Prognosis and related factors of different treatments for patients with gastric stump cancer / 局解手术学杂志

Objective To evaluate the efficacy of different surgical treatments for 60 cases of gastric stump cancer patients and their prognostic factors. Methods Retrospectively analyze the clinical data of 60 cases of gastric stump cancer patients,and divided them into rad-ical surgery group (38 cases) and non-radical surgery group (22 cases) in accordance with the surgical methods. Survival rate and prognostic factors of 1,3 and 5 years after operation were compared. Results As of May 2007,a total of 7 patients of radical surgery group survived. Survival rate of 1,3 and 5 years after operation were respectively 89. 5%,44. 7%,and 18. 4% in the radical surgery group while 40. 9%, 1. 0%,0. 0% in the non-radical surgery group. Median survival time was 22 months in the radical surgery group and 14 months in the non-radical surgery group. The survival rate of the two groups were of a significant difference (P<0. 05). Conclusion Survival rate,TNM stage, radical surgery,degree of differentiation,lymph node metastasis,peritoneal metastasis,and liver metastasis are all independent prognostic fac-tors which affect gastric stump cancer.

Clinical features analysis of 272 patients with gastric stump ulcer / 中华消化杂志

Objective To investigate the clinical features of gastric stump ulcer (GSU)after partial gastrectomy due to gastroduodenal ulcer.Methods From January 1st 2007 to October 31th 2013,272 patients with partial gastrectomy for gastroduodenal ulcer underwent gastroscopy due to upper gastrointestinal symptoms were collected.Among them,there were 237 male patients and 35 female patients with the average age (55 .4 ± 13.0 )years.The lesion location,symptoms and pathological changes of GSU were analyzed.Chi-square test and Fisher exact probability analysis were used for count data comparison.The t test was performed for measurement data comparison.Results There was no significant difference between patients with GSU after Billroth Ⅰ gastrectomy and Billroth Ⅱ gastrectomy in the incidence of dysphagia,nausea and vomiting,retrosternal pain,retrosternal buring sensation,upper abdominal pain, abdominal distention, acid regurgitation and (or) epigastric buring sensation, hematemesis and (or)melena (all P >0.05 ).The proportion of ulcer located in remnant stomach and anastomotic stoma of patients with Billroth Ⅰ gastrectomy (24.7%,18/73 and 72.6%,53/73 )was higher than those of patients with Billroth Ⅱ gastrectomy (10.1 %,20/199 and 58.3%,116/199 )and the difference was statistically significant (OR=2.929 and 1 .896,95 %CI :1 .448 to 5 .927 and 1 .055 to 3.409,χ2 =9.482 and 4.649,P =0.002 and 0.031 ).There was no significant difference between the proportion of afferent loop and efferent loop ulcer in patients with Billroth Ⅱ gastrectomy and the proportion of duodenal ulcer in patients with Billroth Ⅰ gastrectomy (P =0.619).The diameter of GSU of patients with BillrothⅠ((1.1±0.7)cm)was larger than that of ulcer of patients with BillrothⅡ((0.8±0.6)cm) and the difference was statistically significant (t = 3.591 ,P = 0.007 ).The incidence of intestinal metaplasia and atypic hyperplasia of GSU was 8.1 % (22/272),and there was no significant difference in gastric ulcer,stoma ulcer,nek ulcer,afferent loop and efferent loop ulcer (all P >0.05).The incidence of gastric stump cancer of GSU was 4.0% (11/272)and that of gastric ulcer,stoma ulcer,nek ulcer,afferent loop and efferent loop ulcer was 13.2% (5/38 ),2.4% (4/169 ),1.8% (1/55 )and 1/10,respectively.The incidence of gastric stump cancer of gastric ulcer was significantly higher than that of stoma ulcer and nek ulcer, the differences were statistically significant (OR =6.250 and 8.182,95%CI :1.593 to 24.519 and 0.915 to 73.126,χ2 =8.687 and 4.788,P =0.012 and 0.040).There was no statistically significant difference in the incidence of gastric stump cancer of GSU in other gastric parts (all P > 0.05 ).There was no statistically significant difference in the incidence of intestinal metaplasia,atypic hyperplasia and gastric stump cancer between case with BillrothⅠgastrectomy and case with Billroth Ⅱ gastrectomy (P =0.650 and 0.733).Among the 11 gastric stump cancers,the number of cases with the onset time with 20 years,20-30 years and beyond 30 years after gastrectomy were one,three,seven,respectively.Conclusion The incidence of intestinal metaplasia, atypic hyperplasia and gastric stump cancer of patients with GSU was high,and the predilection site of GSU was the remnant stomach.

