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Objective To investigate the predictive value of glycosylated serum protein (GSP) combined with glycemic variability (GV) in persistent inflammation immunosuppressive catabolic syndrome (PICS) in elderly septic patients. Methods A retrospective study was conducted. The septic patients aged≥60 years old with 28 days hospitalized duration admitted to geriatric intensive care unit (ICU) of Guangzhou General Hospital of Guangzhou Military Command from January 2014 to December 2017 were enrolled. The patients were divided into two groups according to whether PICS occurred within 14 days after ICU admission according to the PICS diagnostic criteria. General patients' data including gender, age, underlying disease, site of infection, the length of ICU stay were collected, acute physiology and chronic health evaluation Ⅱ (APACHE Ⅱ), GSP at 1 day after hospitalization and lymphocyte count (LYM), C-reactive protein (CRP), albumin (ALB), prealbumin (PA) levels at 1 day and 14 days were recorded. The levels of blood glucose on the 1st day and 14th day were observed, the GV was calculated. Data were cross-validated using the random forest method. Receiver operating characteristic (ROC) curve was plotted to evaluate the predictive value of glycemic parameters for PICS. Results A total of 315 elderly septic patients were included. Patients with malignant tumors, severe autoimmune diseases, and immunosuppressive therapy or dead within 28 days of hospitalization were excluded. A total of 132 patients were enrolled in the analysis, including 45 in the PICS group and 87 in the non-PICS group. The length of ICU stay in the PICS group was significantly longer than that in the non-PICS group [days: 35.0 (22.0, 49.5) vs. 8.0 (5.0, 23.0), P < 0.01]. No significant difference in the baseline data of gender, age, underlying disease, infection site or APACHE Ⅱ score between the two groups was found. ① Parameters for PICS diagnosis: with the prolongation of ICU stay, LYM and PA in the non-PICS group were increased and those in the PICS group were decreased, and CRP and ALB levels were decreased in both groups. LYM, ALB and PA levels in the PICS group were significantly lower than those in the non-PICS group at 14 days after ICU admission [LYM (×109/L): 0.6 (0.5, 0.7) vs. 1.1 (0.9, 1.6), ALB (g/L): 25.4±2.7 vs. 29.9±4.3, PA (g/L): 0.08 (0.05, 0.14) vs. 0.11 (0.10, 0.21), all P < 0.01], and CRP level was significantly higher than that in the non-PICS group (mg/L: 87.5±56.3 vs. 49.2±49.1, P < 0.01). ② Glycemic parameters: the GSP level of the PICS group at 1 day after ICU admission was significantly lower than that of the non-PICS group (mmol/L: 2.3±0.6 vs. 2.7±0.6, P < 0.01), but there was no statistically significant difference in the level of blood glucose or GV at 1 day and 14 days after ICU admission as compared with the non-PICS group [blood glucose (mmol/L): 10.0±3.3 vs. 9.4±3.3 at 1 day, 10.8±3.6 vs. 10.4±3.5 at 14 days; GV: (24.2±1.4)% vs. (23.7±1.2)% at 1 day, (24.8±7.8)% vs. (24.7±7.7)% at 14 days, all P > 0.05]. ③ ROC curve analysis: 1-day GSP as well as 1-day and 14-day GV had certain predictive value for PICS secondary to sepsis in the elderly. The predictive value of 1-day GSP combined with 14-day GV was the highest, its area under ROC curve (AUC) was 0.637, with a sensitivity of 95.8% and a specificity of 25.0%, while the positive likelihood ratio was 1.278, the negative likelihood ratio was 0.167, the positive predictive value was 71.9%, and the negative predictive value was 75.0%. Conclusion GSP combined with GV could effectively predict secondary PICS in elderly septic patients.
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Objective To investigate the clinical value of glycosylated hemoglobin(HbA1c),glycosylated serum protein(GSP),sex hormone binding globulin(SHBG),three acylglycerol(TG),free fatty acid(FFA)in diagnosing gestational diabetes mellitus(GDM).Methods 103 cases of GDM patients and 98 cases of healthy pregnant women from February 2015 to August 2016 were selected as the GDM group and control group.The positive detection rates and levels of HbA1c,GSP,SHBG,TG and FFA were compared between the two groups.Moreover the diagnostic efficiency of various indicators was analyzed.Results The levels of HbA1c, GSP,TG and FFA in the GDM group were significantly higher than those in the control group,while the SH-BG level was significantly lower than that in the control group,the difference was statistically significant(P<0.05);the positive rates of HbA1c,GSP,SHBG,TG and FFA in the GDM group were significantly higher than those in the control group,the difference was statistically significant(P<0.05);the specificity,sensitivity and positive prediction value of HbA1c,GSP,SHBG,TG and FFA for jointly diagnosing GDM were signifi-cantly higher than those of single indicator,the difference was statistically significant(P<0.05).Conclusion Detecting HbA1c,NGSP,SHBG,TG and FFA is more accurate for jointly diagnosing GDM,has an important diagnostic value,and can serve as the assisted diagnostic indicators.
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0.05). In comparison with the control group,the levels of FPG and GSP were significantly higher (P
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The concentration of glycosylated serum protein (GSP) in 125 normal subjects and 105 diabetic patients was measured. The result showed that the mean value of GSP in diabetic patients increased as compared with that of normal subjects, and the mean , concentration of GSP correlated significantly with that of fasting blood glucose in diabetic patients as well as that the mean value of fasting blood glucose which was determined 1-3 weeks before. The level of GSP may be a sensitive indicator for recent control of diabetes
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Objective To investigate the effect of chrysalis oil on blood glucose and oxidative stress in diabetic rats induced by Streptozotocin (STZ).Method Sixty male SD rats were divided into 6 groups according to blood glucose:normal group,diabetic control group,high,medium,low dose (7.5,6.0,4.5ml/kg bw.) chrysalis oil groups and positive control group.Food and fluid intake were monitored every day.blood glucose and body weight were measured at each weekend,and at the end of experiment,glycosylated serum protein (GSP) was tested,and the effect of chrysalis oil on the content of malondialdehyde (MDA),reduced glutathione (GSH),total antioxidant capacity (T-AOC) in liver and pancreas were observed.Results (1) Diabetic symptoms were ameliorated and blood glucose and GSP were all lowered in therapeutic groups compared with diabetic control group,whereas,high dose chrysalis oil group had the same effect as positive control group.(2) In diabetic groups treated with chrysalis oil,the activity of GSH and T-AOC were significantly increased and the content of MDA decreased compared with diabetic control group.Conclusion Chrysalis oil could decrease blood glucose in a dose-and-effect relationship and improve antioxidant capacity.