ABSTRACT
Introduction: Punica granatum is known to have long history of medicinal use. Aqueous fractions prepared from pomegranate peel extract has been found to stimulate type 1 procollagen synthesis and inhibit matrix metalloproteinase (which breaks down skin protein) produced by dermal fibroblasts. Objectives: To study the effect of a topical Punica granatum peel extract on healing of burn wound and to compare its effect with that of standard (silver sulfadiazine). Materials and Methods: Partial thickness burn wounds were inflicted upon wistar rats by pouring hot molten wax at 80˚C in to a metal cylinder with 300mm square circular opening, placed on the back of the animal. There were four groups in the study viz. control (topical petroleum jelly), standard (topical Silver Sulphadiazine Cream) and test groups (topical Punica granatum peel extract 10% and 20 %). The parameters measured were wound contraction and epithelization period in this burn wound model. Results & Discussion: The percentage of wound contraction was significantly increased in the topical Punica granatum extract (10% and 20%) and silver sulfadiazine group compared to control group. The mean period of epithelization was significantly reduced in topical Punica granatum extract (10% and 20%) group and silver sulfadiazine group as compared to the control. Conclusion: Punica granatum peel extract is effective in healing burn wound and the effect was comparable to the standard drug silver sulfadiazine.
ABSTRACT
The dexamethasone suppressed and normal wound healing effect of ethanolic extract of leaves of Hyptis suaveolens (L) poit. (EEHS) at 400mg/kg and 800mg/kg was studied in Wistar rats. Two wound models viz. incision and excision wounds were used in this study. The parameters studied were breaking strength in case of incision wounds, period of epithelization and wound contraction in case of excision wound. The dexamethasone treated group showed a significant (P<0.05) reduction in the wound breaking strength in incision type of wound model and significant increase in epithelization period and reduction in percentage of wound contraction in excision type of wound model as compared to control group. Extract treated groups showed significant (P<0.05) improvement in all the wound healing parameters of incision and excision wound models as compared to control. In incision wound model, Co administration of EEHS at both the dosage levels with dexamethasone had significantly (P<0.05) increased the wound breaking strength as compared to dexamethasone only treated group and was seen more at dosage level of 400mg/kg. Similarly, in excision wound model, there was significant improvement (P<0.05) in both the parameters when EEHS was co administered with dexamethasone as compared to dexamethasone only treated group but improvement was more at dosage level of 800mg/kg.