ABSTRACT
Objective To study the endothelium-dependent d il atative function (EDDF) in the patients with diabetes mellitus (DM) and essentia l hypertension (EH). Methods A total of 25 DM patients and 25 EH were chosen as the experimental group and 20 matched normals were chosen a s the control group. EDDF was assessed with B-mode ultrasonography for the chan ges in the diameter of the brachial artery during reactive hyperemia and after t aking in nitroglycerin. Results The changes of brachial art ery diameter during reactive hyperemia were slighter in DM and EH patients. The changes of branchial artery diameter after sublingual glyceryl trinitrate were s lighter in DM patients. Conclusion Endothelial dysfunction exist in the patients with DM; and endothelium-dependent vasodilatative dysfunc tion exist in the patients with EH.