ABSTRACT
Objective To explore the serum level of gentamycin for orally in children with serious illness.Methods The serum level of gentamycin in 41 children who were in serious illness [multiple organ dysfunction(MODS)group with 21 cases and non-MODS group with 20 cases ] were monitored and the patients were treated with select decontamination of the digestive tract(SDD) from October 2004 to April 2005.Dosage:10 mg/(kg?d),orally taken three times(every 8 hours) one day.The blood after taking the drug one hour later in the fourth day was selected and the serum level of getamycin was monitored.Results Thirty-six children of 41 cases serum level of gentamycin were negative and 5 children(4 in MODS group and 1 in non-MODS group) who had alimentary tract hemorrhage were masccline in serum after taking gentamycin one hour later in the forth day.The absorption of gentamycin from enteric after orally was not(rela)-ted to MODS.There were statistics value between the gestrintestinal tract ulcer and serum level of gentamycin.Conclusions The safety for treating the children in serious illness with gentamycin for SDD is obvious.But we suggest to monitor the serum level of gentamycin for who has severe alimentary tract hemorrhage together with insufficiency of liver and kindey.
ABSTRACT
Animal model of aged rat nephrotoxicity was induced by i. p. administrationof gentamycin in a dose of 140mg/kg/day. Part of those rats were treated with CordycepsSinensis(CS), Epimedium(Ep) and Astragalus Membranaccus (AM) in form of decoc-tion per Os and others seryed as control. The results were summarized as. 1. The nephro-toxicity of gentamycin was aggrevated with age. CS, Ep and AM are effective drugs inpreventing the tdeular damage caused by gentamycin in rats. The pathological changes ofrenal tuoules of the rat groups which treated with CS, Ep and AM were less severe thanthat of the control. 2. CS, Ep and AM could prevent the decline of renal cortical Na~+-K~+-ATPase activity of aged rat induced by gentamycin.
ABSTRACT
To develop a biodegradable implant with both the ossific and anti infectious abilities. Antigen extracted bovine cancellous bone combined with bBMP as the center carrier was coated with either gelatin or poly ? caprolaton (PCL). They were then compounded with gentamicin. Their in vivo gentamycin releasing characteristics were assayed. There was an initial phase of rapid release of gentamycin within 24 hours, followed by a second phase of sustained but gradual diminution of drug release. Effective release of gentamicin from the PCL encapsulated RBX G LDDS may last 30 days in vivo . There was no significant difference in releasing rate between 30% gelatin and 40% gelatin in statistic. The results showed that RBX gentamycin possessed a fine in vivo gradual release property. Collaborated with its ossification activity, it could be considered as an ideal repair material for open fracture with bone defect.