divided into 2 groups according to the random digital table method,each groups has 82 cases.The control group received routine treatment,the observa-tion group underwent bronchoscopy with Kangfuxin Liquid combined with drug injection therapy.The clinical effect of the two groups,the changes of lung function before and after treatment and the improvement of clinical symp-toms were compared.Results The clinical curative effect of the treatment group was better than the control group, which difference was statistically significant(P < 0.05). FEV1,FEV1/FVC,PEF index in the observation group were better than the control group,which difference was statistically significant(P<0.05).The complication rate of observation group was lower than the control group,which difference was statistically significant(P < 0.05). Conclusion Drug injection under bronchoscopy can significantly improve the clinical efficacy and lung function and promote clinical symptoms in patients with retreated smear positive pulmonary tuberculosis.It is worthy of popu-larization and application.

Application of ViabahnTM serf-expanding covered stent in endovascular repair of femoral pseudoaneurysm caused by intravenous drug injection: report of nine cases / 介入放射学杂志

Objective To discuss the feasibility,safety and validity of ViabahnTM self-expanding covered stent in endovascular repair of femoral pseudoaneurysm caused by intravenous drug injection.Methods The clinical data of 9 patients with femoral pseudoaneurysm caused by intravenous drug injection,who were admitted to authors' hospital during the period from April 2014 to April 2015,were retrospectively analyzed.The pseudoaneurysms were located at the common femoral artery in 6 patients and at the superficial femoral artery in 3 patients.Endovascular repair with ViabahnTM self-expanding covered stent was performed in all the 9 patients.The intraoperative angiographic findings,the sizes of the implanted stents,and the manifestations of the angiography performed immediately after stent implantation were recorded,after operation,the patients were kept under close observation to evaluate the improvement of clinical symptoms,the effect of pseudoaneurysm repair,and the occurrence of endoleak,stent infection,in-stent stenosisand fracture of stent.Anti-infection treatment was employed both before and after the stent implantation;after the stent implantation debridement and/or drainage for soft tissue infection area of inguinal region was adopted.Results Successful implantation of ViabahnTM self-expanding covered stent was accomplished in all 9 patients,with a technical success rate of 100％.Angiography performed immediately after stent implantation showed that complete repair of pseudoaneurysm cavity was obtained in all 9 patients,the distal segment of the parent artery was patent,and no endoleak occurred.The patients were followed up for 6-12 months,and limb salvage was successful in all patients,no intermittent claudication or muscular atrophy occurred.CT angiographyreexamination showed that no endoleak,stent infection,stent fracture or in-stent stenosis occurred.Conclusion Under the conditions of adequate anti-infection,local debridement and drainage,the use of ViabahnTM self-expanding covered stent can promptly close the break of femoral pseudoaneurysm to save the patient's life.Because of the excellent qualities,such as flexibility,adhesion and patency,of ViabahnTM self-expanding covered stent,the postoperative occurrence of intermittent claudication,stent fracture and in-stent stenosis can be effectively reduced.It is expected that ViabahnTM self-expanding covered stent may become one of the vascular reconstruction methods for femoral pseudoaneurysm caused by intravenous drug injection,although its long-term curative effect needs to be further observed and verified.

Clinical observation on 63 cases of secretory otitis media treated by puncture combined with injection / 中国生化药物杂志

Objective To analyze the clinical effect of the treatment of secretory otitis media with puncture combined with injection.MethodsThe control group was given tympanic membrane puncture combined with conventional drug treatment, and the experimental group was given combined with tympanic tympanic membrane puncture injection and conventional medicine for treatment.ResultsThe total effective rate of the experimental group (95.2%) was significantly lower than that of the control group (66.7%)(P<0.05);The incidence of complications in the experimental group (6.3%) was significantly lower than that in the control group(22.2%)(P<0.05).ConclusionClinical efficacy and safety of the treatment of secretory otitis media with puncture and injection.

