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Abstract Objective: To investigate the clinical implications of Golgi glycoprotein 73 (GP73) and granulocyte colony-stimulating factor (G-CSF) in children with bronchopneumonia (BP). Methods: Seventy-two children with BP (observation group) and 81 healthy children (control group) consecutively brought to the present study's hospital between June 2019 and October 2020 were enrolled. GP73 and G-CSF levels were determined to analyze their diagnostic value for pediatric BP. High-sensitivity C-reactive protein (hs-CRP) was also measured. The clinical implications of GP73 and G-CSF in pediatric BP complicated with respiratory failure and their connections with the inflammatory response were discussed. Results: GP73 and G-CSF levels were remarkably higher in the observation group (p< 0.05). The sensitivity and specificity of combined detection (GP73+G-CSF) in predicting pediatric BP were 72.22% and 86.42%, respectively (p < 0.001 ). GP73 and G-CSF, which are closely related to X-ray classification and complications in the observation group, decreased after treatment and were positively correlated with hs-CRP (p < 0.05), especially in children complicated with respiratory failure. Regression analysis identified the independence of the course of the disease, hs-CRP, X-ray classification, GP73, and G-CSF as influencing factors of respiratory failure in children with BP (p < 0.05). Conclusion: GP73 and G-CSF, with elevated levels in children with BP, are strongly linked to disease progression and are independent influencing factors of respiratory failure, which may be the key to diagnosing and treating pediatric BP in the future.
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Objective To evaluate the diagnostic value of three tumor markers ,including alpha‐fetoprotein(AFP) ,golgi glyco‐protein 73(GP73)and tumor specific growth factor(TSGF) ,and significance of combined detection in diagnosis of primary liver cancer(PHC) .Methods Serum levels of AFP ,GP73 and TSGF were detected in 90 cases of patients with PHC(PHC group) ,52 cases of patients with liver metastasis(liver metastasis group) ,41 cases of patients with benign liver disease(benign liver disease group) ,and 55 cases of healthy individuals(healthy control group) .And clinical value of combined detection of AFP ,GP73 and TS‐GF for diagnosing PHC was analysed .Results The serum levels of AFP ,GP73 and TSGF were significantly higher than those in benign liver disease group and healthy control group ,the differences were statistically significant(P< 0 .05) .The specificity of AFP ,GP73 and TSGF in diagnosis of PHC was 79 .7% ,71 .6% and 83 .1% ,respectively .The sensitivity of AFP ,GP73 and TSGF in the diagnosis of PHC was 57 .8% ,74 .4% and 65 .6% ,respectively .The combined detection of AFP ,GP73 and TSGF improved the sensitivity for diagnosing PHC(96 .6% ) ,while the specificity of combined detection was decreased(68 .9% ) .And the diagnosis rates of PHC patients with negative AFP or low levels of AFP were increased when combined the three tumor markers . Conclusion Combined detection of AFP ,GP73 and TSGF as a significant indicator for diagnosing PHC could improve the diagnosis rate of PHC .
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it was 4% (3/75). GP73-positive rate in HCC was higher than that of the normal liver tissues (χ2=73.60, P0.05). GP73 was associated with survival but not sCLU. Conclusion:GP73 and sCLU have higher positive rates in HCC and GP73 is positively correlated with sCLU. The expression of GP73 and sCLU are probably closely related with the invasion of HCC, which can help evaluate the prognosis of the patients.