ABSTRACT
Pancreatic panniculitis is a rare condition, affecting 2 to 3% of patients with pancreatic diseases, such as acute pancreatitis or pancreatic carcinoma. The clinical manifestations of panniculitis are painful erythematous nodules, predominantly affecting the lower limbs. From an anatomopathological point of view, the subcutaneous nodules are made of fat necrosis and vacuolated macrophages. The treatment consists in resolving the underlying diseases. We present the case of a 56-year-old female, admitted on the Emergency Department, who presented with acute abdominal pain and subcutaneous erythematous nodules. The combination of laboratory data, clinical and anatomopathological results confirmed the pancreatic panniculitis, in an underlying acute pancreatitis. The treatment focused on the resolution of the pancreatic disease.
ABSTRACT
Ghost cell odontogenic carcinoma (GCOC) is a malignant odontogenic epithelial tumor which is an exceedingly rare, highly aggressive, rapidly growing, and infiltrative tumor forming the malignant counterpart of long-standing benign cystic lesions coming in the spectrum of calcifying odontogenic cysts. To date, only a few cases have been reported in the medical literature. A case of unusual presentation of GCOC is presented and the clinical, histopathological, and immunohistochemical features are discussed along with a literature review. Our case report further emphasizes the bizarre biological behavior of this tumor and the need for strict long-term surveillance of the patients as metastasis to distant sites has been reported.
ABSTRACT
BACKGROUND: Although histological diagnosis of pilomatricoma is not difficult because of its unique histological features, cytological diagnosis through fine-needle aspiration cytology (FNAC) is often problematic due to misdiagnoses as malignancy. METHODS: We reviewed the cytological features of 14 cases of histologically-proven pilomatricoma from Korea Cancer Center Hospital, with a discussion on the diagnostic pitfalls of FNAC. RESULTS: Among 14 cases of pilomatricoma, 10 (71.4%) were correctly diagnosed through FNAC, and two (14.3%) were misdiagnosed as carcinoma. Cytologically, all cases had easily recognizable clusters of basaloid cells and foreign body-type multinucleated cells. Although ghost cells were also found in all cases, some were inconspicuous and hardly recognizable due to their small numbers. CONCLUSIONS: An accurate diagnosis of pilomatricoma in FNAC is feasible with consideration of clinical information and close examination of ghost cells.
Subject(s)
Biopsy, Fine-Needle , Diagnosis , Diagnostic Errors , Korea , PilomatrixomaABSTRACT
Pilomatricoma is an uncommon, harmless, skin lesion derived from hair matrix cells. It is also spelled 'pilomatrixoma' and sometimes known as 'calcifing epithelioma of malherbe'. It is most often diagnosed in young children but may also affect adults. Single skin-coloured or purplish lesions arised on the head and neck, but they may occur on any site. They are characterized by calcification within the lesion, which makes it feel hard and bony. FNAC can help us in the diagnosis but excisional biopsy and histopathological examination is recommended for confirmation and curative treatment. We present a rare case of pilomatricoma of the digit in an adult female.
ABSTRACT
Calcifying cystic odontogenic tumor is an uncommon odontogenic neoplasm which is included in the heterogenous group of lesions under a broader description of Ghost cell odontogenic tumors. All these lesions have the presence of ghost cells as a common feature. Calcifying cystic odontogenic tumor is a unique lesion with variable biologic behaviour and found to occur with other odontogenic tumours. We present a case of Calcifying cystic odontogenic tumor occurring in a 15 year old boy involving an unerupted permanent canine and premolar. The tumor was multicystic in nature and was associated with a complex odontome. This article also includes an update on nomenclature and classification of ghost cell odontogenic lesions.
ABSTRACT
The purpose of this study is to know whether there are differences between hematology profile and morphology of erythrocytes of blood specimens which are prepared with excessive Na2EDTA anticoagulant in different concentration. This study was conducted in Faculty of Medicine Gadjah Mada University. The criteria of subject were male, age from 18 until 22 years old and healthy, ascertained from history taking and vital sign examination. Blood samples from 33 subjects were taken using vein puncture. Two millimeters blood was divided into 4 Na2EDTA-containing tubes. Before that, one drop of blood without Na2EDTA anticoagulant was used for making control blood film right after vein puncture. Each tubes contained different concentration of anticoagulant. The first tube contained Na2EDTA in standard concentration 2 mg/dl; the remaining tubes contained consecutively, 4 mg/dl, 6 mg/dl, and 8 mg/dl. Those samples were immediately examined using SYSMEX SE-9500 automatic analyzer for measuring erythrocytes hematological profile and were stained with Wright staining for morphological examination. These procedures were done before 20 minutes of vein puncture. There were significant decrease of RBC count, HGB, HCT, and MCHC and also significant increase of MCV and RDW between different concentrations of excessive Na2EDTA anticoagulant. MCH did not have significant result. Morphological examination showed significant morphological changes in the form of echinocytes and appearance of ghost cells in the sample treated with excessive Na2EDTA anticoagulant concentration. In conclusion, there are differences in hematological profile and morphology of erythrocytes among blood specimen which are prepared with excessive Na2EDTA anticoagulant in different concentration, except for MCH. Excessive Na2EDTA anticoagulant concentration will affect the blood specimen for peripheral blood examination of erythrocytes by interfering morphology and some of hematological parameters.