An analysis on the status of syphilis and HCV infection and influencing factors among community drug addicts in Jiaxing City / 预防医学

Objective To investigate the status of syphilis and HCV infection and the influencing factors among community drug addicts in Jiaxing City.Methods HCV and syphilis were detected among community drug addicts in Jiaxing City from 2014-2015 and a questionnaire survey were conducted.Influencing factors of syphilis and HCV was analyzed in this study.Results A total of 449 drug users including 356 males (79.29％) and 93 females (20.71％) were investigated,with the age ranged from 16 to 47 and averaged 27.50 ± 12.28.A total of 370 of them take addictive drugs (82.41％),including 42 of them take more than 2 kinds of drugs.15 cases of Syphihs (double positive) were found,and the positive rate was 3.34％.There were significant difference among community drug addicts with different education level (P ＜0.05).The positive rate of HCV among males were lower than that of females (P ＜ 0.05),and the positive rate of HCV among heroin addicts were higher than other drug addicts (P ＜ 0.05).The positive rate of HCV of injection drug users were higher than oral drug addicts(OR =17.341,95％ CI:8.387-35.857,P ＜ 0.01).There was associations among condom use with double positive syphilis and HCV (OR =0.210,95％ CI:0.064-0.689,P ＜0.01;OR =0.131,95％ CI:0.063 -0.273,P ＜ 0.01),respectively.Conclusion Community drug addics are mainly young adults,drug injection and not using condom may increase the risks of TP and HCV infection.

Endovascular treatment for ruptured femoral artery pseudoaneurysm associated with bleeding caused by injection of addictive drug / 介入放射学杂志

Objective To investigate the feasibility,safety and effectiveness of endovascular angioplasty with covered stent and embolization with spring coil in treating ruptured femoral artery pseudoaneurysm (FAP) associated with bleeding caused by injection of addictive drug.Methods The clinical data of 32 patients with ruptured FAP complicated by bleeding caused by injection of addictive drug,who were admitted to authors' hospital during the period from July 2012 to December 2015,were retrospectively analyzed.The average age of the patients was 36.5 years old,among them 25 patients were male (78.1％).Results Successful hemostasis was achieved in all 32 patients.The technical success rate of endovascular therapy was 100％,and no death occurred during perioperative period.Endovascular repair with covered stent was carried out in 25 patients (78.1％),embolization of femoral profound artery with spring coil in 9 patients (9.4％),and covered stent implantation together with embolization of femoral profound artery in 4 patients (12.5％).The patients were followed up for a mean of (17.5±11.6) months,with a follow-up rate being 93.8％ (30/32).The 3-year cumulative stent patency rate was 90.9％,and the 3-year overall survival rate was 91.3％.Conclusion For the treatment of ruptured FAP complicated by bleeding caused by injection of addictive drug,endovascular treatment is safe and effective with satisfactory mid-term clinical effect.This technique helps win the valuable time for critically ill patients to receive two-stage surgical debridement and vascular repair,as two-stage thorough debridement is an important means to control infection.

Comparison of bacterial contamination status of drug injection and nurses' work efficiency by using different ampoule products / 重庆医学

Objective To explore the effect of small package plastic ampoule products in preventing bacterial contamination of injectable drugs.Methods A retrospective study was carried out.In August 2015,78 first-line nurses in our hospital were recruited to the observation group using convenience sampling method,and the other 78 first-line nurses in the Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine were selected as the control group at the same period.The control group utilized glass ampoule products in intravenous infusion of drugs,while the observation group utilized plastic ampoule products.Recorded the incidence of bacterial contamination of injectable drugs and sharp instrument injury.Results The incidence rate of bacterial contamination of injectable drugs in the observation group (1.3 ％) was obviously lower than that in the control group (10.2 ％),there was statistically significant difference (P＜0.05).The times expended in opening and identifying ampoule products in the observation group were (20.42±3.22)s and (28.40-4-4.20)s,which were significantly shorter than times expended in the control group[(40.20±4.10)s and (34.20±t5.21)s],there were statistically significant differences (P＜0.05).No sharp instrument injury was observed in the observation group,and the incidence rate of sharp instrument injury in the control group was 5.1 ％,the incidence rate of the observation group was significantly lower than that of the control group (P＜0.05).Conclusion Clinical application of plastic ampoule products can shorten the nurses operating time,effectively prevent the bacterial contamination of injectable drugs,and reduce the occurrence of sharp instrument injury during operation.

