1.
Journal of Pharmaceutical Practice
;
(6): 241-245,265, 2014.
Article
in Chinese
| WPRIM
| ID: wpr-790326
ABSTRACT
Albumin is an ideal drug carrier , but its application was limited because of the shortcomings of short half -life and susceptible to enzymatic degradation in vivo .However, according to its structural features , albumin has a plurality of modification sites, which can be modified by PEG modifier to extend the cycle time and obstruct the action of the enzyme .Currently, the PEG-mod-ified albumin is still in the research stage , and there have been many studies about PEG-modified albumin , such as the role of PEG modification , the effects on albumin and its preparations and the modification sites selection .The article reviewed the related studies a-bout the PEGylation of albumin .