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Objective To study the feasibility of novelty detection model in assessing the subject novelty of medical literature and comparatively analyze the advantages and disadvantages of words-overlap algorithm and co-words-based inverse file frequency quantitative algorithm. Methods Two novelty detection models were established for the 8 research subjects in PubMed-covered literature. The feasibility of two novelty detection models in assessing the subject novelty of medical literature was assessed according to the subject novelty of literature analyzed by experts, ROC curves and AUC values. Results Words-overlap algorithm showed that the fluctuating amplitude of subject novelty was rather high, which can thus reflect the difference between the contents in literature on the data. ROC curves and AUC values-based analysis revealed a high accuracy of words-overlap algorithm for judging the novelty of literature while co-words-based inverse file frequency quantitative algorithm displayed a low accuracy for judging the novelty of literature. Conclusion The novelty of literature detected with the two novelty detection methods is moderately related. The mean novelty value detected with the two novelty detection methods is of statistical signifi-cance. However, the novelty of literature detected with words-overlap algorithm is higher than that detected with co-words-based inverse file frequency quantitative algorithm.
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Since the invention of optogenetic technology, it has greatly promoted the development of neuroscience. Currently, optogenetic approaches have been mostly used to map neural circuits and new neuropharmacology but are rarely seen in the research field of acupuncture analgesia. The mechanism of neural circuits contributing to acupuncture analgesia, an important research hotspot in recent years, has not been fully determined. The optogenetic techniques can be used to modulate and control specific cells, provides highly precise spatial and temporal resolution, is repeatable, and may functionally dissect neuronal networks in vivo. The neuronal activities and their information transmission, processing and storage in intercluster neural networks in different brain regions, and the correlation between behavioral changes and electrical activities of neurons in vivo studies are mainly captured by the implanted microelectropode array, etc. If these two (or more) approaches are combined together, it is definitely and highly helpful to reveal the driving dynamics of neural circuits, plasticity and temporal-spatial activity mode of neurons, as well as behavioral reactions of animals with chronic pain during acupuncture analgesia and may open a new prospect for the application of acupuncture analgesia study.
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Objective To investigate the feasibility of CT-guided radiofrequency ablation for conservative treatment of patients with large hepatocellular carcinoma (LHCC) before radical resection. Methods Patients with secondary large liver cancer were selected as group A(radiofrequency ablation group,n = 27)and group B (surgical treatment group ,n = 33). Liver function ,immunological function ,postoperative complications ,hospi-talization time ,and 3-year relapse-free survival (RFS) were observed between two groups after treatment. Results After treatment,patients′liver function(ALT,AST,ALB,TB),and immune function(CD3+T,CD4+T, CD8+T,CD4+/CD8+,NK,B,Treg)in group A were better than those in group B(P<0.05). There were shorter hospitalization time and lower complication rate in group A when compared with those in group B(P < 0.05)but there was no significant difference regarding to 3-year RFS(P > 0.05). Conclusions Although radiofrequency ablation cannot effectively improve patients′ RFS,but with faster postoperative recovery,less complications,and effective protection for liver function and immune function of patients ,it is a feasible conservative treatment for patients′with LHCC before radical resection.
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Objective To investigate the feasibility of CT-guided radiofrequency ablation for conservative treatment of patients with large hepatocellular carcinoma (LHCC) before radical resection. Methods Patients with secondary large liver cancer were selected as group A(radiofrequency ablation group,n = 27)and group B (surgical treatment group ,n = 33). Liver function ,immunological function ,postoperative complications ,hospi-talization time ,and 3-year relapse-free survival (RFS) were observed between two groups after treatment. Results After treatment,patients′liver function(ALT,AST,ALB,TB),and immune function(CD3+T,CD4+T, CD8+T,CD4+/CD8+,NK,B,Treg)in group A were better than those in group B(P<0.05). There were shorter hospitalization time and lower complication rate in group A when compared with those in group B(P < 0.05)but there was no significant difference regarding to 3-year RFS(P > 0.05). Conclusions Although radiofrequency ablation cannot effectively improve patients′ RFS,but with faster postoperative recovery,less complications,and effective protection for liver function and immune function of patients ,it is a feasible conservative treatment for patients′with LHCC before radical resection.
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Objective To analyse the breast conserving surgery feasibility in patients with advanced breast cancer after neoadjuvant chemotherapy.Methods Sixty patients with advanced breast cancer were collect-ed from June 2010 to June 2011, and were divided into breast conserving surgery after neoadjuvant chemotherapy group and modified radical mastectomy group according to the intention,30 cases in each group.They were given breast conserving surgery after neoadjuvant chemotherapy and modified radical mastectomy respectively,with fol-lowing-up for 3 years.The treatment effect and contrast analysis of two groups of breast cancer CTCs positive of the two groups were compared,two groups of late follow-up of patients with local recurrence and distant metasta-sis rate,overall survival and disease free survival rate were recorded.Results Compared with the modified radi-cal mastectomy group,CTCs detection rate in breast conserving surgery group had no statistical differences(P>0.05).Two groups of patients in clinical complete remission rate,partial remission rate,disease stability factor and local recurrence and distant metastasis rate,overall survival and disease free survival rate had no statistical significances(P>0.05).Conclusion The application of breast conserving surgery after neoadjuvant chemother-apy for patients with advanced breast cancer can achieve similar effect as modified radical mastectomy surgery treatment,and can be used as a effective treatment for advanced breast cancer.