Comparison of short-term and long-term efficacy of minimally invasive surgery and medication for early primary frozen shoulder / 中国内镜杂志

Objective To compare the short-term and long-term efficacy of minimally invasive surgery and medication for early primary frozen shoulder (PFS). Methods 82 patients with PFS from June 2014 to September 2015 were enrolled in the study and randomly divided into drug group and operation group, 41 cases in each. Patients in drug group were given steroid hormone intraarticular injection therapy while in operation group, patients were given arthroscopic clearance and release for glenohumeral joint and subacromial space. The baseline data, scores of visual analogue scale (VAS) and constant shoulder joint, active range of motion (ROM) of internal rotation, external rotation, abduction and flexion. Results There were no significant differences in baseline data, scores of VAS and constant shoulder joint, active range of motion (ROM) before treatment between the two groups (P > 0.05). Compared with them before treatment, the VAS scores of the two groups decreased significantly after treatment while constant shoulder score and active ROM increased significantly (P < 0.05). At 4 weeks after treatment, VAS scores in operation group was significantly higher than that in drug group, constant shoulder score and active ROM was significantly lower than that in drug group (P < 0.05). At 12 weeks, 6 months and 1 year after treatment, VASscore in the operation group was significantly lower than that in drug group, constant shoulder score and active ROM was significantly higher than that in drug group (P < 0.05). Conclusions Arthroscopic minimally invasive surgery and drug injection are all effective treatments for early PFS patients. The short-term efficacy of drug injection was significantly better, but the long-term effect was poor. Instead, the long-term effect of minimally invasive surgery was more prominent, and combined with oral drugs and postoperative rehabilitation could significantly improve shoulder joint function and the quality of life, which is worthy of promoting clinical application.

Comparison of bacterial contamination status of drug injection and nurses' work efficiency by using different ampoule products / 重庆医学

Objective To explore the effect of small package plastic ampoule products in preventing bacterial contamination of injectable drugs.Methods A retrospective study was carried out.In August 2015,78 first-line nurses in our hospital were recruited to the observation group using convenience sampling method,and the other 78 first-line nurses in the Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine were selected as the control group at the same period.The control group utilized glass ampoule products in intravenous infusion of drugs,while the observation group utilized plastic ampoule products.Recorded the incidence of bacterial contamination of injectable drugs and sharp instrument injury.Results The incidence rate of bacterial contamination of injectable drugs in the observation group (1.3 ％) was obviously lower than that in the control group (10.2 ％),there was statistically significant difference (P＜0.05).The times expended in opening and identifying ampoule products in the observation group were (20.42±3.22)s and (28.40-4-4.20)s,which were significantly shorter than times expended in the control group[(40.20±4.10)s and (34.20±t5.21)s],there were statistically significant differences (P＜0.05).No sharp instrument injury was observed in the observation group,and the incidence rate of sharp instrument injury in the control group was 5.1 ％,the incidence rate of the observation group was significantly lower than that of the control group (P＜0.05).Conclusion Clinical application of plastic ampoule products can shorten the nurses operating time,effectively prevent the bacterial contamination of injectable drugs,and reduce the occurrence of sharp instrument injury during operation.

Comparison of short-term and long-term efficacy of minimally invasive surgery and medication for early primary frozen shoulder / 中国内镜杂志

Objective To compare the short-term and long-term efficacy of minimally invasive surgery and medication for early primary frozen shoulder (PFS). Methods 82 patients with PFS from June 2014 to September 2015 were enrolled in the study and randomly divided into drug group and operation group, 41 cases in each. Patients in drug group were given steroid hormone intraarticular injection therapy while in operation group, patients were given arthroscopic clearance and release for glenohumeral joint and subacromial space. The baseline data, scores of visual analogue scale (VAS) and constant shoulder joint, active range of motion (ROM) of internal rotation, external rotation, abduction and flexion. Results There were no significant differences in baseline data, scores of VAS and constant shoulder joint, active range of motion (ROM) before treatment between the two groups (P > 0.05). Compared with them before treatment, the VAS scores of the two groups decreased significantly after treatment while constant shoulder score and active ROM increased significantly (P < 0.05). At 4 weeks after treatment, VAS scores in operation group was significantly higher than that in drug group, constant shoulder score and active ROM was significantly lower than that in drug group (P < 0.05). At 12 weeks, 6 months and 1 year after treatment, VASscore in the operation group was significantly lower than that in drug group, constant shoulder score and active ROM was significantly higher than that in drug group (P < 0.05). Conclusions Arthroscopic minimally invasive surgery and drug injection are all effective treatments for early PFS patients. The short-term efficacy of drug injection was significantly better, but the long-term effect was poor. Instead, the long-term effect of minimally invasive surgery was more prominent, and combined with oral drugs and postoperative rehabilitation could significantly improve shoulder joint function and the quality of life, which is worthy of promoting clinical application.

