ABSTRACT
Objective To design and develop a multi-modality medical image fusion and evaluation simulation system to eliminate the deficiencies of the images by different technologies.Methods The system was developed with MATLAB 2014a development platform as well as MATLAB graphical user interface and image processing toolbox.Results Common methods were realized of multi-modality medical images,and the evaluation on seven objective indicators was implemented such as entropy,mutual information,cross entropy,mean,standard deviation and etc.Conclusion The system behaves well in interactivity,practicality and extensibility,and is of great significance for clinical diagnosis as well as teaching medical image processing in specialties of biomedical engineering,medical image technology and etc.[Chinese Medical Equipment
ABSTRACT
Objective To design and develop a multi-modality medical image fusion and evaluation simulation system to eliminate the deficiencies of the images by different technologies.Methods The system was developed with MATLAB 2014a development platform as well as MATLAB graphical user interface and image processing toolbox.Results Common methods were realized of multi-modality medical images,and the evaluation on seven objective indicators was implemented such as entropy,mutual information,cross entropy,mean,standard deviation and etc.Conclusion The system behaves well in interactivity,practicality and extensibility,and is of great significance for clinical diagnosis as well as teaching medical image processing in specialties of biomedical engineering,medical image technology and etc.[Chinese Medical Equipment
ABSTRACT
La queratotomía radial es uno de los métodos quirúrgicos empleados para corregir los defectos ópticos de las personas; ésta ha sido ampliamente estudiada, e incluso se han propuesto nomogramas que permiten predecir los resultados de algunas geometrías; a pesar de esto, las experiencias postoperatorias han demostrado que la tasa de éxito de las cirugías es baja, ya que se presenta hipocorrección o hipercorrección de los pacientes, obligándolos a usar ayudas externas o llevándolos a someterse nuevamente a una cirugía. Teniendo en cuenta esto, se desarrolló una plataforma para simular estas cirugías por medio del método de elementos finitos, empleando los programas Matlab y COMSOL Multiphysics. Por medio de la rutina creada es posible obtener un modelo de la córnea preoperatoria que se asemeje tanto en geometría, como en condiciones de esfuerzo, a la córnea real; adicionalmente, es posible adaptar la geometría de la queratotomía radial que desee simularse. Se realizaron simulaciones para una cirugía compuesta de dos arcos y otra de tres arcos; los resultados obtenidos demuestran la capacidad de la simulación numérica para avanzar en el desarrollo de la cirugía refractiva, al ser posible estudiar parámetros, que de forma experimental, son difíciles de tener en cuenta, como la geometría inicial de la córnea y la edad del paciente, lo cual influye en el módulo de elasticidad del material; por otra parte, se encontró que esta aplicación es una potencial herramienta para los oftalmólogos, pues tiene la capacidad de predecir los resultados postoperatorios.
Radial keratotomy is used as a methodology to correct refractive errors. This surgery has been widely studied and also nomograms have been proposed in order to predict postoperative results of some types of keratotomies. Despite these eff orts, surgical evidence has shown a low success rate because of undercorrection or overcorrection, forcing patients to use spectacles or contact lenses, after surgery, or even leads them to a new procedure. A simulation platform was developed in an attempt to study these surgeries, employing the finite element method, using Matlab and COMSOL Multiphysics simultaneously. The routine is capable of simulate the preoperative cornea in terms of geometry and stress configuration. Also, it could be adapted to simulate any kind of radial keratotomy LASIK and PRK surgeries. Simulations for a double arc keratotomy and a triple arc keratotomy were developed. Results provide evidence of the capability of the platform to improve knowledge of refractive surgery taking into account the possibility to analyze the effect produced by corneal geometry and patient age, which aff ects the elastic modulus of the material, parameters difficult to analyze in an in-vivo experiment. Besides, it demonstrates the potential of the program as a tool for the surgeon to plan refractive surgery.
Subject(s)
Keratotomy, Radial/statistics & numerical data , Corneal Surgery, Laser/trends , Cornea/surgery , Ophthalmologic Surgical Procedures/methodsABSTRACT
CpG is the pair of nucleotides C and G, appearing successively, in this order, along one DNA strand. It is known that due to biochemical considerations CpG is relatively rare in most DNA sequences. However, in particular subsequences, which are a few hundred to a few thousand nucleotides long, the couple CpG is more frequent. These subsequences, called CpG islands, are known to appear in biologically more significant parts of the genome. The ability to identify CpG islands along a chromosome will therefore help us spot its more significant regions of interest, such as the promoters or 'start' regions of many genes. In this respect, I developed the CpG islands search tool, CpG Islands Detector, which was implemented in JAVA to be run on any platform. The window-based graphical user interface of CpG Islands Detector may facilitate the end user to employ this tool to pinpoint CpG islands in a genomic DNA sequence. In addition, this tool can be used to highlight potential genes in genomic sequences since CpG islands are very often found in the 5' regions of vertebrate genes.