ABSTRACT
Objective To investigate the effect of high fluxes of hemodialysis combined with Niaoduqing granuleson in the cell-mediated immunity of elderly hemodialysis patients. Methods Fourty cases of elderly main-tenance hemodialysis patients with end-stage renal disease were randomly divided into control group and treatment group,low flux dialysis was used in both groups before the experiment,in the experiment control group adopts high flux hemodialysis,the treatment group in the control group on the basis of daily oral Niaoduqing granules 5 g, 3 times/d,observation for 3 months,compare the serum IL-2,IL-10,CD3+,CD4+,CD8+,CD4+/CD8+change of the two groups in 3 months.Results After 3 months high flux dialysis treatment,the level of IL-2 was significant-ly increased before the treatment of low flux dialysis,and the level of IL-10 was significantly reduced.The levels of IL-2 and IL-10 were significantly higher in the treatment group than in the control group after 3 months(P <0.01);The CD3+,CD4+and CD4+/CD8+levels of the two groups of high flux dialysis were significantly higher than that in the previous three months(P<0.05).The levels of IL-2,IL-10,CD3+,CD4+,CD4+/CD8+were significantly higher in the treatment group after 3 months than the control group(P<0.05).Conclusion High fluxes of hemo-dialysis can improve the immune function of elderly hemodialysis patients,while combined with Niaoduqing gran-ules is more obvious.
ABSTRACT
The purpose of this study was to evaluate the nutritional status and to identify related factors in elderly hemodialysis patients. Sixty-four patients who were registered in Asan Medical Center, Seoul, Korea, participated in the study. The data was collected between September and December, 2003. General characteristics were obtained with the use of an interviewer-administered questionnaire. Anthropometric and biochemical data, 3-day dietary records and dietary habits were also obtained. The results of this study were analyzed with t-test or x2-test using SPSS package program. The percentage of elderly hemodialysis patients who were undergoing mild to severe malnutrition (MN group)and were normal nutrition (NN group) by subjective global assessment (SGA) criteria were 46.9% and 53.1%, respectively. Appetite (p<0.05) and dietary cholesterol intakes (p<0.05) were significantly lower in MN group than the NN group. Body mass index (BMI, p<0.001), lean body mass (LBM, p<0.05), triceps skinfold thickness (TSF, p<0.01), mid arm circumference (MAC, p<0.01)and mid arm muscle circumference (MAMC, p<0.05) were also lower in the MN group than the NN group. There were also significant differences in blood urea nitrogen (BUN, p<0.05), creatinine (p<0.05) , prealbumin (p<0.001) and C-reactive protein (CRP, p<0.05) . SGA was negatively correlated with serum BUN, creatinine and prealbumin, dry weight, BMI, LBM, total body water, TSF, MAC and MAMC, and positively correlated with age. In stepwise multiple regression analysis, SGA was related to BMI, CRP, age and BUN. In conclusion, almost half of the subjects were in malnourished status and had lower values in anthropometric and biochemical data. Our results suggest that SGA is a simple and adequate method for assessing the nutritional status in elderly hemodialysis patients and adequate dietary guidelines based on individual nutritional status are needed in the patients.