Progress of Endoscopic Treatment for Benign Esophageal Strictures / 中国微创外科杂志

[Summary] Benign esophageal strictures can arise from various causes and mainly induce dysphagia .Commonly , the majority of benign esophageal strictures can achieve long-term relief through about three dilation sessions .However, some refractory benign esophageal strictures require other treatments , such as endoscopic stent placement and intralesional drug injection , but these treatments just attain short-time satisfactory results with a disappointingly low rate of long-term improvement.Recently, biodegradable stents and drug-eluting stents are developing and have obtained the positive effects .In this paper , we performed a review about the treatment of benign esophageal strictures .

Effect of Drug Injection in Muscle Motor Points on Spastic Cerebral Palsy / 中国康复理论与实践

@#Objective To explore the effect of drug injection in muscle motor points on children with spastic cerebral palsy. Methods 230 children with spastic cerebral palsy were divided into control group and observation group, with 115 cases in each group. The control group received comprehensive rehabilitation including functional training, physical therapy and medicine, while the observation group received injection of vitamin B1 and vitamin B12 in muscle motor points in addition. They were assessed with Gross Motor Function Measure (GMFM), modified Ashworth Scale (MAS), mental development index (MDI) and psychomoter developmental index (PDI) of CDCC Infant Me Ntal Development Scale. Results The gross motor function improved, MAS score decreased, the scores of MDI and PDI increased after treatment (P<0.01) in both groups, which were better in the observation group than in the control group (P<0.05). Conclusion Drug injection in muscle motor points can improve the gross motor function, relieve spasm, and improve intelligence development of children with spastic cerebral palsy.

Effect of Drug Injection in Muscle Motor Points on Spastic Cerebral Palsy / 中国康复理论与实践

Objective To explore the effect of drug injection in muscle motor points on children with spastic cerebral palsy. Methods 230 children with spastic cerebral palsy were divided into control group and observation group, with 115 cases in each group. The control group received comprehensive rehabilitation including functional training, physical therapy and medicine, while the observation group re-ceived injection of vitamin B1 and vitamin B12 in muscle motor points in addition. They were assessed with Gross Motor Function Measure (GMFM), modified Ashworth Scale (MAS), mental development index (MDI) and psychomoter developmental index (PDI) of CDCC Infant Me Ntal Development Scale. Results The gross motor function improved, MAS score decreased, the scores of MDI and PDI increased after treatment (P<0.01) in both groups, which were better in the observation group than in the control group (P<0.05). Conclusion Drug injec-tion in muscle motor points can improve the gross motor function, relieve spasm, and improve intelligence development of children with spastic cerebral palsy.

Pain Control after Total Hip Replacement Arthroplasty Using Periarticular Multimodal Drug Injection

PURPOSE: This study attempted to evaluate the pattern of change of the pain after total hip arthroplasty (THA) and to confirm the effect of periarticular multimodal drug injection (PMDI) on controlling the early postoperative pain. MATERIALS AND METHODS: Of the total patients who underwent primary THA at our hospital because of osteonecrosis of the femoral head from March to October 2008, 60 patients were enrolled in this study. The subjects were divided into three groups. Groups 1 & 2 received periarticular injection. Group 1 included the patients who were injected with a combination of opioid, long-acting local anesthetics, a non-steroidal anti-inflammatory drug and epinephrine. Group 2 received a combination of morphine and ropivacaine and group 3 was not injected with any analgesics. The visual analogue scale (VAS) at 4 hours, 8 hours, 12 hours, 24 hours, 2 days, 3 days, 5 days, 14 days and 1 month after surgery, the frequency that patients pushed the self-controlled pain medication machine for 2 days after surgery and the amount of clonac that was injected according to the needs of the patients were used as objective measures. RESULTS: The VAS score at postoperative 4 hours to 3 days among the groups showed a significant difference (P0.05). The frequency of pushing the self-controlled pain medication machine among the groups and the amount of clonac according to the needs of the patients among the groups showed that there were significant decreases at the operation day, the postoperative 1, 2 day and the 3 days (P<0.05). CONCLUSION: PMDI has a significant effect on controlling the early postoperative pain after THA.

