Clinical Features,Diagnosis and Treatment Methods of Eosinophilic Granuloma of Bone in Children / 实用儿科临床杂志

Objective To study the clinical features,diagnosis and treatment of eosinophilic granuloma of bone(EGB).Methods Twelve cases(8 male and 4 female)of EGB and their medical record,imaging examinations,follow-up data were reviewed,and the lesion sites,symptom and clinical features were analyzed with reference to relative literature.Results Nine unifocal cases were found in the cervical spine(3 cases),the thoracic spine(1 case),the lumber spine(1 case),the femur(1 case),the metacarpal bones(1 case),and the ilium(2 cases).Three multifocal cases were found in the thoracic and lumber spine(1 case),in the femur,the multiple ribs,the skull,the scapula(1 case)and in the skull,the femur,the ilium(1 case).The most common presenting symptom was pain at the lesion site and restricted motion was obviously in the cervical lesion.The case of the thoracic lesions was found neurologic deficit.Osteolytic destruction was found in the radiologic examination in EGB and the periosteal reaction was found in the long bone lesions,and vertebra plana was considered as typical cha-racteristics in the spine lesion.The lesions not in the spine were diagnosed by biopsy,exclusive methods and close following-up were performed in the spine lesions.Two unifocal were healed spontaneously and three were performed with curettage with one bone grafting.Multifocal and the lesions in the spine underwent chemotherapy.All cases were followed up and no recurrence was found.Conclusions EGB is commonly solitary and not seldom in the spine.Topical pain may be chief complaint.Osteolytic image was found in the radiologic examination.Biopsy and exclusive methods combining closely follow-up were used for diagnosis.EGB is self-limited observation,so curettage or chemotherapy can be used in treatment,and prognosis is good.

The Evaluation of the Diagnosing Eosinophilic Granuloma of Bone with CT and X-ray Plain Film / 实用放射学杂志

Objective To discuss the diagnostic value of bone esoinophilic granuloma with CT and X-ray plain film.Methods The X-ray and CT manifestations of 39 patients with esoinophilic granuloma of bone confirmed by pathology were analysed retrospectively.Results Monofocal lesion was found in 22 cases(56.4%) and multifocal lesions were in 17 cases(43.6%).Monofocal lesion was most seen in skull 8 cases in this group(36.4%).The X-ray and CT manifestations of bone eosinophilic granuloma were varied with the site and pathologic process of lesion.Conclusion CT is better than plain film in demonstrating the internal components of bone eosinophilic granuloma,especially the button sequestrum and soft tissue mass in the lesion,but plain film examination still can't be replaced with CT scan.Plain film is still the primary method in diagnosis of eosinophilic granuloma of bone.

Eosinophilic Granuloma of Bone / 대한정형외과학회잡지

Eosinophilic granuloma of bone, characteristically a disease of children and young adults, is the most benign variant of histiocytosis X. This benign bone destructive lesion is characterized by the presence of a histiocytic and eosinophilic leukocyte infiltrate of unknown origin. It was described as a new distinct entity by Jaffe and Lichtenstein(1940). we reviewed the ll patients with eosinophilic grnuloma of bone from January 1980 to December 1985. The average length of follow-up was 20 months, with a range of 10 to 38 months. The results were as follows. l. Incidence was 2.24% of primary bone tumor. 2. Male patient was more predominent. 3. Age of onset was between 2 and 16 years old. 4. Predilection sites were spine, skull, pelvis and femur in order. 5. Solitary lesion was more comon(63.5%). 6. Onset of multiple lesions was earlier age. 7. There was on recurrence of lesions.