Resection of gastric stump cancer using da vinci robotic surgical system / 中华消化外科杂志

Although the surgical procedure and approach of da Vinci robotic surgical system-assisted radical resection of gastric cancer are gradually mature,it is rarely used for the resection of gastric stump cancer because of the complexity and low resection rate.In November of 2012,resection of gastric stump cancer using da Vinci robotic surgical system was performed in the Southwest Hospital.The short-term efficacy was satisfactory after the follow-up for 12 months.Da vinci robotic surgical system has the advantages of clear vision,easy manipulation of abdominal adhesion detaching,flexible operation and stable traction during resection of gastric stump cancer.

Clinical analysis of 76 cases of gastric stump cancer after subtotal gastrectomy / 上海第二医科大学学报

Objective To observe the treatment and outcomes of gastric stump cancer(GSC) after subtotal gastrectomy,and to analyse the possible related factors for the development of GSC. Methods The clinical data of 693 patients with subtotal gastrectomy were retrospectively analysed.The development,treatment and outcomes of GSC were observed,and the possible factors associated with the development of GSC were analysed. Results Seventy-six cases of GSC emerged in the 693 patients with subtotal gastrectomy.Fifty-one of the 76 cases were perfomed radical operations(n=36) or palliative resection(n=15).No death was found during the perioperative period,and the median survival time was 32.7 and 14.2 months,respectively.Those 25 without surgical management died 3 to 11 months after the development of GSC.Among the 76 cases with GSC,stomach was found as the original site of ulcer in 59(22.3%,59/259),and duodenal bulb in the other 17(3.9%,17/434)(P

Clinical Analysis of the Gastric Stump Cancer-Classification Proposed by the Korean Gastric Cancer Association-

PURPOSE: The aim of this study is to evaluate the clinicopathological features and treatment results of 49 cases of gastric stump cancer based on the classification proposed by the Korean Gastric Cancer Association. METHODS: A total of 49 patients with gastric stump cancer, who underwent operation from 1991 to 2000, were divided into three group: primary cancer (group I, n=20), remnant cancer (group II, n=15) and recurrent cancer (group III, n=14). The clinicopathological features and patient survivors in each groups were analyzed and compared with the primary upper one third cancer patients. RESULTS: The incidence of operated stump cancer was 0.8% (49/6, 445 cases) during the ten years. The male to female ratio was 3.9: 1 and mean age was 56.5 years (range 39~ 83 years). The resectability was 96% (47/49 cases) and curability was 73.4% (36/49 cases). There were 16 (80%), 1 (7%), 0 (0%) cases of benign primary disease and 4 (20%), 14 (93%), 14 (100%) cases of malignant primary disease in each group, respectively. The mean duration from primary disease to stump cancer was 21.7 years (10~40 years) in group I, 3.4 years (4 months~9 years 2 months) in group II and 3.4 years (1 year~7 years 5 months) in group III. The 5 year-survival rate was 45.1% in group I, 63.5% in group II and 0% in group III. But there was no statistic differences in 5 year-survival rates between stump cancer (33.0%) and primary cancer of the upper one third (30.9%). CONCLUSION: The condition of the primary disease, tumor location, duration of cancer development and tumor stage had statistical differences between the three groups. In the case of benign disease, the patients belonged in the high-risk group for the new development of gastric cancer following 20 years. Early detection of cancer in the remnant stomach by periodic follow up is important, especially in high-risk groups, and application of aggressive surgical treatment will improve patient survival.

