Gut-origin sepsis / 中国小儿急救医学

Gut-origin sepsis is paid more attention recently.Gut has become an important origin of sepsis for its full of bacteria and toxin and the role in immune regulation,which is hidden in infants and young children.We rarely diagnose gut-origin sepsis deliberately in clinic,but just as a source of infection.In this article,we discussed the pathogenesis including some debated problems and progress of treatment by literature review,hope to help clinicians improve the ability to diagnose and treat gut-origin sepsis.

Progress of research in neonatal sepsis from necrotizing enterocolitis / 临床儿科杂志

Necrotizing enterocolitis (NEC) is one of the severe gastrointestinal emergencies with high mortality in neo-natal period. Studies suggested that sepsis from NEC were associated with higher mortality in NEC. Therefore, it is important to explore the related factors and prevention measures of NEC and improve the prognosis of children with NEC. In recent years, studies have shown that the risk factors of sepsis in NEC included prematurity, low birth weight, long time of total parenteral nutrition supports and long duration of antibiotic exposure. The main pathogen of sepsis was gram-negative bacilli. Probiotics, glutamine and lactoferrin supplementation may reduce the incidence and severity of NEC, and may help further reduce the risk of gut-derived sepsis.