ABSTRACT
Objectives: This work was aimed at investigating, by means of ultrasonography, the impact of cardiovascular parameters on the physical endurance of runners participating in high altitude race. Experimental Design: This was a cross-sectional study. Place and Duration of the Study: The study was carried out in Cameroon. Anthropometric and cardiovascular parameters were recorded at the Regional Hospital annex of Buea (Cameroon) on the 12th and 13th February while race times were recorded at Molyko Stadium of Buea, on the 15th February 2014. Methodology: Out of 241 runners who finished the senior Mount Cameroon Race of Hope, 69 who were at least at their second participation, had voluntarily participated in the study. Haemodynamic parameters were collected through 2D transthoracic ultrasonography. Mann-Withney or Kruskal-Wallis tests and linear regression were used for statistical analysis. The significance level was set at p-value<0.05. Results: The mean LVEDD, LVDV, LVSV, LVMMI, SF/EF and TAPSE were 2.7±0.3 cm/m2, 88.5±49.3 mL/m2, 53.4±30.7 mL/m2, 131.1±28.6 g/m2, 69.3±9.4% and 1.7±0.3 cm/m2 respectively. In males and females, LVDV (mL/m2) was 98.6±55.3 vs. 64.2±12.6 (p=0.011) while LVSV (mL/m2) was 61.6±33.2 vs. 33.9±6.2 (p=0.0004), respectively. The linear regression model revealed that the lower the altitude, the greater the race time i.e. the weaker the performance (p=0.005; r2=0.12). In addition increase of LVDV related with increase of residential (p=0.025; r2=0.12) and training (p=0.021; r2=0.13) altitudes. Conclusion: Optimal values of haemodynamic parameters and/or high training altitude could be boosters of performance in endurance race at high altitude.
ABSTRACT
Objective To investigate the effects of 3％ and 7.5％ hypertonic saline (HS) on hemorrhagic shock patients in Emergency Department.Methods From December 2008 to February 2012,patients older than 15 years with severe trauma and systolic blood pressure (SBP) ≤70 mmHg or 70 to 90 mmHg with heart rate≥ 108 per minute were divided into three groups randomly (random number).Group A:patients treated with 3％ hypertonic saline (HS) 300 mL + lactated Ringer' s solutions (LRS).Group B:patients treated with 7.5％ HS 300 mL + LRS.Group C:patients treated with LRS.The mean arterial pressure (MAP),blood pressure (BP),heart rate (HR) were recorded before infusion and at 10,30,45,60 minutes successively after infusion.Incidence of complications and mortality rates were compared between groups.Results Atotal of 148 patients were enrolled in this study.Compared with LRS grouop,MAP was restored more promptly and maintained persistently in 3％ HS group and 7.5％ HS group,and the total volume of fluid infused was decreased to almost 50％ of LRS in the first 1 hour.No significant differences in MAP levels were observed between group A and B except 30 minutes after infusion.Single bolus of 7.5％ HS infusion resulted in increased of HR to mean 127 beats per minute at 10 minutesafter fluid resuscitation.Higher incidence of arrhythmia and transient hypotension occurred in 7.5％ HS group.There were no statistical differences of changes of electrolytic indices,mortality rates,incidences of ARDS and MODS among three groups.Conclusions Resuscitation with 3％ HS provide similar benefits and lower risk of complications compared with 7.5％ HS and LRS.This study demonstrates the practicability and safety of 3％ HS for fluid resuscitation of patients with hypovolemic shock.