ABSTRACT
Phospholipids are the major components of the biomembrane. Combining the phospholipids and the drugs to form drug-phospholipid complex can improve the solubility, stability and bioavailability of the drugs. On this basis, the nanodrug delivery system, which is constructed with the drug- phospholipid complex as an intermediate carrier, has become a research hot spot in the field of pharmaceutics. This kind of nanodrug delivery system can not only improve the solubility, stability and bioavailability of drugs, but also carry out the targeted drug delivery, decrease the drug dose and reduce the side effects, thereby it is very promising. In this review, we describe the structural composition, characteristics, forming mechanism of the drug-phospholipid complex and the research progresses in a variety of nanodrug delivery systems based on drug-phospholipid complex.
ABSTRACT
Phospholipids are the major components of the biomembrane. Combining the phospholipids and the drugs to form drug-phospholipid complex can improve the solubility,stability and bioavailability of the drugs. On this basis,the nanodrug delivery system,which is constructed with the drug-phospholipid complex as an intermediate carrier,has become a research hot spot in the field of pharmaceutics. This kind of nanodrug delivery system can not only improve the solubility,stability and bioavailability of drugs,but also carry out the targeted drug delivery,decrease the drug dose and reduce the side effects,thereby it is very promising. In this review,we describe the structural composition,characteristics,forming mechanism of the drug-phospholipid complex and the research progresses in a variety of nanodrug delivery systems based on drug-phospholipid complex.