Randomized Clinical Trial of Periarticular Drug Injection used in combination Patient-Controlled Analgesia versus Patient-Controlled Analgesia Alone in Total Knee Arthroplasty

This is a prospective randomized clinical trial to compare use of a combination of periarticular drug injection with patientcontrolled analgesia (PCA) to PCA alone in post-total knee arthroplasty (TKA). Thirty patients who were admitted for unilateral total knee arthroplasty were selected randomly into an Injection group or a Standard group. The periarticular injection contained Ropivacaine, Ketorolac and Adrenaline, given intra-operatively. The mean amount of opioid used was 22.87 mmol/L in the Injection group as compared to 39.78 mmol/L in the Standard group (p = 0.026). The Injection group had lower pain score at rest and during exercise (p=0.021, p=0.041, respectively), as well as better return to function (p=0.026) and shorter hospital stay (6.1 days, Injection; 7.5 days, Standard, p=0.027). Overall, the group receiving periarticular drugs injection had less pain, less narcotic usage, earlier return to function, similar experience of adverse effects and shorter hospital stays.

Local drug injections for analgesia after total knee arthroplasty / 中国矫形外科杂志

0.05).[Conclusion]Periarticular drug injection during TKA and intra-articular drug injection after operation can relieve pain early after TKA,improve the range of motion of the knee and rehabilitation,no further side effect has been noted.

The Influence of Blood Pressure of Patients Undergoing Cesarean Section with Combined Spinal-Epidural Anesthesia / 医学研究杂志

Objective To investigate the influence of Bupivacaine injection speed on blood pressure of patients undergoing cesarean section.Methods 90 patients(ASAⅠ-Ⅱ)who underwent cesarean section were selected with combined spinal-epidural anesthesia were divided randomly into three groups(20 for each).0.5% bupivacaine 1.4ml(7mg),the speed of injection in group A,group B and group C is 10 seconds,20 seconds,30 seconds.Systolic blood pressure(SBP),Diastolic blood pressure(DBP)and Heart rate(HR)were recorded before anesthesia and 5min,10min,15min and 30min after anesthesia.Cases need to be added epidural drug were all recorded.Results The age,body length and body weight in the three groups has no significant difference,location of injection and posture were same.The best effect of anesthesia was founded in group B,blood pressure(BP)and HR was stable.The effect of anesthesia was better but BP and HR were obviously descent in group A.The block level of anesthesia was unsatisfactory and need to add epidural drug in group C.Conclusion The injection speed of 0.5% bupivacaine 1.4ml in combined spinal-epidural anesthesia is suitable of 20 seconds when patients underwent cesarean section.

Observation of injection drug speed in ropivcaine combined spinal epidural anesthesia / 中国基层医药

Objective To investigate the effect of ropiyacaine combined with intra-spinal epidural anesthesia by using the same volume but different injection speed on anaesthetic level.Methods 80 cases of patients of ASA～Ⅱdegree suitable to use intra-spinal epidural combined anesthesia for gynecologic operation were selected and ran- domly divided into three groups,0.75 % ropivacaine 2mg(15mg)administered,group A the speed of injection was 10 seconds,group B injection speed was 20 seconds,group C injection speed was 30 seconds,the anaesthetic level reached T_(10).The time of highest level in spinal anesthesia,30 minutes after spinal anesthesia MAP,and number of cases need to add epidural drug were all recorded.Results The best effect of anesthesia was found in group B,the block level of anesthesia was satisfactory,blood dynamic was stable,and there was no need to add epidural drug.Conclusion The speed of 0.75 % ropivacaine 2ml spinal epidural combined with anesthesia was suitable at the speed of 20 seconds.

Arm necrosis due to intra-arterial drug injection: report a case

Injection-related necrosis is a common pattern in the arterial injuries. But the acute embolization that led to extremity necrosis is very rare. Here we described a case of 43-year male patient with arm necrosis due to intra-arterial drug injection. The patient has addicted drug for 24 years and has injected opium for 18 years with dose of 2 ml self-prepared opium solution, 3-4 times daily. On April 2000, after second injection of a day, the patient felt burn and pain in his left hand. Then watery purples and necrotic papules appeared on the skin of left arm. He was treated by antibiotics, analgesics, and vasodilators, but the condition was not improved. The patients had to be amputated his left arm after 3 days of admission.