ABSTRACT
Dystrophic calcinosis cutis associated with spontaneous hyperadrenocorticism was diagnosed in a 8-year-old female Chihuahua dog with erythematous, erosive, numerous papules, plaques, and crusts on the bilateral trunk, and inguinal region. Serum biochemical abnormalities included increases in alkaline phosphatase (ALP), alanine aminotransferase (ALT), gamma-glutamyl transpeptidase (GGT), and cholesterol. Radiographs showed mild hepatomegaly and subcutaneous lobulated calcific deposits. Histopathologic examination demonstrated diffuse deposition of basophilic calcified material in the dermis. Von Kossa's stain confirmed calcium deposition. Therapy with diltiazem was useful in resolving calcinosis.
Subject(s)
Animals , Child , Dogs , Female , Humans , Adrenocortical Hyperfunction , Alanine Transaminase , Alkaline Phosphatase , Basophils , Calcinosis , Calcium , Cholesterol , Dermis , Diltiazem , gamma-Glutamyltransferase , HepatomegalyABSTRACT
Localized scleroderma is a connective tissue disorder characterized by thickening and fibrosis of the skin due to excessive collagen deposition in the dermis. Dystrophic calcinosis occurs when calcium is deposited in the previously damaged skin tissue, and calcium and phosphorous levels in the blood are within normal limits. It occurs secondary to connective tissue disease, infection, inflammatory processes, chronic venous stasis, cutaneous neoplasm, and trauma. We report a rare case of dystrophic calcinosis cutis with transepidermal elimination secondary to localized scleroderma.
Subject(s)
Calcinosis , Calcium , Collagen , Connective Tissue , Connective Tissue Diseases , Dermis , Fibrosis , Scleroderma, Localized , SkinABSTRACT
Localized scleroderma is a connective tissue disorder that's characterized by thickening and fibrosis of the skin due to excessive collagen deposition. Localized scleroderma differs from systemic sclerosis according to the absence of Raynaud's phenomenon, sclerodactyly or systemic involvement. Dystrophic calcinosis cutis occurs in up to 10% of the patients with systemic sclerosis, but it is rare in localized scleroderma. Only seven cases of localized scleroderma with calcinosis cutis have been reported in the English medical literature. We report here on a 57-year-old woman with localized scleroderma with dystrophic calcification, and this was identified by the histopathology and CT scans. The serologic tests for the autoimmune antibodies anti-RNP, ENA and anti-SS-A(Ro) were all positive.
Subject(s)
Female , Humans , Middle Aged , Antibodies , Calcinosis , Collagen , Connective Tissue , Fibrosis , Scleroderma, Localized , Scleroderma, Systemic , Serologic Tests , SkinABSTRACT
Dystrophic calcinosis cutis is diagnosed, when calcium is deposited in the previously damaged tissue by connective tissue disease, panniculitis, pseudoxanthoma elasticum or trauma. We report a case of dystrophic calcinosis cutis arising from the lesion of clear cell syringoma. A 73-year-old woman presented with asymptomatic, multiple, skin-colored to whitish flat papules on the forehead. A punch biopsy specimen revealed amorphous basophilic materials in the upper dermis, as well as a large number of nests of clear cells in the middle dermis.
Subject(s)
Aged , Female , Humans , Basophils , Biopsy , Calcinosis , Calcium , Connective Tissue Diseases , Dermis , Forehead , Panniculitis , Pseudoxanthoma Elasticum , SyringomaABSTRACT
Calcinosis cutis is the deposition of insoluble calcium salts in the skin. Dystrophic calcinosis cutis is diagnosed when calcium is deposited in the previous damaged tissue and the values of calcium and phosphorus levels are normal. We report a case of dystrophic calcinosis cutis in a 32-year-old man. He had experienced a burn accidentally on the left anterior thigh at 2 years old. About 1 year ago, an ulcer developed on the burn scar. He found the chalky material in an ulcer and removed it, then the ulcer healed. But, new ulcers developed in a linear pattern. Histopathologically, amorphous eosinophilic materials that were black with Von Kossa stain were deposited in the dermis.
Subject(s)
Adult , Child, Preschool , Humans , Burns , Calcinosis , Calcium , Cicatrix , Dermis , Eosinophils , Phosphorus , Salts , Skin , Thigh , UlcerABSTRACT
Calcinosis cutis is the deposition of calcium phosphate into the skin. It is classified as dystrophic if the calcium is deposited in previously damaged tissue and serum calcium and phosphorous levels are normal. We report a case of dystrophic calcinosis cutis in a 35-year-old man. About 2 months ago, he developed an ulcer in the left thigh that was treated by grafting. Histopathologically, amorphous basophilic materials that stained with von Kossa were deposited in the dermis.