A study on sentinel lymph node biopsy in early breast carcinoma and its outcome on management

Background: Breast cancer is a major health problem and was among the top three most common malignancies in the world. It is the most common cancer in women. It ranks fifth among the most common causes of cancer-related death worldwide, while it is the most frequent cause of cancerrelated mortality in less developed countries. The aim of the study: The status of the lymph nodes in the axis is one of the key factors in patients with breast cancer. Histological examination of lymph nodes is the most accurate method for assessing lymph node metastasis. Materials and methods: A prospective study conducted on 20 patients in Government Royapettah Hospital in 2018. Early breast carcinoma with clinically axillary node negative and they was all undergoing sentinel lymph node biopsy and evaluated the outcome of the report with the postoperative histopathological report. Results: 12 cases were positive for sentinel lymph node biopsy and the postoperative report concluded the same. 8 cases were negative and hence proceeded with breast conservative surgery. Since only about 1/3rd of patients with clinically negative axilla had nodal metastases after postoperative histopathological examination of the ALND specimen, a significant number of patients would be at risk for the morbidity of ALND without benefiting from the procedure. Conclusion: Thus Sentinel lymph node biopsy alleviates the unnecessary need of axillary lymph node dissection in clinically node-negative patients.

A Clinical Study of Subcutaneous Mastectomy with Immediate Reconstruction as Treatment for Early Breast Carcinoma

Immediate breast reconstruction following subcutaneous mastectomy for early breast carcinoma remains controversial. According to the recent reports however, it has become a recommendable option for the care of breast cancer patients whether it involves prosthetic implantation or myocutaneous flap procedure. Many technical problems have been introduced to reconstruct the breast; choice of incision, volume estimation, mobility of skin flap including nipple-areolar complex, irregularity of flap thickness, location of inframammary fold and choice of implant type. We have experienced 43 cases of immediate breast reconstruction by using tissue expander, breast implant and transverse rectus abdominis musculocutaneous(TRAM) flap after subcutaneous mastectomy. We believe that immediate breast reconstruction with autogenous tissue is very satisfactory in aesthetic, economic aspects, whereas reconstruction with prosthetic implantation is a convenient method but prone to unsatisfactory long-term results.

Histologic detection of non-sentinel lymph node of early breast cancer patients with positive sentinel lymph node and its clinical significance / 中国癌症杂志

Purpose:To explore the possibility of non-sent inel lymph node (NSN) metastases in early breast carcinoma patients with positi ve sentinel lymph node (SLN) and its clinical significance. Methods:The incidence and related clinical factors of NSN metas tases were analyzed in 84 early breast carcinoma patients with positive sentinel lymph node, who underwent radical mastectomy. Results:The metastatic NSN was identified in 41 of the 84 pati ents with positive sentinel lymph node (48.8%), the incidence of NSN metastases was related to primary tumor size, SLN metastatic focus size and HER-2 expressi on status, the incidence rate of NSN metastases is proportional to the size of t he primary tumor and metastatic SLN focus, patients with positive HER-2 expres sion have a high NSN metastases rate. Conclusions:The early breast carcinoma patients with