Clinicopathological features of gastric remnant cancer / 中国普通外科杂志

Objective To study the clinicopathological features and treatment modality of patients with gastric remnant cancer after distal gastrectomy. Methods The data of 25 patients with gastric remnant cancer undergoing surgery during the recent 9 years were analyzed retrospectively.Results Patients with gastric remnant cancer showed a greater male predominance(5∶1). The mean interval between previous gastrectomy and diagnosis of gastric remnant cancer was 24.5 years,ranging from 12 to 35 years.The primary operation was Billroth Ⅱ reconstruction in 80% of the cases. R0 resection for gastric remnant cancer was performed in 14 cases,Palliative resection in 11 cases,and adjuvant chemotherapy in 18 cases. The 1-,3-and 5-year overall survival rate was 72.0%,56.0% and 36.0%,respectively,while the respective survival rate was 78.5%,71.4%,and 50.0% in radical surgery group,and 63.6%,36.3% and 18.1% in palliative surgery group(P

Gastric Stump Cancer

PURPOSE: Gastric stump cancer is defined as a cancer that develops in the stomach after a resection in cases of non-malignant or malignant gastric disease. The interval between the gastrectomy and the detection of gastric stump cancer must be over 5 years. Since duodenogastric reflux gastritis is a precancerous condition and one of the most important factors inducing gastric stump cancer, we compared the bile-acid content of gastric juice between gastric stump cancer patients and controls. MATENRIALS AND METHODS: To evaluate retrospectively the surgical treatment of patients with gastric stump cancer, we reviewed the cases histories of 1016 stomach cancer patients who had been operated on at the Department of General Surgery, Kosin University Gospel Hospital, between 1995 and 1998. The gastric juice was collected during the operations on the gastric stump cancer patients by using a needle puncture of the fundus of the stomach and during the endoscopic examinations of the control subjects. The samples were analyzed for various bile acids (gas chromatography/mass spectrometry). RESULTS: The 6 gastric stump cancer cases accounted for 0.6% of all gastric cancer patients; 5 patients were first operated on for a peptic ulcer and the remaining one for an adenocarcinoma of the stomach. All of the cases were men. The reconstruction method after the initial gastrectomy was a Billroth II in all cases. The sites of the gastric stump cancer were the anastomotic sitein 2 patients, the upper body in 2, the fundus in 1 and the cardia in 1. The operative methods were 3 total gastrectomies, 2 subtotal gastrectomies with Roux en Y anastomosis, and 1 partial gastrectomy with lymph node dissection and had a curative intention in all patients. All of the patients were still surviving at the time of this report. The gastric juices of 4 gastric stump patients showed significantly higher contents of cholic acid (36.42microgram/ ml) compared to the gastric juices of 35 control subjects (12.82microgram/ml)(p< or =0.0001). Chenodeoxycholic acid and lithocholic acid were not significantly different. CONCLUSION: The gastric juice of gastric stump cancer patients contained a significantly higher cholic acid content. At the time of the initial gastrectomy, an operative method that prevents duodenogastric reflux may prevent or minimize the development of gastric stump cancer, and more aggressive surgical treatment may improve survival.

Esophagus, Stomach & Intestine; One Case of Early Gastric Stump Cancer Following Partial Gastrectomy for Gastroptosis / 대한소화기내시경학회지

Gastric stump cancer is defined as cancers that develop in the gastric remnant after the gastric resection of nonmalignant lesions or malignant lesions. The interval between gastrectomy and the detection of gastric stump cancer must be over 5 years in nonmaligant lesions and 10 years in malignant lesions. Symptoms of gastric stump cancer are not specific, so, diagnosis is often delayed. Early detection and curative operation is very important in gasric stump cancer and follow-up endoscopic examination is the most importaint diagnostic tool to detect gastric stump cancer. Recently we experienced a case of early gastric stump cancer. We report review of the literature to remind the important of gastric stump cancer and the important of follow-up endoscopic examination.