Abnormal status of tumor markers detected among healthy physical examinees: clinical significance of early tumor screening at molecular level / 临床与实验病理学杂志

Purpose The aim of this study is to define molecular sub-healthy status among individuals attending routine physical examination.Methods This study examined 8 blood tumor markers among 5 825 healthy individuals.Results (1) Differences in levels of tumor markers were observed between males and females.(2) Elevated CA72-4 levels were seen in 16.05％ of individuals in both sexes.(3) More males had elevated levels of CEA and CYFRA21-1.Among the individuals with elevated levels of tumor markers,most were clustered in the prime age group of 41 to 50 years.Conclusion This is the first large-sample survey in healthy Han population in Xinjiang,which found elevated levels of all 8 markers tested with varying rates.Accordingly,this study proposes for the first time a concept of molecular sub-healthy status and a strategy of early tumor screening at molecular level.The molecular sub-healthy status may be an early warning sign for potential cancers,which should draw attention by preventive public health policies.

Analysis of pre-pregnancy laboratory examination results of 16 626 cases / 国际检验医学杂志

Objective To investigate healthy status and disease distribution of couples through analysing the results of pre‐preg‐nancy laboratory examination and to explore high risk factors ,in order to provide scientific references for the realization of eugenics . Methods The routine blood test ,serum markers of hepatitis B ,five items(TORCH) examination ,detection of female vaginal secre‐tions were carried out in 8 313 couples planning pregnancy from 2013 to 2014 ,and the results of pre‐pregnancy health examination were analysed and evaluated .Results The thyroid dysfunction accounted for 17 .43% of all women undergoing examination ,which was the most common disease .Among items carried out in all couples ,thalassemia and positive of hepatitis B surface antigen were the most common ,accounted for 10 .20% and 9 .94% respectively .Conclusion The pre‐pregnancy health examination could screen high risk factors ,which is benefit for guiding eugenics and effectively reducing the birth defects and adverse pregnancy and is a sig‐nificant measure for eugenics .

The healthy status of workers at Chem Concrete Manufacture, Hanoi

A retrospective surveyed was conducted on the plant of concrete with 127 workers. The secondary data about the health, the clinical and paraclinical diagnosis realized on all workers. Analysis showed that the second grade of health accounted for 40.94%, 3rd grade 49.62%, none of 1st grade and 4th grade 1.57%. A diversity of morbid included ENT diseases, maxial-odonto-facial diseases, gynecological diseases, ophtalmological disease, gastrointestinal diseases, muscle-bone-joint diseases, venerological, mental-neurological, respiratory, urological, cardiovascular diseases. 2 cases of occupational pneumocomosis were detected.